Development of drug cross — Tolerance in patients treated chronically with atropine

Mózsik, Gy.; Jávor, T

doi:10.1016/0014-2999(69)90214-3

Cited by 12 publications

(15 citation statements)

References 9 publications

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“…The development of pharmaco logical denervation and of tolerance to parasympatholytics was proved in patients observed 2-4 weeks after treatment with atro pine [4,12,14]. These patients with the above-mentioned phenom ena are designated patients denervated pharmacologically.…”

Section: Resultsmentioning

confidence: 99%

“…Thereafter parotid secretory responses were considered a suitable and objective meas ure of clinical pharmacological effects, of the pharmacodynamic actions of various parasympatholytics [4,5,6,10,12,14] and of excitatory and inhibitory processes within the nervous system [3].…”

Section: Discussionmentioning

confidence: 99%

“…In the present article effects of unconditioned nervous stimuli and of inhibition of such stimuli on the parotid secretory re sponses have been investigated in patients denervated pharmaco logically [12,14]. Central and peripheral excitatory and inhibitory nervous processes have been analyzed in these patients.…”

mentioning

confidence: 99%

“…This tolerance was re versed 3 to 6 days after cessation of atropine administration. De velopment of pharmacological denervation has previously been described during the period of tolerance to parasympatholytics [12,13,14].…”

mentioning

confidence: 99%

“…Development of tolerance to atropine [4] and to Gastrixone (8-methyltropmium-bromide-xanlhene-9-carboxylate -a quater nary parasympatholytic drug) [14] has previously been proved in patients chronically treated with atropine. This tolerance was re versed 3 to 6 days after cessation of atropine administration.…”

mentioning

confidence: 99%

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Central and Peripheral Excitatory and Inhibitory Nervous Processes in Patients Denervated Pharmacologically

Mózsik¹,

Lipák²

1970

Pharmacology

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Central and Peripheral Excitatory and Inhibitory Nervous Processes in Patients Denervated Pharmacologically

Mózsik¹,

Lipák²

1970

Pharmacology

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Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Mózsik

2014

Capsaicin as a Therapeutic Molecule

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Background: Capsaicin is a specific compound acting on capsaicin-sensitive afferent nerves. Aim: Capsaicin was used to study the different events of human gastrointestinal physiology, pathology, and clinical pharmacology, and possible therapeutic approaches to enhance gastrointestinal mucosal defense in healthy human subjects and in patients with various different gastrointestinal disorders as well as its use with nonsteroidal anti-inflammatory drugs (NSAIDs) in healthy subjects and in patients. Materials and Methods: The observations were carried out in 198 healthy human subjects and in 178 patients with different gastrointestinal (GI) diseases (gastritis, erosions, ulcer, polyps, cancer, inflammatory bowel diseases, colorectal polyps, cancers), and in 69 patients with chronic (Helicobacter pylori positive and negative) gastritis (before and after eradication treatment). The gastric secretory responses and their chemical composition, gastric emptying, sugar loading test, gastric transmucosal potential difference (GTPD) with application of capsaicin alone, after ethanol alone and with capsaicin, indomethacin-induced gastric mucosal microbleeding without and with capsaicin were studied. The immunohistochemical examinations of the capsaicin receptor (TRVP1), calcitonin gene-related peptide (CGRP), and substance P (SP) were carried out in gastrointestinal tract, and especially in patients with chronic gastritis (with and without Helicobacter infection, before and after classical eradication treatment). Classical molecular pharmacological methods were applied to study the drugs inhibiting the gastric basal acid output. Results: Capsaicin decreased the gastric basal output, enhanced the "non-parietal" (buffering) component of gastric secretory responses, and gastric emptying, and the release of glucagon. Capsaicin

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Capsaicin research as a new tool to approach of the human gastrointestinal physiology, pathology and pharmacology

2007

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Development of drug cross — Tolerance in patients treated chronically with atropine

Cited by 12 publications

References 9 publications

Central and Peripheral Excitatory and Inhibitory Nervous Processes in Patients Denervated Pharmacologically

Central and Peripheral Excitatory and Inhibitory Nervous Processes in Patients Denervated Pharmacologically

Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Capsaicin research as a new tool to approach of the human gastrointestinal physiology, pathology and pharmacology

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