Locust Bean Gum, a Vegetable Hydrocolloid with Industrial and Biopharmaceutical Applications

Petitjean, Max; Isasi, José Ramón

doi:10.3390/molecules27238265

Cited by 27 publications

(4 citation statements)

References 161 publications

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“…Importantly, this is the first report of developing a hydrogel patch from carrageenan, locust bean gum, KCl, and glycerin-containing CAE by using the design of the experiment approach. Carrageenan and locust bean gum biopolymers have been widely used in food, cosmetics, and pharmaceuticals ( 35 36 ). Furthermore, KCl as an enhancer of gel strength ( 37 ) and glycerin as a plasticizer made a flexible film for ease of administration ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Formulation design and physicochemical evaluation of an anti-inflammatory hydrogel patch containing Crinum asiaticum L. extract

Itharat¹,

Kongkwamcharoen²,

Ketjinda³

et al. 2023

Research in Pharmaceutical Sciences

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Background and purpose: Crinum asiaticum L. has long been used in Thai traditional medicine to treat osteoarthritis and inflammation by placing it on painful areas without further formulation design which is suboptimal for therapeutic use. Thus, this research aims to formulate a topical hydrogel patch containing C. asiaticum L. extracts (CAE) for anti-inflammatory effects. Experimental approach: The hydrogel patches are made from carrageenan, locust bean gum, with glycerin as a plasticizer and contain CAE formulated by using response surface methodology based on Box-Behnken design for design, determination of the effect of independent factors on the tensile strength, and optimization of the hydrogel patch formulation. In vitro release and skin permeation studies using a modified Franz diffusion cell and anti-inflammatory activity were evaluated. Findings/Results: The optimized CAE hydrogel patch showed a good correlation between predicted and observed tensile strength values and exerted its maximum cumulative lycorine release and permeation at 69.38 ± 2.78% and 48.51 ± 0.45%, respectively which were fit to Higuchi's kinetic model. The release rates were found to decrease with an increase in the polymer proportion of carrageenan and locust bean gum. In addition, the patch exerted potent in vitro anti-inflammatory activity with an IC 50 value of 21.36 ± 0.78 μg/mL. Conclusion and implication: The optimized CAE hydrogel patch application was successfully formulated with excellent mechanical properties, cumulative release, permeation, and anti-inflammatory effects. Thus, it has the potential to be further developed as a herbal application to relieve pain and inflammation. The in vivo anti-inflammatory effect of this delivery system should be further investigated.

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Section: Discussionmentioning

confidence: 99%

Formulation design and physicochemical evaluation of an anti-inflammatory hydrogel patch containing Crinum asiaticum L. extract

Itharat¹,

Kongkwamcharoen²,

Ketjinda³

et al. 2023

Research in Pharmaceutical Sciences

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“…This polysaccharide is used as a texturising agent in the food industry. Its solubility and rheological properties are mainly determined by the molecular conformation of the chains [ 137 ]. Locust bean gum has been co-formulated with κ-carrageenan to fabricate hard gel capsules [ 138 ].…”

Section: Wall Materials: Natural Polymer Coatingsmentioning

confidence: 99%

Encapsulation of Active Substances in Natural Polymer Coatings

Akpo,

Colin,

Perrin

et al. 2024

Materials

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Already used in the food, pharmaceutical, cosmetic, and agrochemical industries, encapsulation is a strategy used to protect active ingredients from external degradation factors and to control their release kinetics. Various encapsulation techniques have been studied, both to optimise the level of protection with respect to the nature of the aggressor and to favour a release mechanism between diffusion of the active compounds and degradation of the barrier material. Biopolymers are of particular interest as wall materials because of their biocompatibility, biodegradability, and non-toxicity. By forming a stable hydrogel around the drug, they provide a ‘smart’ barrier whose behaviour can change in response to environmental conditions. After a comprehensive description of the concept of encapsulation and the main technologies used to achieve encapsulation, including micro- and nano-gels, the mechanisms of controlled release of active compounds are presented. A panorama of natural polymers as wall materials is then presented, highlighting the main results associated with each polymer and attempting to identify the most cost-effective and suitable methods in terms of the encapsulated drug.

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“…[ 15,16 ] As a kind of nonionic hydrocolloid, LBG solution is not influenced by pH, salts, and heat. [ 17 ] However, the weak mechanical strength of LBG hydrogels is the major obstacle for their applications in tissue engineering. Various methods, such as combination with secondary polysaccharides, ions crosslinking, and construction of a double network, have been used to increase its mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinkable, Injectable Locust Bean Gum Hydrogel Induces Chondrogenic Differentiation of Stem Cells for Cartilage Regeneration

Luo

et al. 2023

Adv Healthcare Materials

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Due to the limited therapeutic efficacy of current treatments, articular cartilage regeneration is still challenging work. Scaffold-based tissue engineering provides a promising strategy for cartilage regeneration, but most scaffolds are limited by poor mechanical properties or unfavorable biocompatibility. Here, a novel photocrosslinkable, injectable locust bean gum (LBG)-methacrylate (MA) hydrogel is reported as a biomimetic extracellular matrix (ECM) for cartilage repair with minimal invasive operation. LBG-MA hydrogels show controllable degradation rate and improve mechanical properties and excellent biocompatibility. More importantly, LBG-MA hydrogel significantly induces bone mesenchymal stem cells to chondrogenic differentiation in vitro, as evidenced by high accumulation of cartilage-specific ECM components glycosaminoglycan and upregulated expression of key chondrogenic genes (collagen type II, aggrecan, and sex determining region Y-box9). Besides, the hydrogel is injectable, which can be in situ crosslinked via UV irradiation. Further, the photocrosslinkable hydrogels accelerate cartilage healing in vivo after 8 weeks of therapy. A strategy is provided here for photocrosslinkable, injectable, biodegradable scaffold fabrication based on native polysaccharide polymer for minimal invasive cartilage repair.

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Locust Bean Gum, a Vegetable Hydrocolloid with Industrial and Biopharmaceutical Applications

Cited by 27 publications

References 161 publications

Formulation design and physicochemical evaluation of an anti-inflammatory hydrogel patch containing Crinum asiaticum L. extract

Formulation design and physicochemical evaluation of an anti-inflammatory hydrogel patch containing Crinum asiaticum L. extract

Encapsulation of Active Substances in Natural Polymer Coatings

Photocrosslinkable, Injectable Locust Bean Gum Hydrogel Induces Chondrogenic Differentiation of Stem Cells for Cartilage Regeneration

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