Development of bioadhesives from marine mussels

Abstract

Mussel adhesive proteins have received increased attention as potential biomedical and environmentally friendly underwater adhesives thanks to their fascinating properties, including strong and flexible adhesion, adhesion to various material substrates, water displacement, that they are harmless to human body, and controlled biodegradability. Several mussel adhesive proteins have been identified and characterized from mussels, and profound biochemical knowledge for mussel adhesions has been accumulated. In addition, a lot of effort has been put into realizing the promise of these bioadhesive materials from marine mussels. Here, progress in the diverse developmental approaches, with particular emphasis on functional production of mussel adhesive proteins, are reviewed.

Reinforced Multifunctionalized Nanofibrous Scaffolds Using Mussel Adhesive Proteins

“…[6] In addition, MAPs have strong adhesion ability, even on wet surfaces, as a result of unique amino acid arrangements and composition.…”

Sealants (Adhesives) to Prevent Bleeding

“…Mussel-derived adhesive protein is known to be the most powerful natural adhesive and has both fl exibility and elasticity [ 110,111 ] . In 1981, Waite and Tanzer discovered 3,4-dihydroxy-l -phenylalanine (DOPA) as a key component for the wet-resistant Fig.…”

“…More interestingly, it maintains its adhesion in wet environment and adheres to virtually any types of synthetic and natural surfaces [ 116 ] . However, expensive extraction, which requires 10,000 mussels to obtain 1 g of one type of adhesive proteins, and unsuccessful large-scale production limit its practical applications [ 110 ] .…”

Mussel adhesive protein fused with cell adhesion recognition motif triggers integrin‐mediated adhesion and signaling for enhanced cell spreading, proliferation, and survival

“…8,17,18 Marine mussels produce a mixture of adhesive proteins that function in the aqueous environment. [19][20][21] Mussel adhesive proteins (MAPs) form strong bonds with various surfaces, including glass and plastic. 20,22 Diverse applications of MAPs have been suggested, including cell and tissue adhesion.…”

“…[19][20][21] Mussel adhesive proteins (MAPs) form strong bonds with various surfaces, including glass and plastic. 20,22 Diverse applications of MAPs have been suggested, including cell and tissue adhesion. However, natural extraction is limited to the available amounts, and the practical production of recombinant MAPs is yet to be achieved.…”