Development of cytidine 5′-monophosphate-protected gold-nanoclusters to be a direct luminescent substrate via aggregation-induced emission enhancement for ratiometric determination of alkaline phosphatase and inhibitor evaluation

Tumor Microenvironments-Adaptive Apoptotic Effects of Cytidine 5′-monophosphate-Capped Gold Nanoclusters

“…The TEM image of AuNCs@CMP revealed uniform distribution with an average particles size of 1.9 nm (Figure S1A). Besides, the FT-IR (Figure S1B) and 31 P NMR spectra (Figure S1C) revealed the binding sites of CMP to the metal core, and the phosphate group was outside, consistent with that reported.…”

“…The V max of 253.8 × 10 −8 M s −1 was achieved for it when using TMB as substrate, which encouraged us to explore other nanocatalysts protected by the nucleotide. Herein, the previously reported AuNCs@ CMP 31 show catalytic activity both in the absence and presence of H 2 O 2 , although it promotes the ROS generation only in H 2 O 2 . Finally, the AuNCs@CMP was applied to the tumor cells to activate the ROS generation, significantly promoting the antitumor cell effects.…”

“…The AuNCs@CMP were prepared through a reported method. 31 In brief, the solution containing 1.0 mM HAuCl 4 , 3.0 mM CMP, and 25.0 mM sodium citrate (pH = 4.5) was transferred to the autoclave and sealed. It was heated at 100 °C for 20 min.…”

The colorimetry and smartphone determination of perfluorooctane sulfonate based on cytidine 5′-monophosphate-capped gold nanoclusters with peroxidase-like activity

“…AuNCs@CMP was synthesized by a hydrothermal method reported in a previous study, 29 which can be summarized as: a solution with a final concentration of 1.0 mM HAuCl 4 , 25.0 mM sodium citrate ( pH = 4.5) and 3.0 mM CMP was transferred into a high-pressure reactor, which was then heated at 100 °C for 20 min. After cooling down to room temperature (RT, 20 °C), the AuNCs@CMP was washed with acetone, and the precipitate was then dried and lyophilized to obtain a solid powder.…”

“…27,28 Recently, we have reported a luminescent cytidine 5′-monophosphate-capped gold nanocluster (AuNCs@CMP). 29 Apart from its strong luminescence, its superior peroxidase-like activity was also revealed. 30 Assisted by H 2 O 2 , it significantly improved TMB oxidation and efficiently turned the solution from pale to blue.…”