Development of an anti-CD45RA-quantum dots conjugated scFv to detect leukemic cancer stem cells

Moradi‐Kalbolandi, Shima; Dashtestani, Fariba; Salehi, Mina; Jalili, Neda; Majidzadeh‐A, Keivan; Rahighi, Reza; Yadegari, Amir; Farahmand, Leila

doi:10.1007/s11033-019-05122-w

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…So anti-CD45RAÀ C dot conjugated scFv may be a suitable and sensitive biosensor for the detection of LSCs. [136] Alkaline phosphatase (ALP) is recognized as a stem cell marker and quantitative detection of the ALP levels is a promising approach for the detection of cancer stem cells. Fan et al used cauliflower-derived carbon dots (CFCDs), as an ALP activator.…”

Section: Drug Delivery Ability and Detecting Capacity Of Cqds In Canc...mentioning

confidence: 99%

“…The results of an Immunostaining analysis under fluorescence microscopy have shown that the anti‐CD45RA−C dot conjugated scFv attached to the CD45RA+ Jurkat cell lines but not to the CD45RA– K562 cell lines. So anti‐CD45RA−C dot conjugated scFv may be a suitable and sensitive biosensor for the detection of LSCs [136] …”

Section: Drug Delivery Ability and Detecting Capacity Of Cqds In Canc...mentioning

confidence: 99%

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Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Juybari

Faramarz

Sadeghi³

et al. 2023

Chemistry & Biodiversity

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Some issues, such as their obscure fate or low survival rate into the body during stem cell therapy, should be addressed to boost efficiency. Nanotechnology offers a suitable solution to combat such limitations. Carbon quantum dots (CQDs) are carbon-based nanomaterials and may be used as multi-purpose compounds in stem cell therapy. CQDs are excellent choices for stem cell labeling thanks to their special features such as optical properties and good biocompatibility. Besides, they can modulate the biological function of stem cells, such as their proliferation, homing ability, and differentiation properties. Considering the charismatic feature of CQDs and their broad unique effect on stem cells, the current review aims to summarize the advancements in this field. Hence, we first focused on CQDs synthesis and their applications. In the next section, the stem cell categories will be discussed, and the final part is dedicated to the recent research evaluating the impact of CQDs on stem cell therapy.

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Section: Drug Delivery Ability and Detecting Capacity Of Cqds In Canc...mentioning

confidence: 99%

Section: Drug Delivery Ability and Detecting Capacity Of Cqds In Canc...mentioning

confidence: 99%

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Juybari

Faramarz

Sadeghi³

et al. 2023

Chemistry & Biodiversity

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show abstract

“…[19][20][21][22][23] Some signal amplification strategies based on RCA have been applied to achieve sensitive detection of markers at low levels. [24][25][26][27] Proteins are the key markers of disease, [28][29][30][31] therefore the development of highly sensitive methods to detect protein markers is a promising direction for disease. This paper reviews protein detection based on RCA using for example fluorescence [32] and electrochemistry.…”

Section: Introductionmentioning

confidence: 99%

Protein detection based on rolling circle amplification sensors

Shi

Cui

Sulemana³

et al. 2021

Luminescence

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Rolling circle amplification (RCA) is an isothermal process under the action of DNA polymerases. Large-scale DNA templates have been generated using RCA for target detection. Some signal amplification strategies including optical sensors and electrochemical sensors based on RCA have been applied to achieve sensitive detection.Sensors based on RCA have attracted increasing interest. Advances in RCA-based sensors for protein detection are reviewed in this paper. The advantages and detection mechanisms of sensors based on RCA are revealed and discussed. Finally, possible challenges and future perspectives are also outlined.

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Quantum dots as nano drug delivery system

Patel,

Jain

2024

Progress and Prospect of Nanocarriers

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Development of an anti-CD45RA-quantum dots conjugated scFv to detect leukemic cancer stem cells

Cited by 7 publications

References 21 publications

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Protein detection based on rolling circle amplification sensors

Quantum dots as nano drug delivery system

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