Development of an implantable PCL/alginate bilayer scaffold to prevent secondary infections

Baek, Seungho; Park, Heekyung; Chen, Keyao; Park, Hakyoung; Lee, Dong-Hyun

doi:10.1007/s11814-019-0459-8

Cited by 7 publications

(3 citation statements)

References 52 publications

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“…In the top layer, Alg plays the role of an antifouling and anti‐adhesive layer against other organs [30] . Alg can form a water‐abundant layer owing to its great hydrophilicity, which is capable of preventing foreign cells and proteins from adhering [31,32] . Furthermore, it has weak tissue‐adhesive properties due to strong electrorepulsion on the interface of the inner (i.e., mucin)/outer layer of the colon tissue.…”

Section: Resultsmentioning

confidence: 99%

Mucoadhesive and antifouling Janus polysaccharide film for prevention of colorectal cancer recurrence post‐surgery

Lee,

Seo,

Park

et al. 2024

BMEMat

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Colorectal cancer is one of the most common cancers, and current treatment options include surgery, chemotherapy, and radiation therapy. Most patients undergo surgery, which often requires extensive resection of the colon to prevent recurrence and metastasis of residual malignant tumor cells, leading to postoperative pain and discomfort in daily routines. Although versatile therapeutic patches have been developed to induce tumor apoptosis, achieving both great adhesiveness on the mucus layers of the colon tissue and anti‐cell/tissue adhesion to other surrounding organs remains a challenge. Herein, we report a Janus polysaccharide film comprising two polymers: mussel‐inspired catechol‐conjugated chitosan (Chi‐C) with muco‐adhesiveness, and alginate (Alg) with anti‐adhesion property. The Chi‐C and Alg polymers form a stably entangled bilayer film via electrostatic interactions. The Janus film shows a strong tissue adhesive strength of ∼10 kPa for the Chi‐C layer and weak strength of ∼1 kPa for the Alg layer. Particularly, the Janus film encapsulating an anti‐cancer drug exhibits a directional release profile to the tumor site, which is effective for triggering tumor death in in vivo colorectal tumor resection model. Ultimately, such anti‐cancer material strategies using bilayered structures are promising for advanced tumor therapy.

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Section: Resultsmentioning

confidence: 99%

Mucoadhesive and antifouling Janus polysaccharide film for prevention of colorectal cancer recurrence post‐surgery

Lee,

Seo,

Park

et al. 2024

BMEMat

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“…These crosslinking reactions are nontoxic and are advantageous because they can be used to control the mechanical properties of the polymer [ 104 ]. Nanofiber-type anti-adhesion barriers have recently been developed using electrospinning, and furthermore, effective anti-adhesion barriers have been developed by loading materials with drugs with anti-adhesion effects [ 26 , 106 , 107 ].…”

Section: Polymers As Materials For Anti-adhesion Barriersmentioning

confidence: 99%

Biomaterials to Prevent Post-Operative Adhesion

et al. 2020

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Surgery is performed to treat various diseases. During the process, the surgical site is healed through self-healing after surgery. Post-operative or tissue adhesion caused by unnecessary contact with the surgical site occurs during the normal healing process. In addition, it has been frequently found in patients who have undergone surgery, and severe adhesion can cause chronic pain and various complications. Therefore, anti-adhesion barriers have been developed using multiple biomaterials to prevent post-operative adhesion. Typically, anti-adhesion barriers are manufactured and sold in numerous forms, such as gels, solutions, and films, but there are no products that can completely prevent post-operative adhesion. These products are generally applied over the surgical site to physically block adhesion to other sites (organs). Many studies have recently been conducted to increase the anti-adhesion effects through various strategies. This article reviews recent research trends in anti-adhesion barriers.

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“…Hence, they are not suitable for burn wounds, which usually display high exudate levels. One of the approaches to resolve this barrier is enhancement hydrophilicity PCL nanofibers via blending with hydrophilic polymers like polyvinyl pyrrolidone (PVP) 21 , gelatin 22 , polyethylene glycol 23 , and cellulose acetate 24 , etc 25 . To improve the performance of PCL nanofibers in wound dressing, incorporating an antibacterial agent into them has been suggested, which showed promising results.…”

Section: Introductionmentioning

confidence: 99%

Kiwi extract-incorporated poly(ɛ-caprolactone)/cellulose acetate blend nanofibers for healing acceleration of burn wounds

Bayat

Fallah-Darrehchi

Zahedi

et al. 2022

Journal of Biomaterials Science, Polymer Edition

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Antioxidant, antibacterial, and antitoxic ingredients extracted from herbs and fruits have shown promising effects in an exhaustive wound healing process. Due to Kiwi extract possess ingredients including quercetin, lutein, vitamins C (ascorbic acid) and E, actinidin, folate, dietary fiber, and potassium characterized in kiwi are known as an antioxidant and antibacterial components. To enhance the performance of the kiwi extract at burn wound healing, the kiwi extract was incorporated into polycaprolactone/cellulose acetate (PCL/CA-1KE) nanofibers. The PCL/CA-1KE with an optimized diameter (≅ 420𝑛𝑚) showed porosity ≅ 70% with an acceptable surface and bulk hydrophilicity, which its water contact angle and water uptake were 61° and 221%, respectively. The release mechanism of kiwi extract from nanofibers was predicted via Fick's laws of diffusion because the correlation coefficient (R 2 ) of fitting of the Pappas model on release behavior of kiwi extract in vitro media was 0.92 (the highest R 2 between the models). Cell viability and cell attachment of fibroblast cells on the PCL/CA-1KE nanofibers were evaluated by MTT assay and micrograph SEM images, respectively. The fastest wound closure rate among the sample was related to PCL/CA-1KE that after 21 days, was ≅ 4%. Histopathology of wounds treated by PCL/CA-1KE showed epidermal proliferation and increased epidermal layer at 7 days post-treatment.

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Development of an implantable PCL/alginate bilayer scaffold to prevent secondary infections

Cited by 7 publications

References 52 publications

Mucoadhesive and antifouling Janus polysaccharide film for prevention of colorectal cancer recurrence post‐surgery

Mucoadhesive and antifouling Janus polysaccharide film for prevention of colorectal cancer recurrence post‐surgery

Biomaterials to Prevent Post-Operative Adhesion

Kiwi extract-incorporated poly(ɛ-caprolactone)/cellulose acetate blend nanofibers for healing acceleration of burn wounds

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