Development of fast neurotransmitter synapses: General principle and recent progress

Lü, Wei; Chen, Yelin

doi:10.1016/j.brainresbull.2016.11.009

“…Understanding how synapses mature under standard developmental conditions allows us to define critical and sensitive periods in which environmental exposures and experience can lead to long-lasting alterations in the wiring and function of neuronal circuits. Developmental patterns of synapse assembly and maturation in projection neurons of forebrain regions such as the cortex and hippocampus have been well defined (7)(8)(9). It has become clear, however, that the course of synaptic maturation differs between cell types (1,9), and considerably less is known about maturational processes in midbrain and hindbrain regions.…”

Section: Introductionmentioning

confidence: 99%

Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons

Kisner

¹

,

Polter

²

2023

Preprint

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Serotonergic neurons in the dorsal raphe nucleus (DRN) play important roles early in postnatal development in the maturation and modulation of higher order emotional, sensory, and cognitive circuitry. This unique position makes these cells a substrate by which early experience can be wired into brain. In this study, we have investigated the maturation of synapses onto dorsal raphe serotonergic neurons in typically developing male and female mice using whole-cell patch-clamp recordings in ex vivo brain slices. We show that while inhibition of these neurons is relatively stable across development, glutamatergic synapses greatly increase in strength between P6 and P21-23. In contrast to forebrain regions, where the components making up glutamatergic synapses are dynamic across early life, we find that the makeup of these synapses onto DRN serotonergic neurons is largely stable after P15. DRN excitatory synapses maintain a very high ratio of AMPA to NMDA receptors and a rectifying component of the AMPA response throughout the lifespan. Overall, these findings reveal that the development of serotonergic neurons is marked by a significant refinement of glutamatergic synapses during the first 3 postnatal weeks. This suggests this time as a sensitive period of heightened plasticity for integration of information from upstream brain areas and that genetic and environmental insults during this period could lead to alterations in serotonergic output, impacting both the development of forebrain circuits and lifelong neuromodulatory actions.

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Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons

Kisner,

Polter

2024

Journal of Neurophysiology

1

0

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Serotonergic neurons in the dorsal raphe nucleus (DRN) play important roles early in postnatal development in the maturation and modulation of higher order emotional, sensory, and cognitive circuitry. This unique position makes these cells a substrate by which early experience can be wired into brain. In this study, we have investigated the maturation of synapses onto dorsal raphe serotonergic neurons in typically developing male and female mice using whole-cell patch-clamp recordings in ex vivo brain slices. We show that while inhibition of these neurons is relatively stable across development, glutamatergic synapses greatly increase in strength between P6 and P21-23. In contrast to forebrain regions, where the components making up glutamatergic synapses are dynamic across early life, we find that the makeup of these synapses onto DRN serotonergic neurons is largely stable after P15. DRN excitatory synapses maintain a very high ratio of AMPA to NMDA receptors and a rectifying component of the AMPA response throughout the lifespan. Overall, these findings reveal that the development of serotonergic neurons is marked by a significant refinement of glutamatergic synapses during the first 3 postnatal weeks. This suggests this time as a sensitive period of heightened plasticity for integration of information from upstream brain areas and that genetic and environmental insults during this period could lead to alterations in serotonergic output, impacting both the development of forebrain circuits and lifelong neuromodulatory actions.

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Neurological, psychiatric and psychosocial consequences of cardiosurgical interventions in the conditions of artificial blood circulation and general approaches to their prevention

Mankovskyi¹

2023

UVP

0

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Cardiac surgery is a modern, effective, and promising direction of treatment of patients with severe cardiac pathology. An integral component of modern surgical interventions on the heart is artificial blood circulation, which is accompanied by several risks for the patient both during the operation and in the postoperative period. Despite the improvement of the surgical technique and the technological support of sur- gical interventions on the heart, the expansion of the spectrum of indications for operations and the increase in the average age of patients, the frequency of postoperative complications in CPH remains high, and the search for ways to reduce them is an extremely important task of modern medical science and practice. Among the postoperative complications of CVC, a significant place belongs to neurologi- cal disorders cerebral infarction, postoperative encephalopathy, and postoperative cognitive dysfunction. Also, negative clinical-psychopathological and psychosocial consequences occupy a significant place. Current scientific data on the pathogenesis, clinical and phenomenologi- cal features, and ways of treatment and prevention of complications of CHD are incomplete, contra dictory, and require additional research. Based on the above, a conclusion was made about the relevance of a number of important problems regarding the treatment and rehabilitation of patients with neurological consequences of surgical interventions on the heart, which require careful study and further resolution.

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Development of fast neurotransmitter synapses: General principle and recent progress

Cited by 3 publications

References 24 publications

Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons

Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons

Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons

Neurological, psychiatric and psychosocial consequences of cardiosurgical interventions in the conditions of artificial blood circulation and general approaches to their prevention

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