Development of an on-column enrichment technique based on C18-functionalized magnetic silica nanoparticles for the determination of lidocaine in rat plasma by high performance liquid chromatography

Chu, Bin; Lou, Dujuan; Peng, Yu; Hu, Song; Shen, Shun

doi:10.1016/j.chroma.2011.08.053

Cited by 36 publications

(13 citation statements)

References 28 publications

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“…Since lidocaine overdose can damage the heart and nervous system, highly sensitive and reliable monitors for lidocaine are extremely important for clinical purposes [41]. For this reason, lidocaine has been analyzed using techniques such as LC/MS [42], HPLC [43][44][45], and GC-MS [46,47]. Previous experiments have shown that determining the amount of a tertiary amine is possible using NNO.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Oxidation of Amines Using a Nitroxyl Radical Catalyst and the Electroanalysis of Lidocaine

et al. 2018

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The nitroxyl radical of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) can electro-oxidize not only alcohols but also amines. However, TEMPO has low activity in a neutral aqueous solution due to the large steric hindrance around the nitroxyl radical, which is the active site. Therefore, nortropine N-oxyl (NNO) was synthesized to improve the catalytic ability of TEMPO and to investigate the electrolytic oxidation effect on amines from anodic current changes. Ethylamine, diethylamine, triethylamine, tetraethylamine, isopropylamine, and tert-butylamine were investigated. The results indicated that TEMPO produced no response current for any of the amines under physiological conditions; however, NNO did function as an electrolytic oxidation catalyst for diethylamine, triethylamine, and isopropylamine. The anodic current depended on amine concentration, which suggests that NNO can be used as an electrochemical sensor for amine compounds. In addition, electrochemical detection of lidocaine, a local anesthetic containing a tertiary amine structure, was demonstrated using NNO with a calibration curve of 0.1-10 mM.around the nitroxyl radical active site, and an adequate response current could not be obtained under physiological conditions. Iwabuchi and colleagues [22] reported that 2-azaadamantane N-oxyl (AZADO), which lacks steric hindrance around the active site, exhibited greater activity than TEMPO in organic synthesis reactions. Less-hindered nitroxyl radicals with various steric environments have been synthesized, and those with less bulky functionality exhibited greater activity [23][24][25][26]. Therefore, nortropine N-oxyl (NNO), which was modeled on AZADO, was synthesized in one step as a novel nitroxyl radical compound [27]. The NNO was capable of electrolytic oxidation of alcohols in neutral aqueous solutions. The NNO could be used in place of enzymes, allowing non-enzymatic analysis of glucose under physiological conditions [27]. Phenylboronic acid derivatives have been investigated as glucose sensors [28][29][30]. Phenylboronic acid (PBA) spontaneously binds with a moiety containing a diol [31]. The structural and electrical changes in PBA derivative probes when PBA bonds with the diol moiety can be used for glucose detection [32][33][34]. However, these probes had low specificity for glucose and did not respond under physiological conditions. Superiority of NNO was demonstrated from this report [27]. In contrast, TEMPO has catalytic oxidation ability toward amines as well as alcohols [35][36][37]. Therefore, the present study examined the electrolytic oxidation effect of NNO on amines under physiological conditions and compared the results with those obtained with TEMPO. The results demonstrated that NNO was a good electrochemical analysis probe for secondary and tertiary amines and for isopropylamine under physiological conditions (Figure 1). The oxoammonium ion, which is the active species, reacts with the amine to form hydroxylamine. The catalyst regenerates by reoxidation of hydroxylamine. Furthermore, ele...

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Section: Resultsmentioning

confidence: 99%

Electrochemical Oxidation of Amines Using a Nitroxyl Radical Catalyst and the Electroanalysis of Lidocaine

et al. 2018

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“…Considering the high back-pressure and clogging of the sorbent in conventional SPE [88][89][90], batch SPE is gradually becoming popular in analytical chemistry. Different from classical SPE, in batch SPE, sorbents are not packed into cartridges, but incubated directly with the samples.…”

Section: Molecularly-imprinted Polymer-solid Phase Extraction (Mispe)mentioning

confidence: 99%

Recent advances in analysis of phthalate esters in foods

Yang

Wang

et al. 2015

TrAC Trends in Analytical Chemistry

131

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“…Consequently, it is interesting to explore the feasibility of using short‐chain alkoxysilane modified silica as the SPE adsorbent for extracting organic compounds. Additionally, PTSA enables the incorporation of methoxysilanes onto the surface of silica in a much shorter time (1 h) , while effective grafting would last for many hours, and even more than 24 h, in traditional synthesis processes . The time‐saving merit increases the significance of this investigation.…”

Section: Introductionmentioning

confidence: 99%

“…To prevent condensation of silane coupling agents and improve the grafting efficiency, the modification process is often performed in an anhydrous solvent. Many functional alkoxysilanes have been modified on the surface of silica by modification in anhydrous conditions [21,22]. The functionalization of long-chain alkoxysilanes, such as octadecylalkoxysilane, is one of the most common modification approaches because it can provide a very effective hydrophobic interaction for the extraction of most organic compounds in aqueous solution [17,23,24].…”

Section: Introductionmentioning

confidence: 99%

Rapid preparation of methyltrimethoxy‐modified magnetic mesoporous silica as an effective solid‐phase extraction adsorbent

Qin

Fan

et al. 2018

J of Separation Science

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A time-saving method was applied to synthesize methyltrimethoxy-modified magnetic mesoporous silica with or without p-toluenesulfonic acid as the catalyst for magnetic solid-phase extraction. The synthesized materials were systematically characterized. Results demonstrated that methyltrimethoxy modified magnetic mesoporous silica with p-toluenesulfonic acid as the catalyst has a relatively smaller aperture and extreme hydrophobicity (water contact angle of 135°). To evaluate the feasibility of these prepared materials as effective adsorbents, it was combined with gas chromatography and electron capture detection to determine 26 polychlorinated biphenyls in environmental water. The result revealed that methyltrimethoxy modified magnetic mesoporous silica with p-toluenesulfonic acid as the catalyst had the best extraction efficiency and recovery. Under the optimized extracted conditions, the proposed method showed good linearity within the concentration range of 5 to 200 ng/L with correlation coefficients of 0.9969 to 0.9999. The limits of detection and quantification based on signal-to-noise ratios of 3 and 10 were in the range of 0.16 to 0.91 and 0.52 to 3.0 ng/L, respectively. The polychlorinated biphenyl concentrations in environmental water samples were successfully determined using the developed method. PCB008 and PCB110 were 4.05 and 8.52 ng/L in Red-Star lake water (Hubei Province, China), respectively.

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Development of an on-column enrichment technique based on C18-functionalized magnetic silica nanoparticles for the determination of lidocaine in rat plasma by high performance liquid chromatography

Cited by 36 publications

References 28 publications

Electrochemical Oxidation of Amines Using a Nitroxyl Radical Catalyst and the Electroanalysis of Lidocaine

Electrochemical Oxidation of Amines Using a Nitroxyl Radical Catalyst and the Electroanalysis of Lidocaine

Recent advances in analysis of phthalate esters in foods

Rapid preparation of methyltrimethoxy‐modified magnetic mesoporous silica as an effective solid‐phase extraction adsorbent

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