Development of DNA Vaccines against Nocardia seriolae Infection in Fish

Kato, Go; Kato, Keitaro; Jirapongpairoj, Walissara; Kondo, Hidehiro; Hirono, Ikuo

doi:10.3147/jsfp.49.165

Cited by 23 publications

(11 citation statements)

References 33 publications

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“…DNA pAg85L‐based vaccine could protect amberjack when challenged with low dose of bacteria. However, in their study, the authors did not demonstrate an effective protection following high‐dose bacterial challenge (Kato et al., ).…”

Section: Immune Response and Vaccinementioning

confidence: 88%

“…Draft genome sequences of Nocardia seriolae Imajoh et al (2015Imajoh et al ( , 2016, Complete genome sequence of Nocardia seriolae Yasuike et al (2017) Diagnosis PCR amplification of the 16S rRNA gene region Laurent et al (1999) Loop-mediated isothermal amplification (LAMP) Itano et al (2006a), Xia, Zang, et al (2015) Immune response Transcriptome profiling of spleen in the infected fish Byadgi et al (2016) Vaccine BCG vaccine Kato et al (2012) DNA vaccines using Ag85-like gene of Nocardia seriolae Kato et al (2014) Administration of recombinant interferon c Nayak et al (2014) Administration of recombinant interleukin 12 and Formalin-killed bacteria Matsumoto et al (2017)…”

Section: Immune Response and Vaccinementioning

confidence: 99%

“…This study also suggested that both antigen‐specific and non‐specific (e.g., lysis of the bacteria by lysozymes) immune responses were induced by BCG vaccination. A previous study described the development of DNA vaccines using wild‐type and codon‐optimized Ag85‐like (Ag85L) gene of N. seriolae and examined their effects on nocardiosis in amberjack ( Seriola dumerili ) (Kato, Kato, Jirapongpairoj, Kondo, & Hirono, ). DNA pAg85L‐based vaccine could protect amberjack when challenged with low dose of bacteria.…”

Section: Immune Response and Vaccinementioning

confidence: 99%

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Current knowledge of nocardiosis in teleost fish

Maekawa

Yoshida

Wang

et al. 2018

Journal of Fish Diseases

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Nocardia sp. is the causative agent of nocardiosis, a lethal granulomatous disease of the skin, muscle, and various inner tissues affecting various teleost and shellfish. Four species of Nocardia have been isolated from diseased fish and shellfish, namely Nocardia asteroides, Nocardia seriolae, Nocardia salmonicida and Nocardia crassostreae. Therefore, in fish aquaculture, nocardiosis has caused severe economic losses, especially in the Asian region. Considerable research has been performed, since the first report of identified Nocardia sp. in fish, to characterize Nocardia sp. and identify rapid detection techniques, immune response against infection and prophylactic approaches. In this review, the current state of knowledge about nocardiosis in fish has been presented, including the pathogenesis, diagnosis, host immune response and vaccine development.

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Section: Immune Response and Vaccinementioning

confidence: 88%

Section: Immune Response and Vaccinementioning

confidence: 99%

Section: Immune Response and Vaccinementioning

confidence: 99%

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Current knowledge of nocardiosis in teleost fish

Maekawa

Yoshida

Wang

et al. 2018

Journal of Fish Diseases

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“…Oxytetracycline is effective in vitro ; however, its low bioavailability makes it inadequate for controlling the disease in Seriola spp, although coadministration with N‐acetyl‐d‐glucosamine (NAG) improved its absorption and efficacy (Akiyama et al, 2018). Today, there are no commercially available vaccines for N. seriolae but there are several attempts to develop one using various technologies ranging from inactivated bacterin, live‐attenuated (Itano et al, 2006), recombinant subunits (Ho et al, 2018) and DNA vaccines (Kato et al, 2014).…”

Section: Bacteriamentioning

confidence: 99%

Infectious diseases and treatment solutions of farmed greater amberjack Seriola dumerili with particular emphasis in Mediterranean region

Rigos

Katharios

Kogiannou

et al. 2020

Reviews in Aquaculture

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Greater amberjack (Seriola dumerili) is a very promising candidate for the diversification of the Mediterranean aquaculture due to its high demand, excellent flesh quality and high market prices. Its production expansion has, however, failed so far, due to several bottlenecks mainly related to pathology. This review addresses the major pathogens, which hinder the culture of greater amberjack with special focus in the Mediterranean region, and highlights possible treatment solutions. Among the important recorded pathogens of caged greater amberjack in the Mediterranean, the gill monogenean Zeuxapta seriolae seems to be the most problematic, causing significant losses. While formalin immersions are inefficient to combat this parasite, baths with hydrogen peroxide are extremely effective and praziquantel administration could be a more practical in-feed treatment solution. The digenean blood flukes, Paradeontacylix spp., also account for important losses in greater amberjack farms in the same region. Dietary administration of praziquantel constitutes an effective therapeutic measure against those infections. Vibrio harveyi is also a bacterial pathogen severely affecting fish maintained both in land-based facilities and in cages, whereas Epitheliocystis is a disease reported frequently that can be fatal when it occurs at early stages. Skin flukes such as Benedenia seriolae and Neobenedenia girellae as well as other parasites bacteria and viruses mentioned herein, which have caused substantial losses in Asian enterprises, but have not been identified yet in greater amberjack farmed in the Mediterranean, should be considered as potential threats.

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“…Recent studies have shown that DNA vaccines could be used to control viral pathogens; however, only a few have been tested against bacterial infections. Reportedly, DNA vaccines have been utilized in fish to control Streptococcus iniae [9], Vibrio anguillarum [10,11], Edwardsiella tarda [12][13][14], and Nocardia seriolae [15,16], indicating that DNA vaccines could be suitable for controlling bacterial diseases by provoking both non-specific and specific immune host responses. Despite the advantages of DNA vaccines, including low cost, safety, stability, and efficacy against bacterial and viral diseases, there are only two DNA vaccines licensed for use in commercial aquaculture.…”

Section: Introductionmentioning

confidence: 99%

Interleukin 34 Serves as a Novel Molecular Adjuvant against Nocardia Seriolae Infection in Largemouth Bass (Micropterus Salmoides)

2020

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DNA vaccines have been widely employed in controlling viral and bacterial infections in mammals and teleost fish. Co-injection of molecular adjuvants, including chemokines, cytokines, and immune co-stimulatory molecules, is one of the potential strategies used to improve DNA vaccine efficacy. In mammals and teleost fish, interleukin-34 (IL-34) had been described as a multifunctional cytokine and its immunological role had been confirmed; however, the adjuvant capacity of IL-34 remains to be elucidated. In this study, IL-34 was identified in largemouth bass. A recombinant plasmid of IL-34 (pcIL-34) was constructed and co-administered with a DNA vaccine encoding hypoxic response protein 1 (Hrp1; pcHrp1) to evaluate the adjuvant capacity of pcIL-34 against Nocardia seriolae infection. Our results indicated that pcIL-34 co-injected with pcHrp1 not only triggered innate immunity and a specific antibody response, but also enhanced the mRNA expression level of immune-related genes encoding for cytokines, chemokines, and humoral and cell-mediated immunity. Moreover, pcIL-34 enhanced the protection of pcHrp1 against N. seriolae challenge and conferred the relative percent survival of 82.14%. Collectively, IL-34 is a promising adjuvant in a DNA vaccine against nocardiosis in fish.

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Development of DNA Vaccines against Nocardia seriolae Infection in Fish

Cited by 23 publications

References 33 publications

Current knowledge of nocardiosis in teleost fish

Current knowledge of nocardiosis in teleost fish

Infectious diseases and treatment solutions of farmed greater amberjack Seriola dumerili with particular emphasis in Mediterranean region

Interleukin 34 Serves as a Novel Molecular Adjuvant against Nocardia Seriolae Infection in Largemouth Bass (Micropterus Salmoides)

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