Development of epilepsy in newborns with moderate hypoxic-ischemic encephalopathy and neonatal seizures

Pisani, Francesco; Orsini, Manuela; Braibanti, Silvia; Copioli, Cristiana; Sisti, Lisa; Turco, Emanuela Claudia

doi:10.1016/j.braindev.2008.04.001

Cited by 60 publications

(52 citation statements)

References 31 publications

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“…An incidence of neonatal-onset epilepsy of 26% (26/100 patients) was calculated from the six studies reporting this information, 2,11,18,21,22,32 From a total of 28 studies, 2,5,10,11,14e19,21e23,28e30, 32,33,35,36,38e42,45,46,49 corresponding to 425 patients, the rate of isolated epilepsy was 19.3% (82/ 425), whereas in the remaining 80.7% (343/425) an association with neurological impairment is reported, variably described in the relative studies. From the analysis of a subset of 16 studies 2,5,10,11,14,17e19, 23,29,32,33,35,40,42,45 which specified the type of associated neurological impairment, if present, in 243 patients with epilepsy, 18% (44/243) presented with epilepsy and intellectual impairment, 6.1% (15/243) with epilepsy and cerebral palsy, 44.8% (109/243) with epilepsy and both intellectual impairment and cerebral palsy.…”

Section: Resultsmentioning

confidence: 99%

Epilepsy after neonatal seizures: Literature review

Pisani

Facini

Pavlidis

et al. 2015

European Journal of Paediatric Neurology

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Section: Resultsmentioning

confidence: 99%

Epilepsy after neonatal seizures: Literature review

Pisani

Facini

Pavlidis

et al. 2015

European Journal of Paediatric Neurology

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“…Yet, the risk of postneonatal epilepsy in the first several years of life is less than 25% for neonates with acute symptomatic seizures and postneonatal epilepsies (particularly West Syndrome) do not necessarily respond to the medications prescribed in the neonatal period. 13–15 …”

Section: Discussionmentioning

confidence: 99%

Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study

Shellhaas

Chang

Wusthoff

et al. 2017

The Journal of Pediatrics

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“…PNE was defined as recurrent, unprovoked seizures that were present after the neonatal period (greater than 28 days). 15, 19, 20 …”

Section: Introductionmentioning

confidence: 99%

Early Anatomical Injury Patterns Predict Epilepsy in Head Cooled Neonates With Hypoxic-Ischemic Encephalopathy

Jung

Ritacco

Nordli

et al. 2015

Pediatric Neurology

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OBJECTIVE To determine whether early anatomical injury patterns in MRI correlate with the development of post-neonatal epilepsy in infants treated with selective head cooling for hypoxic ischemic encephalopathy. STUDY DESIGN A retrospective study of infants ≥35 weeks’ gestation born between 2008 and 2013 and followed for at least one year at Northwestern University. All had brain MRI at day 4–5 and EEGs during rewarming and at 3 to 6 months of age. RESULTS Outcome was favorable for our cohort of 73 with mean follow-up of 41 (± 7) months. The majority (66%) survived with no seizure recurrence, while 13 (18%) developed post neonatal epilepsy including 8, who had infantile spasms. Twelve infants (16%) died. The most common MRI pattern was diffuse brain injury involving both cortical and subcortical gray matter (26/73, 35%) followed by cortical and subcortical white matter injury (18/73, 25%), and normal MRI (16/73, 22%). In 13 infants (18%), the brainstem was involved in addition to cortical and subcortical gray matter; 9 died and all 4 surviving infants developed infantile spams. All 18 infants with cortical and subcortical white matter injury survived and none developed post neonatal epilepsy. Risk of post neonatal epilepsy was associated with injury involving subcortical regions (basal ganglia, thalamus ± brainstem) (12/39 vs 1/34, p<0.003). CONCLUSIONS Brainstem injury was highly predictive of infantile spams while cortical injury alone predicted low risk for short term post neonatal epilepsy. Location of anatomical injury on MRI can be an early predictive factor for development of infantile spams and inform prognostic decisions in newborns treated with selective head cooling for hypoxic ischemic encephalopathy.

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Development of epilepsy in newborns with moderate hypoxic-ischemic encephalopathy and neonatal seizures

Cited by 60 publications

References 31 publications

Epilepsy after neonatal seizures: Literature review

Epilepsy after neonatal seizures: Literature review

Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study

Early Anatomical Injury Patterns Predict Epilepsy in Head Cooled Neonates With Hypoxic-Ischemic Encephalopathy

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