Development of Bioadhesive Buccal Tablets of Nicorandil Using a Factorial Approach

Kotadiya, Rajendra; Shah, Karan

doi:10.4274/tjps.galenos.2019.09226

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…All of the tablets passed the USP weight variation test, and their hardness ranged from 4.32 to 8.4 to show that they had enough structural integrity forces to resist the storage and transportation circumstances. 21 In the tablets, we confirmed that this was the case. It was also noted that the hardness value increased as the principal mucoadhesive polymer content increased.…”

Section: Discussionsupporting

confidence: 62%

Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma

PB Suruse,

MB Gawali,

RS Kalkotwar

et al. 2023

Ind. J. Pharm. Edu. Res

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Objectives:The aim of the study was to design, develop, and optimize the buccal tablets containing extract of Terminalia chebula Retz. for the treatment of asthma. Materials and Methods: Buccal tablets were made using the direct compression method, and screening tests with various polymers were run to see how they affected the properties of the tablets. The utilisation of response surface methods, two polymer types, carbopol® and HPMC, were chosen for additional optimization research. Strength of mucoadhesion and % two significant responses that the drug permeated after 8 hr from the buccal mucosa were chosen. By using a swelling index analysis, the profiles and kinetics of in vitro drug release were examined. Results:The Terminalia chebula Retz. content in buccal tablets was determined to be 99.14±0.44%, and a DSC analysis showed that there was no chemical interaction between the ingredients of the tablet (8 g carbopol 934 and 20 g HPMC K15 made up the optimal formulation). After 8 hr of in vitro dissolving studies, a cumulative Terminalia chebula Retz. release of 90% was reached, which was confirmed by swelling analysis. Conclusion: The findings suggested that Terminalia chebula Retz's. optimised buccal tablets would be a promising and different delivery method for the treatment of asthma.

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Section: Discussionsupporting

confidence: 62%

Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma

PB Suruse,

MB Gawali,

RS Kalkotwar

et al. 2023

Ind. J. Pharm. Edu. Res

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“…To determine mucoadhesive strength, we applied a force (in grams) to a tablet pressed on a membrane. [22][23][24]…”

Section: Ph Studiesmentioning

confidence: 99%

Formulation Development of Mucoadhesive Tablets for Treatment of Hypertension using Losartan Potassium

Chavan,

Devineni,

Dev

et al. 2023

IJDDT

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Controlled-release losartan potassium incorporated bucccoadhesive tablets were prepared using guar gum and hydroxy propyl methylcellulose K4M (HPMC K4M). The polymers had demonstrated considerable influence for all reactions. Ethylcellulose, a naturally impermeable material, was employed as a backing layer. The direct compression approach was used to create nine distinct losartan potassium formulations. Drug and polymer compatibility was determined through preformulation research utilizing fourier transform infrared (FTIR) spectroscopy. Buccoadhesive tablets were evaluated by swelling, bioadhesive characteristics, pH and in-vitro drug dissolution. The bioadhesive strength of guar gum was found to be greater than that of HPMC K4M. The swelling effect provided by both polymers was adequate. All formulations were judged to have an adequate surface pH, with values falling between 7 and 5, suggesting no discomfort to the buccal cavity. Ex-vivo residence times ranging from 7.2 to >10 hours for all tablets tested demonstrated a high degree of adhesion. The improved formulation follows Fickian diffusion release process. The optimized formulation underwent a stability investigation in accordance with International Council for Harmonisation (ICH) criteria, and no significant changes were found.

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“…Other extracts from Neem plant, such as Neem gum collected from incised bark of Azadirachta indica trees, has an abundance of functional groups which make it efficient for drug delivery applications. Bioadhesive buccal tablets, made from Neem gum, containing nicorandil were studied for its potential to increase contact between drug and absorbing surface, to prevent first pass effect, lengthen half-life and ultimately reduce frequency of nicorandil administration during treatment of hypertension and angina pectoris ( 106 ). Neem gum has also been used to make hydrogel for drug delivery of anticancer drug methotrexate (MTX) under different pH conditions.…”

Section: Active Components Of Neem and Dose Formsmentioning

confidence: 99%

Exploring the therapeutic potential of Neem (Azadirachta Indica) for the treatment of prostate cancer: a literature review

et al. 2022

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Background and Objective: Multiple studies have demonstrated the medical potency of plant extracts and specific phytochemicals as therapeutics for prostate cancer (PCa) patients. Of note, the Neem plant known for its role as an antibiotic and anti-inflammatory is underexplored with an untapped potential for further development. This review focuses on extracts and phytochemicals derived from the Neem tree (Latin name; Azadirachta indica), commonly used throughout Southeast Asia for the prevention and treatment of a wide array of diseases including cancer. To date, there are more than 130 biologically active compounds that have been isolated from the Neem tree including azadirachtin, nimbolinin, nimbin, nimbidin, nimbidol, which have demonstrated a wide range of biological activities including anti-microbial, anti-fertility, antiinflammatory, anti-arthritic, hepatoprotective, anti-diabetic, anti-ulcer, and anti-cancer effects. Very few scientific reports focus on the benefits of Neem in PCa, even though this herb has been used to prevent the disease and its progression for years in complementary and alternative medicine.Methods: We used the search engines like PubMed, InCommon and Google using the key words: "Neem", "Cancer", "Prostate Cancer" and related words to find the information and data within the time frame from 1980-2022 for our article study.

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Development of Bioadhesive Buccal Tablets of Nicorandil Using a Factorial Approach

Cited by 6 publications

References 16 publications

Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma

Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma

Formulation Development of Mucoadhesive Tablets for Treatment of Hypertension using Losartan Potassium

Exploring the therapeutic potential of Neem (Azadirachta Indica) for the treatment of prostate cancer: a literature review

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