Development of an Apparatus to Measure Plasma Colloid Osmotic Pressure Mounted on the Extracorporeal Hemodialysis Circuit.

Abe, Ryoetsu; Ooishi, Shigemi; Sato, Kazuto; Suma, Hiroshi; Wakabayashi, Tsunemichi; Sawatani, Satoshi; Takeuchi, Hiroyuki

doi:10.1620/tjem.176.149

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…In the current study, the average of the measured COP was 22.0 ± 0.2 mm Hg, indicating COP values in HD patients are relatively low compared to those of healthy controls. In particular, the measured COP just before HD further decreased to 20.0 ± 0.2 mm Hg, consistent with a previous report . In regards to serum albumin, a decrease in its concentrations has been often observed in HD patients.…”

Section: Discussionsupporting

confidence: 91%

“…To develop an approximation formula based on measured COP values, we performed a stepwise analysis using serum albumin and non‐albumin proteins (calculated by the difference between the total protein concentration and the serum albumin concentration). Afterwards, we obtained the following simple formula for COP approximation:

\begin{matrix} left \\ Formula 5 COP (mm Hg) \\ = - 7.91 + 5.64 \times albumin (normalg / dL) + 3.00 \\ \times non-albumin proteins (normalg / dL) \end{matrix}

…”

Section: Resultsmentioning

confidence: 99%

“…Plasma COP values are essential for calculating markers of vascular permeability, such as Kr values. However, only a few studies have reported on the direct measurement of COP in HD patients , and the relationship between measured and predicted COP using previously published formulas remains unclear . Of importance, these previously reported formulas for COP prediction are not based on HD patients and therefore may not be suitable for these patients .…”

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confidence: 99%

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Method for Approximating Colloid Osmotic Pressure in Long‐Term Hemodialysis Patients

et al. 2013

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Colloid osmotic pressure (COP) is important in calculating vascular permeability during hemodialysis (HD). However, few reports have directly measured COP in HD patients. Therefore, the currently published formulas may not be clinically optimal for predicting COP for HD patients. Here, the study aims were (i) to directly measure COP in HD patients and compare the measured and predicted COP values using four previously reported formulas, and (ii) to develop a formula for approximating COP using clinical parameters. We obtained 212 measured COP values using an osmometer; the average value was 22.0 ± 0.2 mm Hg. The predicted COP based on the four different formulas was positively correlated with the measured COP (0.87 < r < 0.89), but was significantly overestimated compared to it (P < 0.001). We also performed a stepwise analysis using serum albumin and non-albumin protein concentrations and obtained the following simple formula for COP approximation: COP (mm Hg) = -7.91 + 5.64 × albumin (g/dL) + 3.00 × non-albumin proteins (g/dL). A positive linear correlation was observed between the measured COP and approximated COP using this formula (r = 0.90, P < 0.001). We calculated the mean Kr (plasma-refilling coefficient) as a marker for determining dry weight in HD patients using the measured COP and approximated COP. No differences were observed between the mean Kr derived from the measured and approximated COP. We report here significant differences between measured and predicted COP values, and have devised a simple formula for COP approximation in HD patients.

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Section: Discussionsupporting

confidence: 91%

\begin{matrix} left \\ Formula 5 COP (mm Hg) \\ = - 7.91 + 5.64 \times albumin (normalg / dL) + 3.00 \\ \times non-albumin proteins (normalg / dL) \end{matrix}

…”

Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Method for Approximating Colloid Osmotic Pressure in Long‐Term Hemodialysis Patients

et al. 2013

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“…A continuous measurement of plasma COP using a dialyzer has been presented many years ago . In this previous application the filter was placed in a secondary circuit perfused by a separate pump and TMP h was measured by a difference‐pressure sensor.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Colloid Osmotic Pressure on Hydrostatic Pressures in High‐ and Low‐Flux Hemodialyzers

et al. 2018

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The aim of this study was to examine the relationship between hydrostatic trans-membrane pressure (TMP ) and colloid osmotic pressure (COP) in low-flux (LF) and high-flux (HF) dialyzers. Hydrostatic pressures were measured in dialyzers distinguished by their ultrafiltration coefficient K (16 and 85 mL/h/mm Hg) under constant dialysate flow and variable blood flow (Q ) ranging from 0 to 400 mL/min using (i) alginate (70 kDa) dissolved in dialysate, (ii) diluted, undiluted, and concentrated plasma, or (iii) whole blood at different hematocrit, all in absence of ultrafiltration (UF). For a given fluid, TMP linearly increased with increasing Q . The intercept of the linear TMP to Q relationship correlated with measured COP with an average bias of 1.00 ± 2.26 mm Hg and a concordance correlation coefficient of 0.98. The slope of the linear TMP to Q relationship increased with increasing sample viscosity and was much larger in HF dialyzers under otherwise identical operating conditions, most likely because of increased internal filtration. The TMP to Q relationship measured in dialyzers in absence of UF can be described by the intercept related to measured COP and the slope related to internal filtration. This relationship could be of interest to estimate internal filtration and COP under in vivo conditions.

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Development of an Apparatus to Measure Plasma Colloid Osmotic Pressure Mounted on the Extracorporeal Hemodialysis Circuit.

Cited by 2 publications

References 6 publications

Method for Approximating Colloid Osmotic Pressure in Long‐Term Hemodialysis Patients

Method for Approximating Colloid Osmotic Pressure in Long‐Term Hemodialysis Patients

The Influence of Colloid Osmotic Pressure on Hydrostatic Pressures in High‐ and Low‐Flux Hemodialyzers

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