Development of Drugs for Treatment of Mortellaro’s Disease in Cattle

Abstract

The root cause of premature culling of animals from the herd as a result of diseases and injuries is a lesion of distal portions of limbs of an infectious etiology, which include Mortellaro's disease. Mortellaro's disease affects up to 60 percent of the cattle in Russia. BelNano was developed, consisting of liposomal fractions and nanoparticles of silver and copper distributed in its volume. The surface of the nanoparticles has been specially modified to provide high efficiency on the skin and keratinized tissues. Pathogens that were found in impression smear and Fusobacterium necrophorum, Treponema, Borellia grown on nutrient media, which were sensitive to the active components of the BelNANO, ensuring their inactivation by action on the cell wall were revealed in the studied animals with Motellaro's disease. In experiments on the study of effectiveness of the BelNANO for the prevention and treatment of skin and skin coverings of the distal portion of limbs in Mortellaro's disease, 89 percent therapeutic efficacy was established, providing not only a high bactericidal and bacteriostatic effect on infectious agents, but also high regenerative properties of the drug, expressed in epithelization and the appearance of granulation tissue. Keywords-skin and skin lesions, Mortellaro's disease, Cu and Ag nanoparticles, lameness, drug for the treatment of interdigital cleft, cattle I.

In Vitro Studies of Nanoparticles as a Potentially New Antimicrobial Agent for the Prevention and Treatment of Lameness and Digital Dermatitis in Cattle

“…Despite this, the antimicrobial activity against G+ and G- bacteria in Lange et al’s study and our study was similar. Research by Belyakova et al [ 45 ] indicated that CuNPs and AgNPs had antibacterial activity against Fusobacterium necrophorum , Treponema spp., and Borrelia spp. bacteria, which are etiological factors that lead to lameness.…”