Atypical hemolytic-uremic syndrome (aHUS), a variant of thrombotic micro angiopathy (TMA), is a life-threatening disease that leads to multiple organ damage with the high rate of maternal mortality or the disability of surviving. Our experience of the clinical course of the disease, launched after delivery, features of multiple organ failure, intensive care unit monitoring and treatment is presented in the article. We suggest, timely diagnosis and early specific anticomplementary therapy with complex and escalation treatment of multiple organ failure, which can be realized only in large multidisciplinary medical centers, can contribute to the improvement of outcomes.