Development of an oral push&amp;ndash;pull osmotic pump of fenofibrate-loaded mesoporous silica nanoparticles

Zhao, Zongzhe; Wu, Chao; Zhao, Ying; Hao, Yanna; Liu, Ying; Zhao, Wei

doi:10.2147/ijn.s76755

Cited by 12 publications

(2 citation statements)

References 35 publications

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“…Bioavailability of PPOP increased by approximately 60.32% compared with the reference drug. [ 97 ] 12 Ibuprofen Mesoporous silica (MCM 41). The adsorption method’ The incipient wetness The rapid release was observed in the IBP-loaded MSNs.…”

Section: Drug With Good Gfa (Ggfa Drug)mentioning

confidence: 99%

Characterization of Drug with Good Glass-Forming Ability Loaded Mesoporous Silica Nanoparticles and Its Impact Toward in vitro and in vivo Studies

Budiman,

Anastasya,

Handini

et al. 2024

IJN

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Solid oral dosage forms are mostly preferred in pharmaceutical formulation development due to patient convenience, ease of product handling, high throughput, low manufacturing costs, with good physical and chemical stability. However, 70% of drug candidates have poor water solubility leading to compromised bioavailability. This phenomenon occurs because drug molecules are often absorbed after dissolving in gastrointestinal fluid. To address this limitation, delivery systems designed to improve the pharmacokinetics of drug molecules are needed to allow controlled release and target-specific delivery. Among various strategies, amorphous formulations show significantly high potential, particularly for molecules with solubility-limited dissolution rates. The ease of drug molecules to amorphized is known as their glass-forming ability (GFA). Specifically, drug molecules categorized into class III based on the Taylor classification have a low recrystallization tendency and high GFA after cooling, with substantial “glass stability” when heated. In the last decades, the application of mesoporous silica nanoparticles (MSNs) as drug delivery systems (DDS) has gained significant attention in various investigations and the pharmaceutical industry. This is attributed to the unique physicochemical properties of MSNs, including high loading capacity, recrystallization inhibition, excellent biocompatibility, and easy functionalization. Therefore, this study aimed to discuss the current state of good glass former drug loaded mesoporous silica and shows its impact on the pharmaceutical properties including dissolution and physical stability, along with in vivo study. The results show the importance of determining whether mesoporous structures are needed in amorphous formulations to improve the pharmaceutical properties of drug with a favorable GFA.

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Section: Drug With Good Gfa (Ggfa Drug)mentioning

confidence: 99%

Characterization of Drug with Good Glass-Forming Ability Loaded Mesoporous Silica Nanoparticles and Its Impact Toward in vitro and in vivo Studies

Budiman,

Anastasya,

Handini

et al. 2024

IJN

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show abstract

“…MSNs are unique because they are biocompatible, have a large surface area, a large pore volume, and are highly physicochemically stable. In MSN pores, drugs are better solubilized and dispersed . Zhao et al reported that a push–pull osmotic pump (PPOP) mechanism can be used to control drug release as well as to ensure that the plasma concentration does not fluctuate.…”

Section: Applications Of Mesoporous Materials In Various Fieldsmentioning

confidence: 99%

Synthesis and Application of Mesoporous Materials: Process Status, Technical Problems, and Development Prospects: A Mini-Review

Liu

Wang

et al. 2023

Energy Fuels

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The world today is witnessing a new technological revolution, particularly in the area of new materials. Different types of materials often have different characteristics and uses. Mesoporous materials have a large specific surface area, easily modifiable inner and outer surfaces, tunable pore size and pore channels, and good biocompatibility and thermodynamic stability, thus emerging as a new candidate material in the chemical research community. The presence of mesopores facilitates the rapid diffusion of macromolecules, reduces resistance to mass transfer, and provides different properties depending on the pore size, making mesoporous materials a potential candidate for a wide range of applications. This paper reviews the recent methods used to synthesize mesoporous materials, including hydrothermal synthesis, microwave synthesis, the sol−gel method, the phase conversion method, and the templating method. The soft templating method is introduced in detail, including bulk self-assembly, solvent evaporation-induced self-assembly, solution-based nanoprecipitation, interfacial self-assembly in a solution, and emulsion template self-assembly. The current status of the processes related to mesoporous materials in the fields of biomedicine, environmental and energy, electrochemical energy storage, and gas separation is elaborated. Finally, the technical issues and future directions in the synthesis and application of mesoporous materials are briefly discussed.

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Mesoporous materials and technologies for development of oral medicine

Shen

Dong

Letchmanan

et al. 2017

Nanostructures for Oral Medicine

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Development of an oral push–pull osmotic pump of fenofibrate-loaded mesoporous silica nanoparticles

Cited by 12 publications

References 35 publications

Characterization of Drug with Good Glass-Forming Ability Loaded Mesoporous Silica Nanoparticles and Its Impact Toward in vitro and in vivo Studies

Characterization of Drug with Good Glass-Forming Ability Loaded Mesoporous Silica Nanoparticles and Its Impact Toward in vitro and in vivo Studies

Synthesis and Application of Mesoporous Materials: Process Status, Technical Problems, and Development Prospects: A Mini-Review

Mesoporous materials and technologies for development of oral medicine

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