Development of Anti-bacterial PVA/Starch Based Hydrogel Membrane for Wound Dressing

Hassan, Awais; Niazi, Muhammad Bilal Khan; Hussain, Arshad; Farrukh, Sarah; Ahmad, Tahir

doi:10.1007/s10924-017-0944-2

Cited by 113 publications

(47 citation statements)

References 28 publications

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“…International Journal of Polymer Science the case of wound dressing, the shelf life of a hydrogel is not the problem, as the hydrogel is used once for a short period [29]. Eventually, we noticed that the original shape of the HG was maintained after impregnation of the plant extract in HG, which may be explained by the permanent junction-induced mechanical strength after chemical cross-linking [30].…”

mentioning

confidence: 99%

Fabrication of an Original Transparent PVA/Gelatin Hydrogel: In Vitro Antimicrobial Activity against Skin Pathogens

Imtiaz

Niazi

Fasim

et al. 2019

International Journal of Polymer Science

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The design of actively efficient and low-toxicity formulations against virulent bacterial strains causing skin infections remains a challenging task. The aim of the present study was to develop and evaluate in vitro a hydrogel impregnated with a known plant extract for topical applications against major skin bacteria. A poly(vinyl alcohol) (PVA)/gelatin hydrogel, namely HG, was prepared by esterification following the solution casting method. The gelling process was realized by cross-linking the synthetic polymer PVA and the biopolymer gelatin in the presence of hydrochloric acid (HCl). A crude extract of Nigella sativa seeds was then encapsulated in HG, and the resulting HGE was characterized morphologically (by Scanning Electron Microscopy (SEM)), structurally (by X-ray powder diffraction (XRD) and Fourier Transform Infrared (FTIR) spectroscopy), behaviorally (by swelling behavior), and biologically (by the agar well diffusion method). The results of HGE were compared to HG and HG impregnated with 10% acetic acid (HGAA). SEM sections of HGE revealed a dense and porous surface, suggesting a good hydrophilicity. X-ray diffractograms indicated that HGE and HG had a similar degree of crystallinity. FTIR spectra confirmed that esterification occurred between PVA and gelatin suggesting that the amine group is involved in the intercalation of the plant extract components in HG. Further, HGE was found to be as wettable and swellable as HG, suggesting a good biocompatibility. Eventually, HGE exerted a pronounced inhibitory effect against two major skin pathogens, the Gram-negative Pseudomonas aeruginosa and the Gram-positive Staphylococcus aureus, suggesting a good extract release. Taken together, the experimental data indicated that HGE might be a promising wound dressing.

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confidence: 99%

Fabrication of an Original Transparent PVA/Gelatin Hydrogel: In Vitro Antimicrobial Activity against Skin Pathogens

Imtiaz

Niazi

Fasim

et al. 2019

International Journal of Polymer Science

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“…Due to their inherent properties, hydrogels are able to efficiently encapsulate and deliver in a controlled release manner [14]. Additionally, these materials must possess properties similar to normal skin: not possess toxins, provide an environment that prevents drying of the wound, reduce the penetration of bacteria, avoid losses of heat, water, proteins and red blood cells, in addition to promoting a rapid healing [36,37]. Thus, the use of biomaterials for the treatment of wounds is an area of interest for the scientific and medical community.…”

Section: Introductionmentioning

confidence: 99%

Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

et al. 2019

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This research proposes the rational modeling, synthesis and evaluation of film dressing hydrogels based on polyvinyl alcohol crosslinked with 20 different kinds of dicarboxylic acids. These formulations would allow the sustained release of simultaneous bioactive compounds including allantoin, resveratrol, dexpanthenol and caffeic acid as a multi-target therapy in wound healing. Interaction energy calculations and molecular dynamics simulation studies allowed evaluating the intermolecular affinity of the above bioactive compounds by hydrogels crosslinked with the different dicarboxylic acids. According to the computational results, the hydrogels crosslinked with succinic, aspartic, maleic and malic acids were selected as the best candidates to be synthesized and evaluated experimentally. These four crosslinked hydrogels were prepared and characterized by FTIR, mechanical properties, SEM and equilibrium swelling ratio. The sustained release of the bioactive compounds from the film dressing was investigated in vitro and in vivo. The in vitro results indicate a good release profile for all four analyzed bioactive compounds. More importantly, in vivo experiments suggest that prepared formulations could considerably accelerate the healing rate of artificial wounds in rats. The histological studies show that these formulations help to successfully reconstruct and thicken epidermis during 14 days of wound healing. Moreover, the four film dressings developed and exhibited excellent biocompatibility. In conclusion, the novel film dressings based on hydrogels rationally designed with combinatorial and sustained release therapy could have significant promise as dressing materials for skin wound healing.

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“…PVDF is a semi-crystalline polymer which displays exceptional thermal, chemical, and oxidation resistances vis-a-vis corrosive chemicals such as acids, bases, oxidants, and halogens. The crystalline phase of the polymer offers thermal stability, whereas the amorphous phase provides the required membrane flexibility and good mechanical and film-forming properties [ 13 , 14 , 15 , 16 ]. In terms of hydrophobicity, although PVDF lacks PP and PTFE, the selection of suitable solvents for PVDF is facile.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Blend PVDF Membranes, and the Effect of Polymer Concentration and Blend Composition

et al. 2018

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In this work, PVDF homopolymer was blended with PVDF-co-HFP copolymer and studied in terms of morphology, porosity, pore size, hydrophobicity, permeability, and mechanical properties. Different solvents, namely N-Methyl-2 pyrrolidone (NMP), Tetrahydrofuran (THF), and Dimethylformamide (DMF) solvents, were used to fabricate blended PVDF flat sheet membranes without the introduction of any pore forming agent, through a non-solvent induced phase separation (NIPS) technique. Furthermore, the performance of the fabricated membranes was investigated for pressure and thermal driven applications. The porosity of the membranes was slightly increased with the increase in the overall content of PVDF and by the inclusion of PVDF copolymer. Total PVDF content, copolymer content, and mixed-solvent have a positive effect on mechanical properties. The addition of copolymer increased the hydrophobicity when the total PVDF content was 20%. At 25% and with the inclusion of mixed-solvent, the hydrophobicity was adversely affected. The permeability of the membranes increased with the increase in the overall content of PVDF. Mixed-solvents significantly improved permeability.

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Development of Anti-bacterial PVA/Starch Based Hydrogel Membrane for Wound Dressing

Cited by 113 publications

References 28 publications

Fabrication of an Original Transparent PVA/Gelatin Hydrogel: In Vitro Antimicrobial Activity against Skin Pathogens

Fabrication of an Original Transparent PVA/Gelatin Hydrogel: In Vitro Antimicrobial Activity against Skin Pathogens

Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

Assessment of Blend PVDF Membranes, and the Effect of Polymer Concentration and Blend Composition

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