“…Since the Compton camera (CC) was first proposed for medical imaging (Todd et al , 1974), many researchers have studied its use for a wide range of medical applications, including 2D and 3D imaging of prompt gamma (PG) emission from a patient during proton radiotherapy as a means of providing in vivo verification of the delivered proton beam range (Frandes et al , 2010; Gillam et al , 2011; Golnik et al , 2016; Hueso-Gonzalez et al , 2016; Kim et al , 2013; Kormoll et al , 2011; Krimmer et al , 2015; Llosa et al , 2012; Lojacono et al , 2013; McCleskey et al , 2015; Munoz et al , 2017; Peterson et al , 2010; Polf et al , 2015; Richard et al , 2011; Robertson et al , 2011; Roellinghoff et al , 2014; Rohling et al , 2017; Seo et al , 2010; Solevi et al , 2016; Thirolf et al , 2016; Thirolf et al , 2014). In standard Compton imaging, information pertaining to the energy deposited by and spatial coordinates of gammas that interact at least twice in the stages of a CC is used to create the images.…”