Development of an electrochemical label-free biosensor for microRNA-125a detection using pencil graphite electrode modified with different carbon nanomaterials

Yammouri, Ghita; Mandli, Jihane; Mohammadi, Hasna; Amine, Aziz

doi:10.1016/j.jelechem.2017.10.012

Cited by 48 publications

(21 citation statements)

References 47 publications

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“…Similarly, the application of potential barrier for chromium monitoring can further develops the linear range and allows its determination at ppt level. Carbon black is used as the cheapest nanomaterial (1 euro/kg) [ 38 ] and is advantageously compared to the other nanomaterials for different applications.…”

Section: Discussionmentioning

confidence: 99%

“…The developed sensor showed great importance for detecting Cr(VI) concentration as low as 1.04 µg·L −1 with high accuracy [ 35 ]. To achieve low detection limits for Cr(VI) and high sensitivities, carbon black can be used for electrodes modification owing to its several advantages, such as large surface area, environmentally friendly, high chemical and mechanical stability, high electrical conductivity and very low cost [ 36 , 37 , 38 ]. Besides, the utilization of such nanomaterial for sensor modification leads to a great enhancement in sensitivity.…”

Section: Electrochemical Sensors For Hexavalent Chromium Determinamentioning

confidence: 99%

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Recent Advances in Electrochemical Monitoring of Chromium

Hilali

Mohammadi

Amine

et al. 2020

Sensors

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The extensive use of chromium by several industries conducts to the discharge of an immense quantity of its various forms in the environment which affects drastically the ecological and biological lives especially in the case of hexavalent chromium. Electrochemical sensors and biosensors are useful devices for chromium determination. In the last five years, several sensors based on the modification of electrode surface by different nanomaterials (fluorine tin oxide, titanium dioxide, carbon nanomaterials, metallic nanoparticles and nanocomposite) and biosensors with different biorecognition elements (microbial fuel cell, bacteria, enzyme, DNA) were employed for chromium monitoring. Herein, recent advances related to the use of electrochemical approaches for measurement of trivalent and hexavalent chromium from 2015 to 2020 are reported. A discussion of both chromium species detections and speciation studies is provided.

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Section: Discussionmentioning

confidence: 99%

Section: Electrochemical Sensors For Hexavalent Chromium Determinamentioning

confidence: 99%

Recent Advances in Electrochemical Monitoring of Chromium

Hilali

Mohammadi

Amine

et al. 2020

Sensors

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“…In the design of an electrochemical label-free biosensor detecting microRNA-125a, Yammouri et al used PGE modified with several carbon nanomaterials, including carbon black (CB), multiwalled carbon nanotubes (MWCNT) and graphene oxide (GO). Their lowest LOD was 10 pM (1 pg/mL) obtained using PGE modified with CB providing a linear range between 1 nM and 2 μM [33]. Exploratory use of pretreated bare carbonaceous electrodes in electrochemical biosensors for healthcare applications introduced key questions; could we detect molecules with high efficiency on surface-modified GCE, PGE or SPCE and would this surpass biosensors based on alternative 2D nanomaterials?…”

Section: Toward the Use Of Graphenic Nanomaterials In Biosensingmentioning

confidence: 99%

Impact of nano-morphology, lattice defects and conductivity on the performance of graphene based electrochemical biosensors

Tite¹,

Chiticaru²,

Burns³

et al. 2019

J Nanobiotechnol

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Diverse properties of graphenic materials have been extensively explored to determine properties that make good electrochemical nanomaterial-based biosensors. These are reviewed by critically examining the influence of graphene nano-morphology, lattice defects and conductivity. Stability, reproducibility and fabrication are discussed together with sensitivity and selectivity. We provide an outlook on future directions for building efficient electrochemical biosensors.

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“…There have been many studies based on electrochemical detection for miRNA detection in the literature . Li et al.…”

Section: Introductionmentioning

confidence: 99%

“…There have been many studies based on electrochemical detection for miRNA detection in the literature [35][36][37][38][39][40][41][42][43][44][45][46]. Li et al [31] developed label-free electrochemical biosensor for miRNAs detection by measuring the guanine oxidation signal on a multi-walled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE).…”

mentioning

confidence: 99%

Ionic Liquid Modified Single‐use Electrode Developed for Voltammetric Detection of miRNA‐34a and its Application to Real Samples

et al. 2019

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The ionic liquid (IL) modified chemically activated (CA) pencil graphite electrodes (PGEs) were developed for label‐free voltammetric detection of miRNA‐34a, and implemented to the real samples. Firstly, the electrochemical characterization of unmodified PGE, CA‐PGE, IL‐PGE and IL‐CA‐PGE was performed by cyclic voltammetry (CV) as well as their DNA binding capacity was studied by electrochemical impedance spectroscopy (EIS) technique. The microscopic characterization of the surface of each electrodes was investigated by scanning electron microscopy (SEM). Differential pulse voltammetry (DPV) technique was used for measuring the oxidation signal of guanine in order to perform a label‐free voltammetric monitoring of a full‐match hybridization specific to miRNA‐34a. The selectivity of biosensor was tested against to miRNA‐155, miRNA‐660 as well as to the mismatch sequence of miRNA‐34a. The further selectivity of this proposed biosensor was studied in the mixture of samples containing miRNA‐34a with other miRNAs (1 : 1). The voltammetric detection of miRNA‐34a was also explored in the artificial serum medium as fetal bovine serum (FBS) and also in total RNA samples isolated from HUH‐7 human hepatocellular carcinoma cell line.

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Development of an electrochemical label-free biosensor for microRNA-125a detection using pencil graphite electrode modified with different carbon nanomaterials

Cited by 48 publications

References 47 publications

Recent Advances in Electrochemical Monitoring of Chromium

Recent Advances in Electrochemical Monitoring of Chromium

Impact of nano-morphology, lattice defects and conductivity on the performance of graphene based electrochemical biosensors

Ionic Liquid Modified Single‐use Electrode Developed for Voltammetric Detection of miRNA‐34a and its Application to Real Samples

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