Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

Mali, Ashwin J.; Pawar, Atmaram; Purohit, Ravindra N.

doi:10.1155/2014/795371

Cited by 16 publications

(12 citation statements)

References 42 publications

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“…Design-Expert ® Software Version 9.0.4.1 Stat-Ease Inc., Minneapolis, USA, was used for the generation and evaluation of the statistical experimental design [22][23][24]. The 2 3 factorial design with three center points was used for the optimization of formulations of D-CS-loaded ALG-CHI nanoparticles.…”

Section: Optimization By Factorial Design Methodsmentioning

confidence: 99%

“…Shape and surface morphology of PNPs were done using scanning electron microscopy (SEM) [22,24]. For SEM analysis, the D-CS-loaded ALG-CHI nanoparticles were mounted directly on the Quanta 200 ESEM (FEI, USA) SEM aluminum stub, using double-sided sticking tape and scanned in a low vacuum chamber with a focused electron beam at 20 kV and magnification of 12,000X.…”

Section: Particle Morphological Studymentioning

confidence: 99%

“…Twin stage impinger is used to study the aerodynamic characteristics of aerosol generated from nanoparticulate suspension [24]. The suspension was made by dissolving 5 mg of freeze-dried D-CSloaded ALG-CHI nanoparticles in 2 ml of 0.9% sodium chloride.…”

Section: Particle Aerodynamic Studymentioning

confidence: 99%

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Formulation, Optimization, and Characterization of Biocompatible Inhalable D-Cycloserine-Loaded Alginate-Chitosan Nanoparticles for Pulmonary Drug Delivery

Shaji¹,

Shaikh²

2016

Asian J Pharm Clin Res

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ABSTRACT Objective: To prepare Nanoparticulate dosage form having improved drug bioavailability and reduced dosing frequency of antitubercular drugs which will helps in improving patient compliance in the treatment of multi-drug resistant tuberculosis (MDR-TB). Methods: Ionotropic gelation method was used to prepare D-cycloserine (D-CS)-loaded alginate-chitosan nanoparticles, and the particles are characterized by their particle size and morphology using particle size analyzer and scanning electron microscopy (SEM). X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier-transformed infrared (FTIR) studies were used to determine drug-polymer interactions and drug entrapment. Entrapment efficiency, drug loading (DL), particle size, and zeta potential of nanoparticles were also studied. The 2 factorial designs of experiments by Design-Expert ® V9 were used to optimize the particle size and entrapment efficiency of nanoparticles. Results: The optimized batch had shown the entrapment efficiency of 98.10±0.24% and DL of 69.32±0.44% with particle size and zeta potential as 344±5 nm and −42±11.40 mV, respectively. DSC, FTIR, and XRD studies confirmed the drug entrapment within nanoparticle matrix. SEM results showed spherical-shaped particles. Sustained release of drug from the nanoparticles was observed for 24 hrs period. Respirable fraction up to 52.37±0.7% demonstrates the formulation suitability for deep lung delivery. Lung inflammatory study showed a less inflammatory response. Conclusion: Ionotropic gelation method can be used to prepare biocompatible particles with a high entrapment efficiency, DL, optimum particle size, and controlled release characteristics, which can serve as a convenient delivery system for D-CS and could be a potential alternative to the existing conventional therapy in MDR-TB. Keywords: Nanoparticles, Alginate, Chitosan, Inhalation, Sustained release, Tuberculosis. 3

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Section: Optimization By Factorial Design Methodsmentioning

confidence: 99%

Section: Particle Morphological Studymentioning

confidence: 99%

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Formulation, Optimization, and Characterization of Biocompatible Inhalable D-Cycloserine-Loaded Alginate-Chitosan Nanoparticles for Pulmonary Drug Delivery

Shaji¹,

Shaikh²

2016

Asian J Pharm Clin Res

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“…This system is believed and accepted as a steady means to deliver the drugs to the target site with specificity [57]. Various delivery approaches involve microparticles, microspheres, solid lipid microparticles, polymeric microparticles [58, 99], surface coated microparticles [61], and so forth. In clinical practices, microparticles appreciably influence retention in the lungs and targeting properties of therapeutic agent, apart from the fact that active targeting microparticles also offer numerous advantages like masking, facilitation of handling, controlled dissolution profile, and protection [100].…”

Section: Novel Drug Delivery System For Dpimentioning

confidence: 99%

Dry Powder Inhalers: A Focus on Advancements in Novel Drug Delivery Systems

Mehta

2016

Journal of Drug Delivery

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Administration of drug molecules by inhalation route for treatment of respiratory diseases has the ability to deliver drugs, hormones, nucleic acids, steroids, proteins, and peptides, particularly to the site of action, improving the efficacy of the treatment and consequently lessening adverse effects of the treatment. Numerous inhalation delivery systems have been developed and studied to treat respiratory diseases such as asthma, COPD, and other pulmonary infections. The progress of disciplines such as biomaterials science, nanotechnology, particle engineering, molecular biology, and cell biology permits further improvement of the treatment capability. The present review analyzes modern therapeutic approaches of inhaled drugs with special emphasis on novel drug delivery system for treatment of various respiratory diseases.

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“…Dosage Unit Sampling Apparatus (DUSA) for desired testing device are used to perform Delivered Dose Uniformity test [45] . "Delivered dose uniformity" and "Delivered dose uniformity over the entire contents" are the content uniformity test specified by the Pharmacopoeias.…”

Section: Delivered Dose Uniformity Testmentioning

confidence: 99%

Current Development in the Evaluation Methods of Pulmonary Drug Delivery System

Shaji¹,

Shaikh²

2016

pharmaceutical-sciences

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Shaji and Shaikh: Current Development of Pulmonary Drug DeliveryThe pulmonary drug delivery system offers several merits over other drug delivery systems and therefore, this delivery route has been in prime focus for various applications like local and systemic therapeutics delivery. The overall development of drug delivery system depends on its efficacy, quality and safety and to achieve such attributes there is a need of reliable evaluation methods to test them. This review provides an in-depth analysis of the development in the evaluation of pulmonary drug delivery systems. In vitro methods of testing pulmonary products such as particle morphological studies, powder flow characteristics, moisture content test, aerosol turboelectric characterization, particles interparticulate forces measurement and solid state characterizations were discussed. Particle size and zeta potential measurement and evaluation of aerosol performance such as dose uniformity and aerodynamic particle size distribution were reviewed in detail. The development of dissolution methods for pulmonary products is also elaborated. Various cell culture methods for testing pulmonary products were overviewed. The in vivo testing methods including drug administration systems, drug deposition studies and pharmacokinetic studies and ex vivo testing models were also highlighted. Together an overview of current advancement in evaluation and characterization of pulmonary drug delivery system can be analyzed and studied through this review.

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Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

Cited by 16 publications

References 42 publications

Formulation, Optimization, and Characterization of Biocompatible Inhalable D-Cycloserine-Loaded Alginate-Chitosan Nanoparticles for Pulmonary Drug Delivery

Formulation, Optimization, and Characterization of Biocompatible Inhalable D-Cycloserine-Loaded Alginate-Chitosan Nanoparticles for Pulmonary Drug Delivery

Dry Powder Inhalers: A Focus on Advancements in Novel Drug Delivery Systems

Current Development in the Evaluation Methods of Pulmonary Drug Delivery System

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