Development of biocompatible and safe polyethersulfone hemodialysis membrane incorporated with functionalized multi-walled carbon nanotubes

Abidin, Muhammad Nidzhom Zainol; Goh, Pei Sean; Ismail, Ahmad Fauzi; Othman, Mohd Hafiz Dzarfan; Hasbullah, Hasrinah; Said, Noresah; Kadir, Siti Hamimah Sheikh Abdul; Kamal, Fatmawati; Abdullah, Mohd Sohaimi; Ng, Be Cheer

doi:10.1016/j.msec.2017.03.273

Cited by 60 publications

(29 citation statements)

References 37 publications

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“…This was due to the enhanced surface hydrophilicity of the membranes as the result of the good dispersion of hydrophilic IONPs. The lowest BSA adsorption achieved was 3.3 μg/cm 2 by the M1:25 membrane; this was lower compared to those (5.0 and 4.5 μg/cm 2 ) found in previous studies by Abidin et al . The improved dispersion of the IONPs ensured a uniform hydrophilic surface of the membrane and, hence, minimized protein adsorption.…”

Section: Resultscontrasting

confidence: 65%

“…The nanoparticles drew air moisture rapidly as the external coagulant along the residence time. With respect to the reduced pore size for the M1:25 membrane, the highly viscous dope solution usually suppressed the pore formation, even though the outer surface usually experienced delayed phase separation …”

Section: Resultsmentioning

confidence: 99%

“…The trend implied that R increased as the amount of CA increased because of the improvement in the membrane hydrophilicity. Having a uniform hydrophilic surface weakens the tendency of the hydrophobic BSA to approach the membrane surface . The membrane with an IONP/CA weight ratio of 1:20 achieved the highest R of 98.5%.…”

Section: Resultsmentioning

confidence: 99%

“…A contact angle goniometer from Krüss Gambult (Germany) was used to determine the membrane surface hydrophilicity. The membrane porosity and average pore size were measured with a dry–wet weight method and filtration velocity method, respectively, as described by Abidin et al …”

Section: Methodsmentioning

confidence: 99%

“…Meanwhile, ultrafiltration membranes, which are pressure‐driven membranes, become the best option because they require very minimal transmembrane pressure (TMP) to separate molecules through physical sieving on the basis of size exclusion. Their relatively higher flux and rejection rate at low pressure make the whole separation process more effective, energy conserving, and therefore, cost effective . Ultrafiltration membranes have been widely applied to water and wastewater treatment from different sources, that is, surface and ground water, where contaminants, including natural organic matter or even bacteria and most viruses, can also be removed …”

Section: Introductionmentioning

confidence: 99%

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Facile modification of polysulfone hollow‐fiber membranes via the incorporation of well‐dispersed iron oxide nanoparticles for protein purification

Said

Hasbullah

Abidin

et al. 2019

J of Applied Polymer Sci

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Protein existence in wastewater is an important issue in wastewater management because proteins are generally present as contaminants and foulants. Hence, in this study, we focused on designing a polysulfone (PSf) hollow-fiber membrane embedded with hydrophilic iron oxide nanoparticles (IONPs) for protein purification by means of ultrafiltration. Before membrane fabrication, the dispersion stability of the IONPs was enhanced by the addition of a stabilizer, namely, citric acid (CA). Next, PSf-IONP-CA nanocomposite hollow-fiber membranes were prepared via a dry-wet spinning process and then characterized in terms of their hydrophilicity and morphology. Ultrafiltration and adsorption experiments were then conducted with bovine serum albumin as a model protein. The results that an IONP/CA weight ratio of 1:20 contributed to the most stable IONP dispersion. It was also revealed that the membrane incorporated with IONP-CA at a weight ratio of 1:20 exhibited the highest pure water permeability (58.6 L m −2 h −1 bar −1 ) and protein rejection (98.5%) while maintaining a low protein adsorption (3.3 μg/cm 2 ). The addition of well-dispersed IONPs enhanced the separation features of the PSf hollow-fiber membrane for protein purification.

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Section: Resultscontrasting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Facile modification of polysulfone hollow‐fiber membranes via the incorporation of well‐dispersed iron oxide nanoparticles for protein purification

Said

Hasbullah

Abidin

et al. 2019

J of Applied Polymer Sci

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Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

Said

Abidin

Hasbullah

et al. 2019

J of Applied Polymer Sci

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Middle molecule uremic toxins constitute to a quarter of uremic toxins present in human blood. In a condition where these uremic toxins accumulate in bloodstream due to renal failure, blood purification process using a high performance membrane is required. Here, we develop biocompatible mixed matrix membranes (MMMs) made up of polysulfone (PSf) and iron oxide nanoparticles (Fe2O3 NPs) with the focus to remove middle molecule uremic toxin effectively. The MMMs were evaluated in terms of their biocompatibility and separation performance. At higher Fe2O3 NPs loading, the MMM displayed a huge reduction of protein adsorption and platelet adhesion while maintaining normal blood coagulation time and acceptable complement activation. The optimized MMM exhibited high permeability (110.47 L m−2 h−1 bar−1), protein retention (99.9%) and demonstrated excellent clearance of urea (82%) and lysozyme (46.7%). The PSf/Fe2O3 MMM is proven to have promising attributes for hemodialysis application. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48234.

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Synthesis of ceramic tubular membrane from low‐cost clay precursors for blood purification application as substitute of commercial dialysis membrane

Roshni

Pugazhenthi

Periyasamy

et al. 2022

J of Chemical Tech & Biotech

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Background There has been a surge of interest in the preparation of membranes for clinical applications, chiefly for hemodialysis and hemofiltration. Despite numerous benefits, the exploitation of polymeric materials for dialysis membrane preparation remains unsatisfactory due to lack of proper physicochemical properties and biocompatibility. Therefore, this work focuses on the preparation of a ceramic membrane in a tubular configuration using an extrusion method and a clay material mixture. The biocompatibility of the membrane as well as its structural properties were studied. Results The porosity, permeability and pore size of the membrane were 39 ± 0.88%, 203 ± 0.51 L m−2 h−1 bar−1 and 304 ± 1.20 nm, respectively. The corrosion tolerance of the membrane was found to be better in acidic, alkaline and chlorine solutions. The protein adsorption, hemolysis and platelet adhesion were 2.1 ± 0.03 μg cm−2, 1.02 ± 0.01% and 6856 ± 84 platelets mm−2, respectively. The membrane demonstrated a prolonged blood coagulation time (PT = 18 ± 0.33 s and APTT = 70 ± 0.57 s), a 171 ± 0.57 s whole blood clotting time and complement activation of 805 ± 1.3 mg L−1 for C3 and 247.3 ± 0.98 mg L−1 for C4. During synthetic blood filtration, the membrane had sieving coefficients of 0.98 ± 0.005, 0.97 ± 0.008 and 0.93 ± 0.005 for creatinine, urea and phosphate, respectively. Finally, the membrane revealed a protein rejection of about 56 ± 0.57%. Conclusions The overall findings indicated that the prepared tubular membrane with excellent biocompatibility and uremic toxin removal can be used for hemofiltration application as an alternative to hemodialysis. © 2022 Society of Chemical Industry (SCI).

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Development of biocompatible and safe polyethersulfone hemodialysis membrane incorporated with functionalized multi-walled carbon nanotubes

Cited by 60 publications

References 37 publications

Facile modification of polysulfone hollow‐fiber membranes via the incorporation of well‐dispersed iron oxide nanoparticles for protein purification

Facile modification of polysulfone hollow‐fiber membranes via the incorporation of well‐dispersed iron oxide nanoparticles for protein purification

Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

Synthesis of ceramic tubular membrane from low‐cost clay precursors for blood purification application as substitute of commercial dialysis membrane

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