Development of effective anti-influenza drugs: congeners and conjugates – a review

Shie, Jiun‐Jie; Fang, Jim‐Min

doi:10.1186/s12929-019-0567-0

Cited by 90 publications

(80 citation statements)

References 139 publications

(146 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Influenza viruses (IVs) have been involved in pandemics and seasonal epidemics and are serious threats to humans [ 1 – 4 ]. IV pandemics have been noted in the past; for example, the Spanish flu caused by the H1N1 IV in 1918, the Asian flu caused by the H2N2 IV in 1957, the Hong Kong flu caused by the H3N2 IV in 1968, the bird flu caused by the H5N1 and H7N9 IVs in 2003 and 2013, respectively, and the swine flu caused by the H1N1 IV in 2009.…”

Section: Introductionmentioning

confidence: 99%

Redox control in the pathophysiology of influenza virus infection

et al. 2020

View full text Add to dashboard Cite

Triggered in response to external and internal ligands in cells and animals, redox homeostasis is transmitted via signal molecules involved in defense redox mechanisms through networks of cell proliferation, differentiation, intracellular detoxification, bacterial infection, and immune reactions. Cellular oxidation is not necessarily harmful per se, but its effects depend on the balance between the peroxidation and antioxidation cascades, which can vary according to the stimulus and serve to maintain oxygen homeostasis. The reactive oxygen species (ROS) that are generated during influenza virus (IV) infection have critical effects on both the virus and host cells. In this review, we outline the link between viral infection and redox control using IV infection as an example. We discuss the current state of knowledge on the molecular relationship between cellular oxidation mediated by ROS accumulation and the diversity of IV infection. We also summarize the potential anti-IV agents available currently that act by targeting redox biology/pathophysiology.

show abstract

Section: Introductionmentioning

confidence: 99%

Redox control in the pathophysiology of influenza virus infection

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Our results still supported previous observational studies that antiviral treatment of critically ill adult influenza patient with a NAI was associated with survival benefit. [23,24] However, problems such as delayed administration of NAIs (> 48 hours), drug resistance and induced cytokine storms still put severe cases at risk of early mortality [25,26].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analyses of immunoglobulin proteome and clinical variables identify biomarkers to predict mortality in patients with influenza-associated lower respiratory tract infection

Teng

Wang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Influenza-associated lower respiratory tract infection (I-LRTI) brings a heavy clinical burden, and clinicians lack an effective prognostic evaluation system to control disease progression. Methods: This was a prospective, observational study, and the endpoint was 28-day mortality. Plasma microarrays were used for quantitative analysis of immunoglobulin (Ig) and its subclasses. Prognostic factors from Ig and clinical variables in the patients with I-LRTI were identified to create a prediction model. Results: To address this issue, we prospectively and observationally studied the difference of immunoglobulin proteome and clinical variables between survivors and non-survivals in 107 patients with influenza-associated lower respiratory tract infection (I-LRTI) selected from four hospitals affiliated to Capital Medical University. The results identified 17 variables with significant or marginally statistical differences by univariate analysis, including lymphocyte count (LY), monocytes count (MO), CD3 + CD4 + T-cell count, CD3 + CD8 + T-cell count, IgA, IgA1, IgG2, IgG4, CRP, PCT, D-dimer, oxygenation index, glycosylated hemoglobin, lactic acid (LAC), base excess of blood, lactic dehydrogenase, and α-hydroxybutyrate dehydrogenase. Furthermore, we analyzed the correlations of all the variables by hierarchical clustering analysis in which different functional modules were formed between survival and non-survival groups that are associated with the immunity and severe infection. At last, we built a prediction model with nine variables (D-dimer, days from onset to ED, IgA, IgG2, LAC, LY, MO, Staphylococcus aureus co-infection and age), with which the AUC value of 0.810 (95% CI 0.755-0.839) was achieved with the evaluation of LOO cross validation. The predictive model was further validated by disease severity evaluation. Conclusion: Lethal bacterial (especially S. aureus ) co-infection was associated with cellular immunity, oxygenation index, HbA1C and age. The combined prediction model with D-dimer, Days from onset to ED, IgA, IgG2, LAC, LY, MO, S.aureus co-infection and age demonstrate the predictive mortality powerfully in patients with I-LRTI.

show abstract

“…The stage of attachment of the virion to the cell surface (receptor binding) and fusion with the cell membrane is mediated by hemagglutinin (HA), which interacts with the host cell glycoproteins containing terminal sialic acid ( N -acetylneuraminic acid, Neu5Ac) [ 46 , 47 ] ( Figure 6 ). Thus, hemagglutinin is a target for inactivating the influenza virus.…”

Section: Porphyrins and Their Analogues Structurementioning

confidence: 99%

The Application of Porphyrins and Their Analogues for Inactivation of Viruses

et al. 2020

View full text Add to dashboard Cite

The problem of treating viral infections is extremely relevant due to both the emergence of new viral diseases and to the low effectiveness of existing approaches to the treatment of known viral infections. This review focuses on the application of porphyrin, chlorin, and phthalocyanine series for combating viral infections by chemical and photochemical inactivation methods. The purpose of this review paper is to summarize the main approaches developed to date in the chemical and photodynamic inactivation of human and animal viruses using porphyrins and their analogues and to analyze and discuss the information on viral targets and antiviral activity of porphyrins, chlorins, of their conjugates with organic/inorganic compounds obtained in the last 10–15 years in order to identify the most promising areas.

show abstract

Development of effective anti-influenza drugs: congeners and conjugates – a review

Cited by 90 publications

References 139 publications

Redox control in the pathophysiology of influenza virus infection

Redox control in the pathophysiology of influenza virus infection

Comprehensive analyses of immunoglobulin proteome and clinical variables identify biomarkers to predict mortality in patients with influenza-associated lower respiratory tract infection

The Application of Porphyrins and Their Analogues for Inactivation of Viruses

Contact Info

Product

Resources

About