2020
DOI: 10.1016/j.msec.2019.110257
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Development of double porous poly (ε - caprolactone)/chitosan polymer as tissue engineering scaffold

Abstract: observed by SEM and the physico-chemical properties of the blends were characterized by ATR-FTIR mapping, XRD and DSC. In addition, enzymatic degradation study was performed by using lipase (from Pseudomonas cepacia; 7U/ml) at 37°C in phosphate buffer saline (PBS) at physiological pH. Change in morphological properties and weight loss (%) were monitored at predetermined time intervals of the degradation study. To test the biocompatibility and potentialities of the membranes as a small diameter vascular graft f… Show more

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Cited by 20 publications
(16 citation statements)
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“…This behavior may have been influenced by viscoelasticity, the degree of entanglement of the chains in solution, and the solvent molecules’ size [ 49 ]. An acidic solvent can decrease the PCL polymeric chain by breaking of ester linkages, affecting the viscosity of solution and morphology on the surface [ 50 ]. Considering its potential to inhibit bacteria colonization, such as Escherichia coli and Staphylococcus aureus [ 45 ], the acetic acid was selected as the optimum solvent system to obtain PCL hybrids films (PCL/AO).…”
Section: Resultsmentioning
confidence: 99%
“…This behavior may have been influenced by viscoelasticity, the degree of entanglement of the chains in solution, and the solvent molecules’ size [ 49 ]. An acidic solvent can decrease the PCL polymeric chain by breaking of ester linkages, affecting the viscosity of solution and morphology on the surface [ 50 ]. Considering its potential to inhibit bacteria colonization, such as Escherichia coli and Staphylococcus aureus [ 45 ], the acetic acid was selected as the optimum solvent system to obtain PCL hybrids films (PCL/AO).…”
Section: Resultsmentioning
confidence: 99%
“…[172] Also, chitin and chitosan-based film have been the favored candidates for fabricating polymeric scaffolds for tissue repair and regeneration, due to their high porosity and programmable biodegradation rate. [96,102,173,174] For instance, Zhao et al developed a 3D printed chitosan duct for soft-tissue restoration. [174] Chitin and chitosan can also be used for wound treatment because of their excellent adhesive, anti-bactericidal, and antifungal characteristics.…”
Section: Chitin and Chitosanmentioning
confidence: 99%
“…7. CHI undergoes thermal degradation at approximately 270°C before melting, while Loading [MathJax]/jax/output/CommonHTML/fonts/TeX/fontdata.js pure PCL undergoes thermal degradation at approximately 60°C; thus, the degradation process was monitored to determine the miscibility of the two polymers [41,42]. In this analysis, the CHI control lm showed no endothermic peak associated with the melting process.…”
Section: Differential Scanning Calorimetry (Dsc)mentioning
confidence: 99%