1995
DOI: 10.1002/cne.903530303
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Development of ectopic projections from the ventral cochlear nucleus to the superior olivary complex induced by neonatal ablation of the contralateral cochlea

Abstract: The ability of an animal to localize a sound in space requires the precise innervation of the superior olivary complex by the ventral cochlear nuclei on each side of the lower brainstem. This precise pattern of innervation could require an immutable recognition of appropriate targets by afferent processes arising from these nuclei. This possibility was investigated by destroying one cochlea of gerbil pups (Meriones unguiculatus) on the second postnatal day and assessing the projections from the ventral cochlea… Show more

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Cited by 109 publications
(96 citation statements)
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“…Currently, the impact of unilateral, electrically-driven auditory development on the organization and function of the binaural auditory system is not well understood. Animal models have shown that early-induced unilateral deafness results in reorganization of projections from the CN to the SOC (Kitzes et al 1995;Shepherd and Hardie 2001) and cell death in the LSO of the inactivated side (Moore 1992). Kitzes et al (1995) have shown that unilateral auditory deprivation results in ectopic projections from the cochlear nucleus to the three main nuclei of the SOC (the medial and lateral nuclei and the medial nucleus of the trapezoid body).…”
Section: Sequentially Provided Bilateral Cochlear Implantsmentioning
confidence: 99%
See 1 more Smart Citation
“…Currently, the impact of unilateral, electrically-driven auditory development on the organization and function of the binaural auditory system is not well understood. Animal models have shown that early-induced unilateral deafness results in reorganization of projections from the CN to the SOC (Kitzes et al 1995;Shepherd and Hardie 2001) and cell death in the LSO of the inactivated side (Moore 1992). Kitzes et al (1995) have shown that unilateral auditory deprivation results in ectopic projections from the cochlear nucleus to the three main nuclei of the SOC (the medial and lateral nuclei and the medial nucleus of the trapezoid body).…”
Section: Sequentially Provided Bilateral Cochlear Implantsmentioning
confidence: 99%
“…Animal models have shown that early-induced unilateral deafness results in reorganization of projections from the CN to the SOC (Kitzes et al 1995;Shepherd and Hardie 2001) and cell death in the LSO of the inactivated side (Moore 1992). Kitzes et al (1995) have shown that unilateral auditory deprivation results in ectopic projections from the cochlear nucleus to the three main nuclei of the SOC (the medial and lateral nuclei and the medial nucleus of the trapezoid body). Unilateral auditory deprivation has also been shown to result in a decrease in the size and number of neurons in the LSO ipsilateral to the damaged cochlea but not in the contralateral LSO (Moore 1992).…”
Section: Sequentially Provided Bilateral Cochlear Implantsmentioning
confidence: 99%
“…On the other hand, the classic studies of Moore (1985) and Kitzes (1995Kitzes ( , 1996 demonstrated that neonatal ablation of one cochlea resulted in substantial reorganization of the central auditory projections, with the intact CN forming highly ectopic projections to the superior olivary nuclei and the medial nucleus of the trapezoid body and projections to the ipsilateral inferior colliculus more than doubling in size. Our current study provides a somewhat parallel experimental paradigm, in that animals were deafened as neonates, one ear remained deaf throughout life, and the other ear was activated by a cochlear implant beginning at 8 weeks of age and continuing into adulthood.…”
Section: Topography Of Auditory Nerve Projections To the Cochlear Nucmentioning
confidence: 99%
“…A corollary of this hypothesis is that when the selectivity of SG-to-CN projections is reduced due deafness occurring early in life, restoration of electrical activity in the auditory nerve via a cochlear implant may be effective in ameliorating or preventing these alterations. On the other hand, previous studies (Kitzes et al 1995;Kitzes 1996;Moore and Kitzes 1985;Moore and Kowalchuk 1988) have reported that neonatal removal of one cochlea results in substantial reorganization of the central auditory projections, with projections from the intact CN more than doubling in size in their distribution to the auditory midbrain and forming highly ectopic projections to the brainstem superior olivary complex and medial nucleus of the trapezoid body. Thus, an alternative hypothesis is that electrical stimulation of one cochlea after neonatal deafening might exacerbate the reduced selectivity of CN projections and elicit substantially greater expansion or reorganization of auditory nerve projections in the CN ipsilateral to the implant.…”
Section: Introductionmentioning
confidence: 95%
“…The classic studies of Moore and Kitzes (Kitzes et al 1995;Kitzes 1996;Moore and Kitzes 1985;Moore and Kowalchuck 1988) showed that adult animals studied after neonatal removal of one cochlea exhibited substantial reorganization of the central auditory projections, with projections from the intact CN more than doubling in size in their distributions to the ipsilateral IC and forming highly ectopic projections to the superior olivary nuclei and the medial nucleus of the trapezoid body. Our present study provides a parallel experimental paradigm in that animals were deafened as neonates: One ear remained deaf throughout life, but the other ear was strongly activated by electrical stimulation beginning at 7 weeks of age and continuing to adulthood.…”
Section: Auditory Nerve Projections After Chronic Electrical Stimulationmentioning
confidence: 99%