Development of dry powder inhalation system of novel vasoactive intestinal peptide (VIP) analogue for pulmonary administration

Ohmori, Yuki; Onoue, Satomi; Endo, Kazuhira; Matsumoto, Asako; Uchida, Shinya; Yamada, Shizuo

doi:10.1016/j.lfs.2005.12.049

Cited by 18 publications

(6 citation statements)

References 32 publications

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“…The intratracheally injected volume of these agents was 1.0 ml/kg body weight. The drug diffusion after the intratracheal administration was confirmed by the complete abolishment of the airway muscle contractile response induced by the intravenous injection of acetylcholine after the tiotropium administration (data not shown) and also by significant occupancy of vasoactive intestinal peptide (VIP) receptors in the anterior and posterior lobe of lungs after the intratracheal administration of the analogues (23). The control animals received vehicle alone.…”

Section: Intratracheal Administration Of Tiotropium Ipratropium and mentioning

confidence: 89%

“…Rats were fasted for 16 h and then intratracheally (by using 1 ml syringe) administered tiotropium (0.6 -6.4 nmol/kg), ipratropium (7.3 nmol/kg), and glycopyrrolate (7.5 nmol/kg) dissolved in saline under temporary anesthesia with diethyl ether as described previously (23). The intratracheally injected volume of these agents was 1.0 ml/kg body weight.…”

Section: Intratracheal Administration Of Tiotropium Ipratropium and mentioning

confidence: 99%

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Comparative Characterization of Lung Muscarinic Receptor Binding After Intratracheal Administration of Tiotropium, Ipratropium, and Glycopyrrolate

et al. 2011

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Abstract.The aim of the current study was to characterize comparatively the binding of muscarinic receptor in the lung of rats intratracheally administered anticholinergic agents (tiotropium, ipratropium, glycopyrrolate) used clinically to treat chronic obstructive pulmonary disease (COPD) and asthma. Binding parameters of [N-methyl-3 H]scopolamine methyl chloride ([ 3 H]NMS) were determined in tissues (lung, bladder, submaxillary gland) of rats intratracheally administered tiotropium, ipratropium, and glycopyrrolate. The in vitro binding affinity of tiotropium for the receptors was 10 -11-fold higher than those of ipratropium and glycopyrrolate. Intratracheal administration of tiotropium (0.6 -6.4 nmol/kg) caused sustained (lasting at least 24 h) increase in the apparent dissociation constant (K d 3 H]NMS binding. The effect by ipratropium was observed at 2 h but not 12 h, and that by glycopyrrolate lasted for 24 h. Both agents had little influence on the muscarinic receptors in the bladder and submaxillary gland. The present study provides the first evidence that tiotropium, ipratropium, and glycopyrrolate administered intratracheally in rats selectively bound muscarinic receptors of the lung, and tiotropium and glycopyrrolate had a much longer-lasting effect than ipratropium.

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Section: Intratracheal Administration Of Tiotropium Ipratropium and mentioning

confidence: 89%

Section: Intratracheal Administration Of Tiotropium Ipratropium and mentioning

confidence: 99%

Comparative Characterization of Lung Muscarinic Receptor Binding After Intratracheal Administration of Tiotropium, Ipratropium, and Glycopyrrolate

et al. 2011

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“…Carbohydrate lyoprotectants act by protecting membrane integrity and preventing payload leakage due to their high T g (Chen et al, 2010). Previously, lyophilization technique has been successfully employed for insulin and VIP-containing liposomes, but freeze-drying of salmon calcitonin (sCT) liposomes has not been reported to date (Bi et al, 2008;Ohmori et al, 2006). Therefore, this work aimed to determine the impact of lyophilization on the encapsulation efficiency of sCT in PEGylated and non-PEGylated liposomes.…”

Section: Introductionmentioning

confidence: 99%

Effect of lyophilization on liposomal encapsulation of salmon calcitonin

Swaminathan¹,

Ehrhardt²

2014

Journal of Liposome Research

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“…Also, VIP induces chloride secretion by epithelium cells of the bronchia and stimulates ciliary motility. However, VIP clinical application has limitation for a number of reasons, including its short plasma half-life after intravenous administration [4,5,10,11]. In this study, we used intra-trachea administration form of VIP and, therefore, there were no similar problems.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effect of N‐acetyl‐seryl‐aspartyl‐proline and vasoactive intestinal peptide on chronic obstructive pulmonary disease pathophysiology

Cai

Chen

Nasab

et al. 2022

Fundamemntal Clinical Pharma

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Chronic obstructive pulmonary disease (COPD) as an inflammatory respiratory system disease is caused by exposure to cigarette smoke and tobacco in long‐term. Some anti‐inflammatory peptides can control inflammation in COPD. N‐acetyl‐seryl‐aspartyl‐proline (Ac‐SDKP) and vasoactive intestinal peptide (VIP) as peptide have anti‐inflammatory effect, and, in this study, the effect of Ac‐SDKP and VIP on COPD inflammation was studied. After producing cigarette smoke‐induced COPD mice model, which were treated with VIP and Ac‐SDKP, the levels of antioxidant‐related factors (malondialdehyde (MDA) and superoxide dismutase (SOD)), fibrotic factors (hydroxyproline (HP) and TGF‐β), pro‐inflammatory cytokines (TNF‐α, IL‐1β, and IL‐6), and inflammation in histopathological examination were studied. MDA, Remodeling factors, pro‐inflammatory cytokines, and inflammation in lung tissue were controlled by VIP and Ac‐SDKP treatment. These treatments could enhance SOD. VIP and Ac‐SDKP as immuno‐regulatory factors had benefit effect in treatment of COPD. The anti‐inflammatory, anti‐fibrosis, and anti‐oxidant properties of VIP and Ac‐SDKP may be effective therapy in COPD.

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Development of dry powder inhalation system of novel vasoactive intestinal peptide (VIP) analogue for pulmonary administration

Cited by 18 publications

References 32 publications

Comparative Characterization of Lung Muscarinic Receptor Binding After Intratracheal Administration of Tiotropium, Ipratropium, and Glycopyrrolate

Comparative Characterization of Lung Muscarinic Receptor Binding After Intratracheal Administration of Tiotropium, Ipratropium, and Glycopyrrolate

Effect of lyophilization on liposomal encapsulation of salmon calcitonin

Immunomodulatory effect of N‐acetyl‐seryl‐aspartyl‐proline and vasoactive intestinal peptide on chronic obstructive pulmonary disease pathophysiology

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