Development of Electrospun Shellac and Hydroxypropyl Cellulose Blended Nanofibers for Drug Carrier Application

Abstract

The aim of this study was to develop the electrospun shellac (SHL) and hydroxypropyl cellulose (HPC) blended nanofibers for drug carrier application. The effects of polymer solution and electrospinning parameters, including SHL-HPC ratio, HPC concentration, applied voltage and flow rate, on the appearance of fibers were investigated. Based on the results, electrospun fiber was not obtained when a solution of HPC alone was employed. However, the fibers would be obviously fabricated as SHL was added to the HPC solution. An increase in the SHL ratio in SHL-HPC blended solution could accordingly lead to a remarkable enhance in the fiber diameter. In addition, the continuous nanofibers with less beads were gradually formulated when the HPC concentration was increased. The electrospinning parameters seemed to be significant. The elevation of infusion rate from 0.5 to 1 mL/h would contribute to the preparation of thick fibers with the diameters enlarging from 666.9 to 843.5 nm. With the applied voltage increasing from 15 to 30 kV during the electrospinning process, the fabrication of small nanofibers with the diameters reducing from 843.5 to 741.6 nm would be conducted. In this study, monolaurin (ML), a broad antimicrobial agent, was encapsulated into the SHL-HPC carrier for the purpose of drug delivery application. Regarding the result, the loaded concentration of ML could not be enhanced by introducing HPC to the SHL fibers.

Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

“…However, the release of active compounds might well be altered regardless of the type of polymer used to fabricate electrospun fibers. Due to the mechanical properties, controlled degradation rate, and biological compatibility of shellac, a natural polymer derived from the excretions of the lac Kerria lacca insect, electrospun fibers seemed to become widely attractive [ 13 , 14 , 15 , 16 , 17 ]. Shellac resin contains derivatives of jalaric and laccijalaric acids ( Figure 2 ), and a detailed analysis of the compounds in shellac was recently revealed by flow injection and liquid chromatography coupled with electrospray ionization and mass spectrometry [ 18 ].…”

Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract

“…This finding suggests that an excess of electrostatic forces may cause the polymer flow to undergo overstretching, thereby producing fibers with larger diameters [62,63]. Although certain studies have reported no correlation between the voltage applied and the diameter of the fibers [64], it was discovered that increasing the voltage during the electrospinning process generated more charges, which improved the polymer solution's ability to stretch and contributed to the production of thinner nanofibers with a smaller diameter [65]. These results are consistent with those of other investigations [23,66,67] that have documented comparable results.…”

Advances in Natural Product Extraction Techniques, Electrospun Fiber Fabrication, and the Integration of Experimental Design: A Comprehensive Review

“…Because of the mechanical characteristics, controlled biodegradation, and biological compatibility of shellac, electrospun fibers made from shellac, a natural polymer derived from the insect Kerria lacca ’s secretion, appear to be gaining widespread popularity [ 126 , 127 , 128 , 129 , 130 , 131 , 132 ]. Consequently, this article explores the creation of bioactive shellac electrospun fibers.…”