Development of chloramphenicol whey protein-based microparticles incorporated into thermoresponsive in situ hydrogels for improved wound healing treatment

Marzaman, Ardiyah Nurul Fitri; Sartini, Sartini; Mudjahid, Mukarram; Roska, Tri Puspita; Sam, Anwar; Permana, Andi Dian

doi:10.1016/j.ijpharm.2022.122323

Cited by 15 publications

(7 citation statements)

References 59 publications

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“…HPC is known to have a lower viscosity and slow hydration, and this is thought to be related to its adhesive ability [39] In contrast to HPMC, which in this study showed higher viscosity, resulting in higher bioadhesive strength. The number of hydrogen bonds formed is thought to affect the inherent properties of HPMC [40,41]. Furthermore, formula G4a, which did not contain bioadhesive polymers, still showed adhesion; this proves that poloxamer also has an adhesive effect as stated in previous studies [42],…”

Section: Bioadhesion Strength Studysupporting

confidence: 66%

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The Bioadhesive-Thermoresponsive Ophthalmic Gel Loaded Solid Dispersion of Triamcinolone Acetonide For Improvement of Ocular Inflammation Therapy

Stevani,

Rachmawaty,

Dewi

et al. 2023

Preprint

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Background: In developed countries, 10% of blindness cases are caused by uveitis (UV). Triamcinolone acetonide (TA) is a corticosteroid that has been widely used for the treatment of ocular inflammation both in intravitreal injection preparations or as an eye drop. The solubility of TA which is practically insoluble in water is an obstacle to its development. Objectives: This study aims to improve the therapeutic effectiveness of ocular inflammation by increasing the solubility of Triamcinolone acetonide (TA) as a hydrophobic drug. The enhancement of solubility allows for better bioavailability so it can optimize the therapy of UV. Methods: The solid dispersion method was selected to enhance the solubility of TA by comparing solvent-evaporation and freeze-drying methods. The solid dispersion method (SD-TA) was made with PEG 6000 and PVP-K30 as surfactants and then characterized by FTIR, XR diffraction, and SEM. Furthermore, SD-TA was mixed into the gel base and an ex vivo study was for ensure the local therapy. Result: The solvent-evaporation method produced more soluble TA than the freeze-drying method. F9 dissolved TA was ten times higher than pure TA (p<0.05). The G4c gel formula showed the ability to retain TA 3.15±0.15 mg at 24 h. Neither the G4c gel formula nor the SD-TA formula (F9) showed hemolysis activity. The gel also exhibits isotonic characteristics and did not cause any structural destruction of the RBCs. Conclusion: This study successfully demonstrated the morphological and structural changes of TA in SD-TA which proved to increase TA solubility and potentially provide local therapeutic effects by bioadhesive-thermoresponsive gel for better treatment of inflammation in the eye such as uveitis.

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Section: Bioadhesion Strength Studysupporting

confidence: 66%

“…Furthermore, another glass object was placed on top of the gel and given a load of 500 g and kept for 5 minutes. The diameter of the gel was measured as the spreadability of the gel [22,23] 2.9.6. Drug content analysis…”

Section: Spreadabilitymentioning

confidence: 99%

The Bioadhesive-Thermoresponsive Ophthalmic Gel Loaded Solid Dispersion of Triamcinolone Acetonide For Improvement of Ocular Inflammation Therapy

Stevani,

Rachmawaty,

Dewi

et al. 2023

Preprint

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“…The test tube was observed visually every 1°C temperature increase. The gelation temperature recorded was the temperature at which the gel did not move when the tube was inverted to 90° [24].…”

Section: Gelation Temperature Measurementmentioning

confidence: 99%

“…The pH of the thermosensitive gel was measured using a pH-meter at room temperature by inserting the tip of the electrode into the gel and the results were recorded after 2 minutes of observation [24].…”

Section: Ph Measurementmentioning

confidence: 99%

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Ex Vivo and In Vivo Retention Time Evaluation of Fucoidan Isolated from Macrocystis pyrifera Through a Thermosensitive Gel System in The Vaginal Route

Sam,

Marzaman,

Mudjahid

et al. 2024

BIO Web Conf.

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This study evaluated Fucoidan from Macrocystis pyrifera as a potential treatment for cervical cancer. The research aimed to examine Fucoidan’s in vivo retention capacities in poloxamer-based in situ gels for vaginal drug delivery systems. Five different thermosensitive gel formulations were developed, each with varying concentrations of Pluronic F127 and F68 polymers. The incorporation of HPMC affected the gelation temperature, viscosity, and bioadhesive strength. The accepted formula, F3, had a bioadhesive value of 5415.93 ± 98.74 dyne/cm2 and could form a gel at physiological temperature. Ex vivo animal models showed that Fucoidan components retained well on vaginal tissue. Only F1, F2, and F3 achieved the media after 8 hours of examination. In vivo evaluation showed F3 had the highest drug concentration retained in the vaginal mucosa of female rats after 8 hours (24,115 ± 4,842 g), slowly removed after 24 hours (13,014 ± 5,596 g). In conclusion, increases in the hydrophilic content of formulations led to the retained hydrogel formula, which increased drug release and lowered intravaginal elimination.

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Drug Delivery Systems

Azagury,

Kaeek,

Khoury

et al. 2023

Kirk-Othmer Encyclopedia of Chemical Technology

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Drug delivery systems (DDSs) and their administration routes play a critical role in the efficacy and safety of drugs. There are several physiological routes for drug delivery, including oral administration, injectables, inhalation, transdermal, intranasal, and transdermal delivery. This article focuses on these administration routes, describes their advantages and disadvantages, and elaborates on triggered and targeted DDS. Additionally, this article also describes drug release mechanisms from DDSs. DDSs are classified based on their physicochemical properties and administration routes. Pulsatile/stimuli systems allow controlled drug release at a specific time or location in response to an external stimulus. In addition, the controlled DDS employs several drug release mechanisms, such as diffusion, swelling, and erosion, to achieve the desired therapeutic effect. Representative applications of DDSs include the treatment of cancer, diabetes, and cardiovascular diseases. The COVID‐19 vaccine is a significant achievement in DDS, showcasing its potential to address global health crises. It utilizes lipid nanoparticles to encapsulate and protect mRNA, enabling targeted delivery to host cells. The mRNA instructs cells to produce the spike protein of the SARS‐CoV‐2 virus, triggering an immune response for COVID‐19 protection. In conclusion, DDSs and their administration routes are vital for safe and effective drug development, with recent advances such as pulsatile/stimuli systems showing promise for targeted delivery. The COVID‐19 vaccine development demonstrates the potential of DDS in tackling global health issues.

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Development of chloramphenicol whey protein-based microparticles incorporated into thermoresponsive in situ hydrogels for improved wound healing treatment

Cited by 15 publications

References 59 publications

The Bioadhesive-Thermoresponsive Ophthalmic Gel Loaded Solid Dispersion of Triamcinolone Acetonide For Improvement of Ocular Inflammation Therapy

The Bioadhesive-Thermoresponsive Ophthalmic Gel Loaded Solid Dispersion of Triamcinolone Acetonide For Improvement of Ocular Inflammation Therapy

Ex Vivo and In Vivo Retention Time Evaluation of Fucoidan Isolated from Macrocystis pyrifera Through a Thermosensitive Gel System in The Vaginal Route

Drug Delivery Systems

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