Development of features of glomerulopathy in tumor-bearing rats: a potential model for paraneoplastic glomerulopathy

Takeda, Shin‐ichi; Chinda, Junko; Murakami, Takashi; Numata, Akihiko; Iwazu, Yoshitaka; Akimoto, Tetsu; Hamano, Yoshitomo; Muto, Shigeaki; Takahashi, Masafumi; Kusano, Eiji

doi:10.1093/ndt/gfr565

Cited by 23 publications

(32 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with malignancy have an increased prevalence of glomerular IgG deposits compared with noncancer patients; however, these deposits are mostly in the subendothelial or mesangial locales, rather than in subepithelium-like sites so typical of idiopathic MN (22). Experimentally, rats bearing transplanted colon cancer-derived tumors develop immune deposits and electron-dense deposits in glomeruli, but a picture of MN is not seen (23). To my knowledge, there are no animal models of MN due to transplanted, induced, or spontaneous malignancy, which creates a real deficit in our understanding of the relationship between MN and cancer.…”

Section: Discussionmentioning

confidence: 99%

Attending Rounds

Glassock

2012

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

SummaryNephrotic syndrome in older adult patients is a common clinical conundrum. Membranous nephropathy (MN) is a lesion frequently found to underlie the nephrotic state in such patients. Determining with reasonable certainty whether the nephrotic syndrome and MN is primary (idiopathic) or due to an underlying disease such as neoplasia can be a daunting clinical challenge. By way of a presentation of an illustrative case and a focused review of the relevant literature, the approach to evaluation of such patients, with an emphasis on the putative causative role of neoplasia in MN, is analyzed and a potential contemporary pathway for acquiring the correct diagnosis is offered.

show abstract

Section: Discussionmentioning

confidence: 99%

Attending Rounds

Glassock

2012

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…Interestingly, 9 of the 13 rats that had a normal immune system developed proteinuria and abundant IgG was noted in glomerular tufts, and electron microscopy showed foot process effacement and electron-dense deposits. 24 The T cell-depleted mice had no proteinuria and no specific immune response in the kidney, despite cancer growth. 24 The above study suggests that T-cell response might be critical in the development of paraneoplastic glomerular disease.…”

Section: Solid Organ Tumors and Other Glomerulopathiesmentioning

confidence: 98%

“…24 The T cell-depleted mice had no proteinuria and no specific immune response in the kidney, despite cancer growth. 24 The above study suggests that T-cell response might be critical in the development of paraneoplastic glomerular disease. Th1 (T helper type 1)-predominant responses have been associated with proliferative and crescentic forms of glomerulonephritis and Th2 (T helper type 2)-type responses with a membranous pattern of injury.…”

Section: Solid Organ Tumors and Other Glomerulopathiesmentioning

confidence: 98%

See 1 more Smart Citation

Glomerular diseases seen with cancer and chemotherapy: a narrative review

Jhaveri

Shah

Calderon

et al. 2013

Kidney International

124

View full text Add to dashboard Cite

Glomerular lesions have been recognized in a number of malignant diseases. Membranous nephropathy is the most common glomerular pathology associated with solid tumors. In Hodgkin's disease, the most common lesion is minimal change disease, reflecting possibly an anomaly of T-cell function. On the other hand, in patients with chronic lymphocytic leukemia, a large proportion of glomerular lesions fall into the category of membranoproliferative glomerulonephritis. Membranous nephropathy is also the most common glomerular disease seen following stem cell transplantation, suggesting a possible immune-mediated mechanism. Chemotherapy agents such as interferon, anti-vascular endothelial growth factor agents, tyrosine kinase inhibitors, and bisphosphonates have also been associated with various glomerular diseases and thrombotic microangiopathy. Failure to recognize certain paraneoplastic glomerular diseases can lead to potentially unnecessary therapies. This review describes the association of glomerular diseases with solid tumors, hematological malignancies, stem cell transplantation, and chemotherapeutic agents. We also describe the pitfalls in diagnosis and the dilemma in treating these entities.

show abstract

“…In a recent study, tumor-bearing rats developed features of glomerulopathy, and this animal model may provide new insights into the development of paraneoplastic glomerulopathies. [3]…”

Section: Introductionmentioning

confidence: 99%

Nephrotic syndrome associated with meningioma

Zachariah¹,

Mathew²,

Rajesh³

et al. 2013

Indian J Nephrol

View full text Add to dashboard Cite

A 58-year-old man presented with recurrent frontal meningioma and nephrotic syndrome. Renal biopsy could not be done in view of the rapid neurological deterioration. The patient underwent surgical resection of the tumor. Within 4 weeks, the edema decreased, serum albumin improved, and proteinuria decreased spontaneously. At three months of followup, the patient had attained complete remission of nephrotic state.

show abstract

Development of features of glomerulopathy in tumor-bearing rats: a potential model for paraneoplastic glomerulopathy

Abstract: The tumor-bearing rats developed features of glomerulopathy, as expected from the clinical perspective, and this animal model may provide new insights into the development of paraneoplastic glomerulopathies.

Cited by 23 publications

References 26 publications

Attending Rounds

Attending Rounds

Glomerular diseases seen with cancer and chemotherapy: a narrative review

Nephrotic syndrome associated with meningioma

Contact Info

Product

Resources

About