Development of chemically cross-linked hydrophilic–hydrophobic hydrogels for drug delivery applications

Barron, Valerie; Killion, John A.; Pilkington, Laura; Burke, Gavin; Geever, Luke M.; Lyons, John G.; McCullagh, E.; Higginbotham, Clement L.

doi:10.1016/j.eurpolymj.2015.10.033

Cited by 15 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the past few decades variety of micro-and nano drug delivery systems (DDS) (i.e. capsules [1][2][3], particles [4,5], micelles [6][7][8], liposomes [9,10], hydrogels [11][12][13] or fibers [14]) are being intensively studied in order to improve therapeutic effectiveness of encapsulated drugs and substances for personalized drug therapy and regenerative medicine. However, the combination of an efficient encapsulation of small water-soluble substances by a relatively easy and fast method, it releasing during a long time together with a stimuli-responsive releasing of its defined quantity when it necessary remains a challenging task.…”

Section: Introductionmentioning

confidence: 99%

Free-standing microchamber arrays as a biodegradable drug depot system for implant coatings

Zykova

Kudryavtseva

Gai

et al. 2019

European Polymer Journal

View full text Add to dashboard Cite

 A free-standing PLLA microchamber arrays films are proposed to deliver small watersoluble substances.  Rhodamine B was completely released from PLLA microchambers in vitro within 13 days.  Low frequency ultrasound damages PLLA microchambers and detaches a sufficient number of microchamber "caps" with prolonged exposure time.  Free-standing printed PLLA microchamber arrays can be applied as endovascular stent cover for complementary pharmacological effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Free-standing microchamber arrays as a biodegradable drug depot system for implant coatings

Zykova

Kudryavtseva

Gai

et al. 2019

European Polymer Journal

View full text Add to dashboard Cite

show abstract

“…This property imparts injectability to in situ hydrogel system and makes it suitable for local and minimally invasive drug delivery, while hydrophobic drugs can be accommodated into the hydrophobic regions of the three-dimensional network of nanofiber structures of the hydrogels. Thus, hydrophobic drugs can be administered locally through drug-loaded in situ hydrogel system and then slowly released from in situ hydrogels into wanted tissues by degradation of the hydrogels [22].…”

Section: Introductionmentioning

confidence: 99%

The interaction between self – assembling peptides and emodin and the controlled release of emodin from in-situ hydrogel

Wei

Cui

Wang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Ion-complementary self-assembling peptides have potential in delivering hydrophobic drugs. This study involved two self-assembling peptides, RADA16-I and RVDV16-I, of which RVDV16-I was a novel selfassembling peptide with different hydrophobic side chains designed from RADA16-I. The purpose of this study was to observe the interaction between different self-assembling peptides and emodin through fluorescence spectrophotometry, CD, SEM and AFM; to construct a preliminary suspension in-situ hydrogel delivery system for emodin with the self-assembling peptides; and to investigate the drug-loading and drug-releasing properties of the self-assembling peptides on emodin. The results showed that both peptides can interact with emodin and the interaction was dominated by hydrophobic interaction. The aqueous solutions of both self-assembling peptides can form relatively stable suspensions with emodin under mechanical stirring, and the suspension can form in-situ hydrogel under physiological condition. In vitro release of emodin from the hydrogels showed a manner of sustained release to some extent. Cell viability studies showed inherent proliferation inhibiting effects of emodin on tumor cells was maintained or enhanced through the in-situ hydrogels. The self-assembling peptides RADA16-I and RVDV16-I had showed promising drug-loading and drug-releasing performance for hydrophobic drugs. It is reasonable to exploit self-assembling peptides as drug carriers for their great potential to improve delivery of hydrophobic drugs.

show abstract

Intelligent Hydrogels as Drug Delivery Systems

Novakovic

Matcham

Scott

2018

Gels Horizons: From Science to Smart Materials

View full text Add to dashboard Cite

Development of chemically cross-linked hydrophilic–hydrophobic hydrogels for drug delivery applications

Cited by 15 publications

References 26 publications

Free-standing microchamber arrays as a biodegradable drug depot system for implant coatings

Free-standing microchamber arrays as a biodegradable drug depot system for implant coatings

The interaction between self – assembling peptides and emodin and the controlled release of emodin from in-situ hydrogel

Intelligent Hydrogels as Drug Delivery Systems

Contact Info

Product

Resources

About