Development of an Artificial Intelligence Tool for Detection of Polypoid Lesions in Inflammatory Bowel Disease (Ibd-Cade)

Vinsard, Daniela Guerrero; Fetzer, Jeffrey; Raffals, Laura H.; Agrawal, Upasana; Singh, Jasveer; Patel, Manishkumar; Avvaru, Himaja Kumari; Kaur, Manmeet P.; Lahori, Simmy; Sampath, Shrikanth; Arunachalam, Shivaram P.; Leggett, Cadman L.; Sundaram, Divaakar Siva Baala; Coelho–Prabhu, Nayantara

doi:10.1016/j.gie.2022.04.569

Cited by 4 publications

(3 citation statements)

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“…Similar systems are being developed also to detect colitis-associated dysplasia and will likely be available in the coming years, further improving surveillance. 67…”

Section: Methodsmentioning

confidence: 99%

“…Similar systems are being developed also to detect colitis-associated dysplasia and will likely be available in the coming years, further improving surveillance. 67 Furthermore, pioneering works are linking changes in the intestinal microbiota to specific diseases and in particular CRC. 68 Presence of certain bacterial species has been consistently associated with CRC and CRC in IBD.…”

Section: Future Perspectivesmentioning

confidence: 99%

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Image-Enhanced Endoscopy Surveillance of Colon and Pouch Dysplasia in IBD

Parigi

Nardone

Iacucci

2022

Diseases of the Colon &Amp; Rectum

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BACKGROUND: Patients with longstanding ulcerative colitis and Crohn’s colitis are at risk for developing colorectal cancer and need regular endoscopic surveillance to detect and remove precursor lesions. To do so, different technologies are available. DATA SOURCES: The sources are observational and controlled studies, meta-analysis, and expert consensus articles available on PubMed. STUDY SELECTION: The selected materials include articles reporting outcomes of and recommendations on endoscopic surveillance and resection of dysplasia in the gastrointestinal tract, including the ileoanal pouch and the anal transition zone, in patients with inflammatory bowel disease. MAIN OUTCOME MEASURES: Incidence and detection rate of dysplasia and cancer with different endoscopic techniques in patients with inflammatory bowel disease. RESULTS: Risk of cancer is proportional to the duration and extent of the disease, and surveillance interval should be tailored on the individual risk in a range of 1 to 5 years. High-definition imaging and virtual chromoendoscopy have improved the detection of dysplasia and are now comparable with conventional dye spray chromoendoscopy. After restorative proctocolectomy with ileoanal pouch, the risk of cancer is modest, but its high mortality warrants endoscopic surveillance. The evidence to guide pouch surveillance is limited, and recently, the first expert consensus provided a framework of recommendations, which include an initial assessment 1 year after surgery and follow-up depending on individual risk factors. LIMITATIONS: The limitation includes scarcity of data on ileoanal pouch surveillance. CONCLUSIONS: Virtual chromoendoscopy and high-definition imaging have improved endoscopic surveillance, and more progress is expected with the implementation of artificial intelligence systems.

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“…Similar systems are being developed also to detect colitis-associated dysplasia and will likely be available in the coming years, further improving surveillance. 67…”

Section: Methodsmentioning

confidence: 99%

Section: Future Perspectivesmentioning

confidence: 99%

Image-Enhanced Endoscopy Surveillance of Colon and Pouch Dysplasia in IBD

Parigi

Nardone

Iacucci

2022

Diseases of the Colon &Amp; Rectum

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“…In conclusion, the development of new advanced techniques promises to revolutionize IBD endoscopy and histology by improving disease characterization and, ultimately, patient care. Moreover, in addition to the histological assessment of IBD, the early detection of dysplasia is one of the major challenges in IBD endoscopy, and an AI system would be of great help in detecting precursor dysplastic lesions or early colorectal cancer [69].…”

Section: New Endoscopic Toolsmentioning

confidence: 99%

Evaluation of Disease Activity in Inflammatory Bowel Disease: Diagnostic Tools in the Assessment of Histological Healing

Jucan,

Gavrilescu,

Dranga

et al. 2023

Biomedicines

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Inflammatory bowel disease (IBD) comprises two types of chronic intestinal disorders: Crohn’s disease and ulcerative colitis. In long-standing ulcerative colitis disease activity, histological persistent inflammation has been linked to an increased risk of relapse, and long-term corticosteroid use, even when endoscopic remission is reached. In Crohn’s disease, the discontinuous nature of lesions and transmural inflammation have limited the standardized histological assessment. The current evidence from research proposes that besides clinical and endoscopic healing, the achievement of histological healing constitutes an endpoint to assess disease activity and remission in IBD patients concerning better long-term disease outcomes. Histological alterations may persist even in the absence of endoscopic lesions. For these reasons, new advanced techniques promise to revolutionize the field of IBD by improving the endoscopic and histologic assessment, disease characterization, and ultimately patient care, with an established role in daily practice for objective assessment of lesions. This review outlines the importance of including microscopic evaluation in IBD, highlighting the clinical benefits of a deep state of disease remission using validated diagnostic methods and scoring systems for daily clinical practice.

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Technological advances in inflammatory bowel disease endoscopy and histology

et al. 2022

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Accurate disease characterization is the pillar of modern treatment of inflammatory bowel disease (IBD) and endoscopy is the mainstay of disease assessment and colorectal cancer surveillance. Recent technological progress has enhanced and expanded the use of endoscopy in IBD. In particular, numerous artificial intelligence (AI)-powered systems have shown to support human endoscopists' evaluations, improving accuracy and consistency while saving time. Moreover, advanced optical technologies such as endocytoscopy (EC), allowing high magnification in vivo, can bridge endoscopy with histology. Furthermore, molecular imaging, through probe based confocal laser endomicroscopy allows the real-time detection of specific biomarkers on gastrointestinal surface, and could be used to predict therapeutic response, paving the way to precision medicine. In parallel, as the applications of AI spread, computers are positioned to resolve some of the limitations of human histopathology evaluation, such as interobserver variability and inconsistencies in assessment. The aim of this review is to summarize the most promising advances in endoscopic and histologic assessment of IBD.

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Development of an Artificial Intelligence Tool for Detection of Polypoid Lesions in Inflammatory Bowel Disease (Ibd-Cade)

Cited by 4 publications

References 0 publications

Image-Enhanced Endoscopy Surveillance of Colon and Pouch Dysplasia in IBD

Image-Enhanced Endoscopy Surveillance of Colon and Pouch Dysplasia in IBD

Evaluation of Disease Activity in Inflammatory Bowel Disease: Diagnostic Tools in the Assessment of Histological Healing

Technological advances in inflammatory bowel disease endoscopy and histology

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