Development of bronchus associated lymphoid tissue (BALT) in the rat, with special reference to T- and B-cells

Plesch, Benita; Gamelkoorn, Gerda J.; Ende, M van de

doi:10.1016/0145-305x(83)90066-6

Cited by 41 publications

(23 citation statements)

References 20 publications

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“…While it has been claimed that there are typical Tdependent areas in a parafollicular position lateral to the follicles [30] neither Plesch et al [16] nor ourselves [4] were able to confirm this even after neonatal thym ectomy in rabbits or rats. Some 18% of BALT cells carry a T-cell marker in the rabbit [29].…”

Section: Morphologymentioning

confidence: 85%

“…Gregson et al [15] showed that it appeared first in specific pathogen-free rats about the second week of life. Plesch et al [16] recorded the occurrence of BALT in fixed sites between the artery and bron chial epithelium suggesting a genetically predisposed site of development. Milne et al [17] showed that 18-day mouse embryo lungs transplanted subcutane ously in syngeneic animals developed primitive BALT follicles which possessed a lymphoepithelium.…”

Section: Ontogenymentioning

confidence: 99%

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Bronchus-Associated Lymphoid Tissue

Bienenstock¹

1985

Int Arch Allergy Immunol

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Section: Morphologymentioning

confidence: 85%

Section: Ontogenymentioning

confidence: 99%

Bronchus-Associated Lymphoid Tissue

Bienenstock¹

1985

Int Arch Allergy Immunol

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“…The present study confirmed that BALT did not develop in the prenatal period or in the first few weeks postnatally. The absence of BALT was also Fibrinous pneumonia 20 10 2-5 recorded in neonatal rabbits [2], rats [11], and pigs [10]. The appearance of the lymphoid aggregations in the bronchial lamina propria in the postnatal periods strongly suggests the necessity of antigenic stimuli.…”

Section: Discussionmentioning

confidence: 99%

Development of bronchus-associated lymphoid tissue in goats

Barman

Bhattacharyya

Upadhyaya

et al. 1996

Lung

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Development of bronchus-associated lymphoid tissue (BALT) was studied in clinically healthy and diseased Assam local goats. Animals were sacrificed before term as well as at different postnatal periods to screen lung sections for the presence of BALT. In a retrospective study sections prepared from pneumonic lungs were examined for any alteration of BALT. No BALT-like structure was found in neonatal goats. Bronchial lymphoid structures appeared in half of the animals from 1 month of age onward. The frequency of the BALT/4.5 cm2 of lung section ranged from one to two in 1-month-old and three to six in 1-year-old goats. In pneumonic lungs BALT became hyperplastic, and the size was also increased. The incidence of BALT was increased in lungs with fibrotic pneumonia. The number of BALT/section was high (five to eight/4.5-cm2 area) in mesenchymal cell proliferation. The present study shows that BALT did not develop in prenatal periods. But in the presence of potent antigens lymphoid aggregates appeared in the bronchial lamina propria of normal and diseased lungs.

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“…The epithelium overlying the BALT in unstim ulated rat has cilia and is hardly infiltrated with lymphocytes. Only after intratracheal stimulation the epithelium overlying BALT in the rat becomes infiltrated with lymphocytes, thus forming a lymphoepithelium [Plesch et al, 1983]. In BALT of adult rats, T and B cells occur; they oc cupy complementary areas [Plesch, 1982;Plesch et al, 1983] which are, however, not predetermined like in other lymphoid or gans [Parrott et al, 1966], These T-and B-cell areas thus show different localization from one BALT to another.…”

Section: Introductionmentioning

confidence: 98%

“…The morphology of bronchus-asso ciated lymphoid tissue (BALT) has been studied in several animals [Bienenslock et al, 1973a;Bienenslock and Johnston, 1976] including the rat [Chamberlain et al, 1973;Vaiet al, 1976;Fournier et al, 1977;Gregson et al, 1979a;Plesch, 1982;Plesch et al, 1983]. The BALT consists of a net-work of reticulum cells in which lympho cytes and macrophages are situated.…”

Section: Introductionmentioning

confidence: 99%

Histological Changes in Rat Bronchus-Associated Lymphoid Tissue after Administration of Five Different Antigens

Brugge-Gamelkoorn¹,

Plesch²,

Sminia³

et al. 1985

Respiration

Self Cite

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Histological changes in bronchus-associated lymphoid tissue (BALT) following single intratracheal administration of five different antigens were studied in the rat. After administration of T-dependent antigens (i.e., horseradish peroxidase, bovine serum albumin, and Bacillus Calmette Guérin) only minor changes in BALT in the rat occurred. Intratracheal administration of a T-independent antigen (lipopolysaccharide) and a partly T-independent antigen (paratyphoid vaccine) resulted after 1 week in an increase in cytoplasmic IgM-containing (clgM) blast cells and plasma cells; these appeared to enter via the high endothelial venules (HEV). After 6 weeks, germinal centers were seen.

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Development of bronchus associated lymphoid tissue (BALT) in the rat, with special reference to T- and B-cells

Cited by 41 publications

References 20 publications

Bronchus-Associated Lymphoid Tissue

Bronchus-Associated Lymphoid Tissue

Development of bronchus-associated lymphoid tissue in goats

Histological Changes in Rat Bronchus-Associated Lymphoid Tissue after Administration of Five Different Antigens

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