Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating

Nooeaid, Patcharakamon; Li, Wei; Roether, Judith A.; Mouriño, Viviana; Goudouri, Ourania-Menti; Schubert, Dirk W.; Boccaccını, Aldo R.

doi:10.1116/1.4897217

Cited by 32 publications

(19 citation statements)

References 52 publications

(97 reference statements)

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“…Future considerations to minimize the risk of implantassociated infection include the use of tissue engineering technology to embed slow-release antimicrobial or silver nanoparticles into the prosthesis. [63][64][65][66][67][68] Implant failure has been reported in humans following mandibular reconstruction with free fibular grafts because of failure to counteract the complex biomechanical forces (bending, torsional, and shearing) acting on the mandible as a result of the actions of individual masticatory muscles during chewing and the magnitude of forces generated during biting. 42,43 As mentioned previously, biomechanical studies are required to further elucidate the direction and magnitude of the these forces in clinically normal cats to provide information for the optimal design of CAD-CAM customized 3-Dprinted mandibular prostheses to minimize the risk of implant-prosthesis failure.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of a mandibular segmental defect with a customized 3-dimensional–printed titanium prosthesis in a cat with a mandibular osteosarcoma

Liptak¹,

Thatcher²,

Bray³

2017

javma

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CASE DESCRIPTION A 12-year-old neutered male domestic shorthair cat had been treated for a mass arising from the lingual aspect of the caudal right mandibular body. Cytoreductive surgery of the mass had been performed twice over a 2-year period, but the mass recurred following both surgeries. The mass was diagnosed as an osteosarcoma, and the cat was referred for further evaluation and treatment. CLINICAL FINDINGS Clinical findings were unremarkable, except for a 2-cm-diameter mass arising from the lingual aspect of the right mandible and mild anemia and lymphopenia. Pre- and postcontrast CT scans of the head, neck, and thorax were performed, revealing that the osteosarcoma was confined to the caudal right mandibular body, with no evidence of lymph node or pulmonary metastasis. TREATMENT AND OUTCOME The stereolithographic files of the CT scan of the head were sent for computer-aided design and manufacture of a customized 3-D-printed titanium prosthesis. Segmental mandibulectomy was performed, and the mandibular defect was reconstructed in a single stage with the 3-D-printed titanium prosthesis. The cat had 1 minor postoperative complication but had no signs of eating difficulties at any point after surgery. The cat was alive and disease free 14 months postoperatively. CLINICAL RELEVANCE Reconstruction of the mandible of a cat following mandibulectomy was possible with computer-aided design and manufacture of a customized 3-D-printed titanium prosthesis. Cats have a high rate of complications following mandibulectomy, and these initial findings suggested that mandibular reconstruction may reduce the risk of these complications and result in a better functional outcome.

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Section: Discussionmentioning

confidence: 99%

Reconstruction of a mandibular segmental defect with a customized 3-dimensional–printed titanium prosthesis in a cat with a mandibular osteosarcoma

Liptak¹,

Thatcher²,

Bray³

2017

javma

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“…Such structures have a great potential for various biological and medical applications including tissue engineering, 98 gene and biomolecule reservoirs, 99,100 targeted drug and diagnostic agents delivery devices, 101-103 microbioreactors, 104 microbiologically protected platforms, 31 applications requiring guest molecules, 105 and other fields requiring active biointerfaces, which could store chemicals and bioactive materials and release them in a highly controlled process. Such structures have a great potential for various biological and medical applications including tissue engineering, 98 gene and biomolecule reservoirs, 99,100 targeted drug and diagnostic agents delivery devices, 101-103 microbioreactors, 104 microbiologically protected platforms, 31 applications requiring guest molecules, 105 and other fields requiring active biointerfaces, which could store chemicals and bioactive materials and release them in a highly controlled process.…”

Section: B Treatment Of Inorganic Nanostructures For Biomedical Applmentioning

confidence: 99%

“…31,124 Up to date, certain progress was reached in designing and fabrication of complex structures involving carbon nanotubes and graphene flakes on wafer surfaces. 31,124 Up to date, certain progress was reached in designing and fabrication of complex structures involving carbon nanotubes and graphene flakes on wafer surfaces.…”

Section: Growth Of Gram1 and Gram2 Bacteria On Plasma-treated Carbmentioning

confidence: 99%

“…12,13 Biointerfaces are also of a major importance for various industrial applications including fluidised bed bioreactors, 14 food processing 15 and energy conversion devices, [16][17][18] biosensors 19 and sensors, 20 virus detection, 21 biofuel cells, 22 drug delivery devices, 23 and microfluidic 24 and fixed-bed catalytic reactors. 25 In the capacity of biointerfaces, various structures such as highly ordered nanoporous membranes, 26,27 mesoporous carbon beads, 28 nanostructured polymer surfaces, 29 and silica/polymer matrices, 30 as well as bioactive scaffolds for controlled antibiotic release in bone tissue 31 can be used. Further progress in fabrication of complex surfacebound structures made it possible to use the nanoengineered surface covered with carbon nanotubes 32,33 and nanowalls.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma treatment for next-generation nanobiointerfaces

Levchenko¹,

Keidar²,

Mai‐Prochnow³

et al. 2015

Biointerphases

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Energy deficiency, global poverty, chronic hunger, chronic diseases, and environment conservation are among the major problems threatening the whole mankind. Nanostructure-based technologies could be a possible solution. Such techniques are now used for the production of many vitally important products including cultured and fermented food, antibiotics, various medicines, and biofuels. On the other hand, the nanostructure-based technologies still demonstrate low efficiency and controllability, and thus still are not capable to decisively address the global problems. Furthermore, future technologies should ensure lowest possible environmental impact by implementing green production principles. One of the most promising approaches to address these challenges are the sophisticatedly engineered biointerfaces. Here, the authors briefly evaluate the potential of the plasma-based techniques for the fabrication of complex biointerfaces. The authors consider mainly the atmospheric and inductively coupled plasma environments and show several examples of the artificial plasma-created biointerfaces, which can be used for the biotechnological and medical processes, as well as for the drug delivery devices, fluidised bed bioreactors, catalytic reactors, and others. A special attention is paid to the plasma-based treatment and processing of the biointerfaces formed by arrays of carbon nanotubes and graphene flakes.

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“…Different studies have already investigated drug-releasing implant coatings and their influence on the development of peri-implantitis [13], [14], [15]. However , these coatings provide only short term protection against microbial colonization due to insufficient drug loading capacity or inadequate release kinetics.…”

Section: Introductionmentioning

confidence: 99%

The effect of metronidazole releasing polymer coatings on in vitro biofilm formation

et al. 2017

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Abstract:Background: The aim of the study was to evaluate the antibacterial effect of a drug releasing poly (3-hydroxybutyrate) (P(3HB)) implant coating in comparison to pure titanium on Aggregatibacter actinomycetemcomitans as a model periodontopathogen to prevent biofilm formation on implant surfaces. Methods: Titanium discs were coated with P(3HB) containing 5% (w) and 10% (w) of metronidazole, either with and without a P(3HB) topcoat. The biofilm formation was evaluated after 1, 4 and 9 days in a dynamic flow chamber system. Microbial adherence was quantified by determination of bacterial surface coverage. Results: The evaluated formulations of P(3HB)/metronidazole showed an antibacterial effect especially in the first 24 h. Prolonged incubation for 9 days showed reduced bacterial adhesion only on polymer coatings loaded with 10% (w) of metronidazole both with and without topcoat. Conclusions:The evaluated coating formulations can provide protection from an Aggregatibacter actinomycetemcomitans in vitro biofilm formation for the time period which was evaluated.

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Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating

Cited by 32 publications

References 52 publications

Reconstruction of a mandibular segmental defect with a customized 3-dimensional–printed titanium prosthesis in a cat with a mandibular osteosarcoma

Reconstruction of a mandibular segmental defect with a customized 3-dimensional–printed titanium prosthesis in a cat with a mandibular osteosarcoma

Plasma treatment for next-generation nanobiointerfaces

The effect of metronidazole releasing polymer coatings on in vitro biofilm formation

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