Development of an effective and safe topical anti-inflammatory gel containing Jatropha gossypiifolia leaf extract: Results from a pre-clinical trial in mice

Xavier-Santos, Jacinthia Beatriz; Félix-Silva, Juliana; Gomes, Jacyra A.S.; Fernandes, Júlia Morais; Garcia, Vinícius Barreto; Araújo-Júnior, Raimundo F. de; Zucolotto, Silvana Maria; Silva-Júnior, Arnóbio Antônio da; Fernandes-Pedrosa, Matheus de Freitas

doi:10.1016/j.jep.2018.09.007

Cited by 30 publications

(16 citation statements)

References 40 publications

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“…After the model was established successfully, the animals were immediately sacrificed, and both ears were removed. The samples were immediately weighed after being punched (Xavier-Santos et al, 2018). The following formula was used to calculate the degree of the ear swelling:…”

Section: The Xylene-induced Mouse Ear Swellingmentioning

confidence: 99%

Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway

Gan

et al. 2021

Front. Pharmacol.

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Burn ointment (BO) is a clinically useful medicine for the treatment of burns and scalds. However, there is no enough scientific evidence to report the effect of BO on wound healing and its analgesic and anti-inflammatory efficacy. The aim of this work was to evaluate the anti-inflammatory and analgesic efficacy of BO and to reveal the potential wound healing properties and related mechanisms of BO. In this work, the content of active ingredients of BO was determined by high-performance liquid chromatography (HPLC). Two animal models of inflammation were used to study its anti-inflammatory activity, and a hot plate method was used to evaluate its analgesic effect. In addition, mouse incision and rat burn models were used to investigate the effect of BO on the anti-inflammatory and wound healing mechanisms. The results showed that BO was safe for topical application, and BO could significantly inhibit auricular swelling in mice and paw swelling in rats and significantly prolong the latency period of paw licking in the hot plate experiment in mice. It can also accelerate wound healing and repair scars by promoting the formation of new epithelial tissues in rat burn models. In addition, BO significantly downregulated the serum level of TNF-α and significantly increased the serum levels of VEGF and TGF-β1. Also, BO promoted the expression of collagen I and increased the ratio in p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR pathways. Our results demonstrate the safety and efficacy of BO and suggest that activation of the PI3K/AKT/mTOR signaling pathway may play an important role in the promotion of wound healing by BO.

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Section: The Xylene-induced Mouse Ear Swellingmentioning

confidence: 99%

Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway

Gan

et al. 2021

Front. Pharmacol.

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“…The dermal irritation/corrosion properties of the developed formulation were assessed in mice according to the methods previously described in the literature with some modifications. 38,39 Mice were anesthetized by intraperitoneal injection of 2% chloral hydrate (0.15 mL/10 g) and their two sides of the spinal (approximately 3 cm 2 ) were shaved 24 h before the test without causing tissue damage. Subsequently, filter papers (2 cm 2 ) were impregnated with 0.2 mL of formulation and then positioned on the dorsum of the mice, and fixed with hypersensitive tape.…”

Section: Acute Dermal Irritation Testmentioning

confidence: 99%

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Niu¹,

Yuan²,

Chen³

et al. 2020

IJN

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“…The topical administration of anti-inflammatory agents only gives a local effect on the injured part, thus reducing the side effects (7). Nevertheless, the systemic effects of the topical administered medicine depend on the skin penetration ability to enter the circulation or absorb into the deeper tissue to inhibit cyclooxygenase activity (9,10). There are many preparations available for topical administration, such as cream, ointment, Copyright © 2021, Author(s).…”

Section: Introductionmentioning

confidence: 99%

“…and gel. Gel preparations are more preferable due to their good distribution on the skin, cooling effect, absence of physiological inhibition against the hair function, washable property, and good medicine (active compounds) release (8,9,11). The active compounds used in this study is the nanoparticle from arabica coffee grounds (Coffea arabica L.) owing to having active compounds such as phenolics (chlorogenate acid (12) and flavonoid (13) with total phenolics 1246.90 µgGAE/g (14), alkaloids (15), carotenoids, saponins (16,17) and others (18,19).…”

Section: Introductionmentioning

confidence: 99%

Optimizing Anti-inflammatory Activities of Arabica Coffee Ground (Coffea arabica L.) Nanoparticle Gel

Nurman

Yulia

Irmayanti

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Arabica coffee ground nanoparticles gel is known to possess good physicochemical properties and high phenolic contents in which the phenolics are famous for their anti-inflammatory activities. Objectives: : This study aimed to investigate the anti-inflammatory activities of the arabica coffee ground nanoparticles gel on carrageenan-induced male mice for 6 h. The positive control was commercial medicine (Voltaren gel), and the control negative was base gel. Methods: The inflammatory inhibition of arabica coffee ground nanoparticles gel is determined by measuring the edema volume of the carrageenan-induced mice foot using a plethysmometer. Anti-inflammatory activities of arabica coffee ground nanoparticles gel were optimized using Box-Behnken Design of the response surface methodology. Results: The anti-inflammatory activities or inflammatory inhibition of arabica coffee ground nanoparticles gel was determined by measuring the edema volume of the carrageenan-induced mice foot. The increase of edema volume of the mice foot from the first to 180th min was caused by the release of inflammation mediator such as histamine, prostaglandins, bradykinins, and serotonin on the tissue; meanwhile, at the 240th min, the edema of the mice foot experienced a decrease due to the inhibition of prostaglandins synthesis to the tissue. The obtained results indicated that the arabica coffee ground nanoparticles gel has average value of anti-inflammatory activities of 27.75%. The obtained optimum formulation is 0.500% Carbopol 940, 0.400% triethanolamine, and 2.313% nanoparticle, giving 29.360% and 29.670% for the predicted and experimental inflammatory inhibition values, with 0.812 desirability value, respectively. Conclusions: The Box-Behnken design can be used to determine the optimal gel formulation of arabica coffee grounds for inflammatory inhibition.

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Development of an effective and safe topical anti-inflammatory gel containing Jatropha gossypiifolia leaf extract: Results from a pre-clinical trial in mice

Abstract: The results demonstrate the potentiality of J. gossypiifolia gel as a promising safe and effective topical anti-inflammatory agent for treatment of cutaneous inflammatory diseases.

Cited by 30 publications

References 40 publications

Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway

Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Optimizing Anti-inflammatory Activities of Arabica Coffee Ground (Coffea arabica L.) Nanoparticle Gel

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