Development of an autofluorescent probe for brain cancer: simulations and phantom studies

Leh, B.; Charon, Y.; Duval, M.; Jean, F; Lefèbvre, F.; Ménard, Laurent; Thi, Meilinh; Siebert, R.

doi:10.1117/12.831742

Cited by 1 publication

(3 citation statements)

References 12 publications

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“…They match pretty well, as it was already observed in [13] for variations of the optical parameters: µ s , µ a and g. In all cases, the simulated and experimental results show a similar shape. For the monolayer phantoms, the highest yield in fluorescence light collection is measured at a height of about 1.4 mm; for the simulated data it is around 1.6 mm.…”

Section: Resultssupporting

confidence: 86%

“…First comparisons between simulated and measured results on monolayer phantoms have already been presented in [13]. Variation of optical coefficients, such as diffusion, absorption and anisotropy of diffusion coefficients have been compared for simulated and measured phantoms.…”

Section: Resultsmentioning

confidence: 99%

“…Special effort has been done to evaluate and minimize boundary effects of the inclusions. More phantom details are presented in [13].…”

Section: Introductionmentioning

confidence: 99%

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Development of an autofluorescent probe for brain cancer: probe characterization thanks to phantom studies

Leh

Charon

Duval

et al. 2010

Design and Performance Validation of Phantoms Used in Conjunction With Optical Measurement of Tissue II

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Glioblastoma are brain tumors currently incurable, however, optimized treatment gives better prognosis and quality of life. In case of surgical treatment, there is still need to help surgeons to determine whether a tissue is tumorous or not. Within the framework of the design of a new autofluorescence probe for this issue, optically calibrated gel phantoms have been developed using "tumorous" inclusions in a "healthy" environment. Depending on "tumor" shape, size and localization, the sensitivity of the probe is evaluated. The probe sensitivity for fluorescence spectroscopy will be presented. The probe configuration is also taken into account and compared to simulated results.

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%