Development of double-layered alginate-chitosan hydrogels for human stem cell microencapsulation

Nurhayati, Retno Wahyu; Cahyo, Rafianto Dwi; Alawiyah, Kamila; Pratama, Gita; Agustina, Elizabeth; Antarianto, Radiana Dhewayani; Prijanti, Ani Retno; Mubarok, Wildan; Rahyussalim, Ahmad Jabir

doi:10.1063/1.5139324

Cited by 10 publications

(7 citation statements)

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“…Tissue engineering and bone regeneration, drug delivery, cancer diagnosis (CD44 interaction) [25] Cyanobacteria Wound healing [26] Composite scaffold for skin regeneration [27] Alginate Wound dressing containing Alhagi maurorum extract [28] Wound dressing, scaffold for drug delivery [29] Hydrogels for wound dressing [23] Pseudomonas aeruginosa Alginate-chitosan hydrogels for human cell encapsulation [30] Azotobacter vinelandii Alginate-based hydrogel for inducing retinal pigment epithelium regeneration [31] Nostoc sp. Aerogel for drug delivery and tissue engineering [25] Pseudomonas, Azotobacter…”

Section: Bifidobacteriummentioning

confidence: 99%

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Biomedical Applications of Bacterial Exopolysaccharides: A Review

et al. 2021

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Bacterial exopolysaccharides (EPSs) are an essential group of compounds secreted by bacteria. These versatile EPSs are utilized individually or in combination with different materials for a broad range of biomedical field functions. The various applications can be explained by the vast number of derivatives with useful properties that can be controlled. This review offers insight on the current research trend of nine commonly used EPSs, their biosynthesis pathways, their characteristics, and the biomedical applications of these relevant bioproducts.

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Section: Bifidobacteriummentioning

confidence: 99%

“…Alginate is a well-known hydrogel material extracted from bacterial or brown algae cell walls. Alginate–chitosan hydrogels’ feasibility for human stem cell encapsulation has been reported [ 30 ]. A study reported ALG-based hydrogel’s potency for inducing retinal pigment epithelium (RPE) regeneration [ 31 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical Applications of Bacterial Exopolysaccharides: A Review

et al. 2021

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“…154 Chitosan is commonly used to encapsulate HSCs together with sodium alginate or collagen. 133,155…”

Section: Microscale Technologiesmentioning

confidence: 99%

“…154 Chitosan is commonly used to encapsulate HSCs together with sodium alginate or collagen. 133,155 In addition, pores can be created by generating gas inside supporting materials under high pressure or by foaming agents. 50 For instance, Keskar et al used the gas forming method to construct a poly(ethylene glycol) diacrylate (PEG-DA) porous scaffold using sodium bicarbonate as a foaming agent to simulate the bone marrow niche.…”

Section: Microporous Structurementioning

confidence: 99%

Engineering strategies to achieve efficientin vitroexpansion of haematopoietic stem cells: development and improvement

Liu

Tao

et al. 2022

J. Mater. Chem. B

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“…It is a linear polymer composed of different proportions of β‐(1 → 4)‐linked β‐mannuronic acid and α‐(1 → 4)‐linked l ‐guluronic acid 12 . Multivalent metal ions such as Ca 2+ , Ba 2+ , Zn 2+ , and Fe 2+ can cross‐link alginates to form gels 13 . There are many advantages of using SALG in drug delivery applications, such as its superior biocompatibility, bioadhesiveness, inertness, biodegradability, and high resemblance to the extracellular matrix 14 .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of pH‐sensitive double cross‐linked sodium alginate/chitosan hydrogels for controlled release of amoxicillin

Feyissa

Gupta

Edossa

et al. 2023

Polymer Engineering & Sci

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This research aims to fabricate a potent pH‐sensitive double network sodium alginate/chitosan hydrogel cross‐linked by calcium chloride (CaCl2) and glutaraldehyde for the controlled release of amoxicillin (AMX) to mitigate gastrointestinal tract bacterial infection. The effect of polymer ratios and CaCl2 concentration is investigated by the developing porosity, gel fraction, and swelling ratios in simulated physiological fluids of different pH and in vitro biodegradation at pH 7.4. Interaction between the polymers with the formation of cross‐linked structures, amorphous phase nature, good thermal stability, and transition from porous, fibrous structures to highly densified structures of the hydrogels is revealed by scanning electron microscopy, Fourier‐transform infrared spectroscopy, x‐ray diffraction, and thermogravimetric analysis. Based on structure–property relationships, a sodium alginate/chitosan hydrogel (weight ratio 75:25) cross‐linked with 2% CaCl2 and soaked in 2% (25 wt/v% solutions) glutaraldehyde is chosen for the incorporation of 200 mg of the drug. The percent cumulative AMX release in physiological fluids and the drug release kinetics using different models reveal that the most appropriate Korsmeyer–Peppas model suggests AMX release from the matrix follows diffusion coupled with swelling‐regulated time‐dependent non‐Fickian transport process related to hydrogel erosion. Excellent antibacterial against Streptococcus pyogenes and Escherichia coli is exhibited by this composition.

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Development of double-layered alginate-chitosan hydrogels for human stem cell microencapsulation

Cited by 10 publications

References 10 publications

Biomedical Applications of Bacterial Exopolysaccharides: A Review

Biomedical Applications of Bacterial Exopolysaccharides: A Review

Engineering strategies to achieve efficientin vitroexpansion of haematopoietic stem cells: development and improvement

Fabrication of pH‐sensitive double cross‐linked sodium alginate/chitosan hydrogels for controlled release of amoxicillin

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