Development of Carcinoma in the Aging Myelodysplastic Population

Gaskill, Sarah J.

doi:10.1159/000120564

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…More specifically, it has been reported that older patients with myelomeningocele may be at risk of developing both bladder and rectal carcinomas [25]. As these data show, patients with myelomeningocele are exposed to significant amounts of radiation.…”

Section: Carcinogenesismentioning

confidence: 90%

Radiation Exposure in the Myelomeningocele Population

Gaskill

Marlin²

1998

Pediatr Neurosurg

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Radiation-induced carcinoma is known to occur with lower doses of radiation exposure than previously recognized. The myelomeningocele population, because of its complex medical problems, is exposed to relatively high doses of radiation from diagnostic radiographs performed throughout their lives. To quantify the amount of exposure, we have calculated the total lifetime radiographic exposure for patients in a myelomeningocele clinic. Out of a myelomeningocele clinic of 248 patients, 112 were identified who had been followed in the clinic since birth. A retrospective history of radiographic exposure was obtained for each patient by reviewing the hospital X-ray jackets. Using standard radiographic dose tables, calculations of total radiation exposure were performed for each patient. The total skin dose exposure ranged from 3.96 to 171.29 rad with a mean of 42.99 rad (SD 33.58). The total skin dose per year of life ranged from 0.79 to 37.81 rad/year of life with a mean of 6.38 rad/year of life (SD 5.72). The total red marrow dose ranged from 0.3 to 29.04 rad with a mean of 7.02 rad (SD 6.24). The total red marrow dose per year of life ranged from 0.1 to 5.35 rad/year of life with a mean of 1.01 rad/year of life (SD 1.06). These data suggest that the radiation burden from diagnostic radiographs in the myelomeningocele population may ultimately contribute to carcinogenesis, mutagenesis and other radiation damage. Specific strategies for reducing the lifetime radiographic exposure in these patients are discussed in detail.

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Section: Carcinogenesismentioning

confidence: 90%

Radiation Exposure in the Myelomeningocele Population

Gaskill

Marlin²

1998

Pediatr Neurosurg

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“…Enterocystoplasties, and, more recently, gastrocystoplasty, are being perfarmed to improve bladder capacity and compliance, and further improve urinary continence (40). Numerous complications are associated with these procedures, including continuing incontinence, bladder perforation, infection, stone formation, metabolic abnormalities, mucus production (9,31), and the threat of malignant transformation (17). Prostatitis and epididymitis have presented as problems in the care of adolescent males with neurogenic urinary incontinence (9) for which prevention can be provided by an artificial sphincter placed above the prostate (24).…”

Section: Urinary Tract Managementmentioning

confidence: 99%