Development of biopolymers based interpenetrating polymeric network of capecitabine: A drug delivery vehicle to extend the release of the model drug

Targeted delivery of capecitabine to colon cancer cells using nano polymeric micelles based on beta cyclodextrin

“…For CAP the absorption band appeared were 3519 cm −1 and 3132 cm −1 (O–H stretching and N–H stretching respectively), at 2968 cm −1 shows the C–H stretching, at wave number 2859 cm −1 shows the presence of aldehyde group (CH O), at 1688.90 cm −1 (pyrimidine carbonyl stretching vibration), at 1606 cm −1 C C stretching, at 1500 cm −1 shows the N O bending vibrations and further at 1245 cm −1 shows the C–N bending vibrations, at 1041.60 cm −1 and 1206.49 cm −1 (C–F stretching and tetrahydrofuran ring respectively). 68,69 In the spectrum of the combination of CD + CP + CAP, the peaks at 1153 and 1029 cm −1 correspond to the C–O and C–O–C glucose units of CD, the peak at 1245 cm −1 is related to C–N bending vibrations, that at 1688.90 cm −1 to pyrimidine carbonyl stretching vibrations, that at 1606 cm −1 to the C C stretching of CAP, the peak at 1408 cm −1 is due to a combination of C–O stretching and the O–H in-plane deformation vibration of CP, where the index peaks of each component are clearly visible.…”

“…However, conventional oral dosage forms are ineffective in delivering drugs to the colon due to their absorption or degradation in the upper gastrointestinal tract. 5–8 Capecitabine (CAP), an oral prodrug of 5-fluorouracil (5-FU), is widely used in colorectal cancer, 9–13 and once it reaches the systemic circulation shows rapid absorption and converts into its active metabolite 5-FU via a tri-enzymatic step reaction. 14 Due to a short elimination half-life of 0.5–1 h and prescribed twice-daily dosing of 2.5 g m −2 , CAP causes severe adverse effects (cardiotoxicity, bone marrow depression, diarrhoea, nausea, vomiting, etc. )…”

Locust Bean Gum, a Vegetable Hydrocolloid with Industrial and Biopharmaceutical Applications

“…Locust bean gum and alginate form an interpenetrated complex, useful for drug delivery purposes because of their swelling behavior and drug release control [ 134 , 135 , 136 , 137 ]. The matrix is usually prepared by the ionotropic-gelation technique, using the coacervation of alginate with a divalent cation as Ca 2+ , which yields edible beads from natural raw materials.…”

“…The matrix is usually prepared by the ionotropic-gelation technique, using the coacervation of alginate with a divalent cation as Ca 2+ , which yields edible beads from natural raw materials. Aclofenac [ 135 , 137 ], capecitabine [ 134 ] and captopril [ 136 ] releases were analyzed in these types of systems. The drug delivery study showed a controlled release resulting from these matrices.…”

Scalable In-Fiber Manufacture of Functional Composite Particles

“…The application of magnetic–polymeric particles has revolutionized various fields, such as magnetic resonance imaging, drug delivery, chemical sensing, environmental remediation, optical sensing, and energy harvesting. , Future applications of composite particles are mainly driven by advancements in synthesis methodologies. Conventional chemical approaches have limited capabilities to tune the particle diameter and structure, and they must satisfy stringent limits over a set of experimental variables, such as concentration, dosage, and the nature of solvents and precursors, all of which must be controlled to attain the desired properties. − Additionally, chemical routes are hampered by unexpected coalescence and agglomeration during particle growth, and the obtained products are typically characterized by a broad particle size distribution.…”