Development of catalyst-free carbon-sulfur bond formation reactions under aqueous media and their applications

Catalyst-Free Reactions under Biocompatible Conditions

“…In our efforts to develop a new bioconjugation technology that targets a specific native amino acid such as cysteine in the protein, we investigated the thiol-click reaction using an allenic amide as the electrophile. 19 In 2014, we reported an efficient and highly chemoselective C-S bond-forming reaction that uses an allenic amide as the electrophile (Scheme 3). 20 The reaction is highly selective, reacting selectively with cysteine moieties in unprotected peptides and proteins.…”

Ecofriendly Approach for the Large‐Scale Synthesis of 4‐Unsubstituted Coumarin‐3‐carboxylic Acids from o‐Hydroxy‐araldehydes with Meldrum's Acid in the Water‐SDS Micellar System

“…It possesses unique and unusual physical properties, such as high surface tension, high dielectric constant, high specific heat, large cohesive energy density, and also chemical properties, particularly its amphoteric nature and the ability to form hydrogen bonds. Thus water is the solvent of choice for chemical transformations not only from an environmental standpoint but also from an economic point of view [52–55] . Thus, the development of an efficient protocol for a useful organic transformation under ambient conditions using simply water as a solvent medium is one of the important aspects of green chemistry practice.…”

“…Thus water is the solvent of choice for chemical transformations not only from an environmental standpoint but also from an economic point of view. [52][53][54][55] Thus, the development of an efficient protocol for a useful organic transformation under ambient conditions using simply water as a solvent medium is one of the important aspects of green chemistry practice. During our ongoing research [56] to explore coumarin based novel materials for making memory devices and other switching behavior we are in need of multiple gram quantity of coumarin 3-carboxylic acids.…”

Glyoxylic Acid Monohydrate-Promoted Formation of the C–SO2 Bond Starting from Maleimides/Quinones and Sodium Sulfinates

“…or oxidant (Scheme a). In addition, photochemistry and electrochemical synthesis can also be used for the sulfonylation , (Scheme b,c). However, these methods still have some limitations such as the involvement of transition metals, limited substrate scope, and long reaction time.…”