Reinforced Multifunctionalized Nanofibrous Scaffolds Using Mussel Adhesive Proteins

Kim, Bum Jin; Choi, Yoo Seong; Cha, Hyung Joon

doi:10.1002/anie.201105789

Cited by 37 publications

(25 citation statements)

References 34 publications

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“…[17][18][19] Previously, we reported the successful fabrication of electrospun nanobers by blending the recombinant hybrid MAP fp-151 (rfp-151) with various types of synthetic polymers. 20 In particular, mixing rfp-151 with polycaprolactone (PCL) as a representative polymer model, which is an FDA-approved biodegradable polymer with proven biocompatibility, and has been used previously to fabricate electrospun 3-D nanoporous scaffolds employed in tissue engineering, 21 provided a 4-fold enhancement in the strength and stiffness compared to sole PCL nanobers. In the present study, we fabricated electrospun composite nanobers by using blends of PCL and a recombinant fp-1 (rfp-1), which was composed of 12 repeats of Mytilus fp-1 consensus decapeptides (AKPSYPPTYK), 18 and investigated whether the mechanical properties of the nano-bers are inuenced by the presence or absence of Fe(III) and DOPA complexes in DOPA-containing modied rfp-1 (mrfp-1) ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Mussel-inspired adhesive protein-based electrospun nanofibers reinforced by Fe(iii)–DOPA complexation

Kim

et al. 2015

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Mussel-inspired adhesive protein-based electrospun nanofibers reinforced by Fe(iii)–DOPA complexation

Kim

et al. 2015

J. Mater. Chem. B

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“…Optimized biological solutions provide a source of inspiration for scientists to design rationally and to construct reproducibly multiscale structures for multifunctional integration. [4][5][6][7][8] In nature, nacre, glass sponges, teeth, bones, and other biomaterials have evolved different solutions to overcome the brittleness of their building materials. [9][10][11] Among the variety of biological materials, nacre is one of most promising owing to its superior mechanical strength and toughness (Fig.…”

Section: Introductionmentioning

confidence: 99%

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

et al. 2013

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Multifunctional integration is an inherent characteristic for biological materials with multiscale structures. Learning from nature is an effective approach for scientists and engineers to construct multifunctional materials. In nature, mollusks (abalone), mussels, and the lotus have evolved different and optimized solutions to survive. Here, bio-inspired multifunctional graphene composite paper was fabricated in situ through the fusion of the different biological solutions from nacre (brick-and-mortar structure), mussel adhesive protein (adhesive property and reducing character), and the lotus leaf (self-cleaning effect). Owing to the special properties (self-polymerization, reduction, and adhesion), dopamine could be simultaneously used as a reducing agent for graphene oxide and as an adhesive, similar to the mortar in nacre, to crosslink the adjacent graphene. The resultant nacre-like graphene paper exhibited stable superhydrophobicity, self-cleaning, anticorrosion, and remarkable mechanical properties underwater. Multifunctional integration is an inherent characteristic for biological materials with multiscale structures.Learning from nature is an effective approach for scientists and engineers to construct multifunctional materials. In nature, mollusks (abalone), mussels, and the lotus have evolved different and optimized solutions to survive. Here, bio-inspired multifunctional graphene composite paper was fabricated in situ through the fusion of the different biological solutions from nacre (brick-and-mortar structure), mussel adhesive protein (adhesive property and reducing character), and the lotus leaf (self-cleaning effect).Owing to the special properties (self-polymerization, reduction, and adhesion), dopamine could be simultaneously used as a reducing agent for graphene oxide and as an adhesive, similar to the mortar in nacre, to crosslink the adjacent graphene. The resultant nacre-like graphene paper exhibited stable superhydrophobicity, self-cleaning, anti-corrosion, and remarkable mechanical properties underwater.

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“…Potential applications of electrospinning include filtration membranes [2,3], catalytic fibers [4], fiber-based biochips [5], sensors [6], wound healing [7,8], tissue engineering scaffolds [9,10] and drug delivery systems [11,12]. Recently, functionalized NFs have been developed by electrospinning polymers blended with nanoparticles [13,14], carbon nanotubes [15,16], ceramics [17] or biomolecules [18], or by surface modification with peptides [19] or proteins [20]. Furthermore, functional NFs with a core-shell structure have been prepared through coaxial electrospinning with the aim of realizing drug encapsulating fibers [21,22].…”

Section: Introductionmentioning

confidence: 99%

Temperature-responsive electrospun nanofibers for ‘on–off’ switchable release of dextran

Kim

Ebara

Aoyagi

2012

Science and Technology of Advanced Materials

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We propose a new type of 'smart' nanofiber (NF) with dynamically and reversibly tunable properties for the 'on-off' controlled release of the polysaccharide dextran. The fibers are produced by electrospinning copolymers of N-isopropylacrylamide (NIPAAm) and N-hydroxymethylacrylamide (HMAAm). The OH groups of HMAAm are subsequently crosslinked by thermal curing. The copolymers were successfully fabricated into a well-defined nanofibrous structure with a diameter of about 600-700 nm, and the fibers preserved their morphology even after thermal curing. The resulting crosslinked NFs showed rapid and reversible volume changes in aqueous media in response to cycles of temperature alternation. The fibrous morphology was maintained for the crosslinked NFs even after the cycles of temperature alternation, while non-crosslinked NFs collapsed and dispersed quickly in the aqueous solution. Dextran-containing NFs were prepared by electrospinning the copolymers blended with fluorescein isothiocyanate (FITC)-dextran, and the 'on-off' switchable release of FITC-dextran from the crosslinked NFs was observed. Almost all the FITC-dextran was released from the NFs after six heating cycles, whereas only a negligible amount of FITC-dextran was evolved during the cooling process. The reported incorporation of smart properties into NFs takes advantage of their extremely large surface area and porosity and is expected to provide a simple platform for on-off drug delivery.

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Reinforced Multifunctionalized Nanofibrous Scaffolds Using Mussel Adhesive Proteins

Cited by 37 publications

References 34 publications

Mussel-inspired adhesive protein-based electrospun nanofibers reinforced by Fe(iii)–DOPA complexation

Mussel-inspired adhesive protein-based electrospun nanofibers reinforced by Fe(iii)–DOPA complexation

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

Temperature-responsive electrospun nanofibers for ‘on–off’ switchable release of dextran

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