Development of fullerene nanospherical miRNA and application in overcoming resistant breast cancer

Xu, Jiaxi; Xie, Yangyang; Li, J.-W.; Liu, R.; Chen, M.; Ren, Yulin; Luo, Qianyi; Duan, Jianchun; Bao, Chang; Liu, Y.-X.; Li, P.-S.; Lu, Weirong

doi:10.1016/j.mtchem.2022.101019

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…59,72 The generated 1 O 2 could be further applied in the disease treatment, such as photodynamic therapy. 59,73 In this case, the light irradiation influence on the photo-oxidation rate of 9,10-anthracenediylbis-(methylene)dimalonic acid (ABDA, a probe to real-time monitor 1 O 2 generation; 15 μg/mL) was investigated. First, the pure ABDA (laser on) and ABDA&NPs 16 (laser off) were selected as control samples.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Not only that, it had been reported that the coexisting C 60 and IR780 could generate singlet oxygen ( 1 O 2 ) once they were subjected to a light irradiation with wavelength of 532 and 808 nm, respectively. , The generated 1 O 2 could be further applied in the disease treatment, such as photodynamic therapy. , In this case, the light irradiation influence on the photo-oxidation rate of 9,10-anthracenediylbis(methylene)dimalonic acid (ABDA, a probe to real-time monitor 1 O 2 generation; 15 μg/mL) was investigated. First, the pure ABDA (laser on) and ABDA&NPs 16 (laser off) were selected as control samples.…”

Section: Resultsmentioning

confidence: 99%

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Asymmetric Cyclodextrin-Dimer-Involved Nanoassemblies by Selective Host–Guest Interactions: Concentration-Dependent Morphology Evolution and Light-Regulated Biomedical Applications

Li,

Yan,

Jiang

et al. 2024

Biomacromolecules

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Supramolecular assembly has attracted significant attention and has been applied to various applications. Herein, a β−γ-CD dimer was synthesized to complex different guest molecules, including single-strand polyethylene glycol (PEG)modified C 60 (PEG-C 60 ), photothermal conversion reagent (IR780), and dexamethasone (Dexa), according to the complexation constant-dependent specific selectivity. Spherical or cylindrical nanoparticles, monolayer or bilayer vesicles, and bilayer fusion vesicles were discovered in succession if the concentration of PEG-C 60 was varied. Moreover, if near-infrared light was employed to irradiate these nanoassemblies, the thermo-induced morphological evolution, subsequent cargo release, photothermal effect, and singlet oxygen ( 1 O 2 ) generation were successfully achieved. The in vitro cell experiments confirmed that these nanoparticles possessed excellent biocompatibility in a normal environment and achieved superior cytotoxicity by light regulation. Such proposed strategies for the construction of multilevel structures with different morphologies can open a new window to obtain various host−guest functional materials and achieve further use for disease treatment.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Asymmetric Cyclodextrin-Dimer-Involved Nanoassemblies by Selective Host–Guest Interactions: Concentration-Dependent Morphology Evolution and Light-Regulated Biomedical Applications

Li,

Yan,

Jiang

et al. 2024

Biomacromolecules

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“…On the other hand, fullerene nanospheres stimulated ROS production under 365 nm irradiation. Altogether, ROS output, along with CREB1 and CYP1B1 downregulation, reverted PTX recalcitrance, allowing apoptosis and suppression of metastasis in resistant breast cancer cells in both in vivo and in vitro assays (Xu et al, 2022) (Figure 3C).…”

Section: Breast Cancermentioning

confidence: 99%

“…To carry out this experiment, single-stranded miR-27b was conjugated with fullerene C 60 (also known as buckminsterfullerene) to synthesize a fullerene nanospherical miRNA. This nanocarrier was then phagocytized by the cells, where miR-27b is being released (Xu et al, 2022). Subsequently, this miRNA triggered the downregulation of cyclic adenosine monophosphate responsive element binding protein 1 (CREB1) and cytochrome P450 family 1 subfamily B member 1 (CYP1B1) proteins at the transcriptional level.…”

Section: Breast Cancermentioning

confidence: 99%

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

Bravo-Vázquez,

Méndez-García,

Rodríguez

et al. 2023

Front. Bioeng. Biotechnol.

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MicroRNAs (miRNAs) are short (18–25 nt), non-coding, widely conserved RNA molecules responsible for regulating gene expression via sequence-specific post-transcriptional mechanisms. Since the human miRNA transcriptome regulates the expression of a number of tumor suppressors and oncogenes, its dysregulation is associated with the clinical onset of different types of cancer. Despite the fact that numerous therapeutic approaches have been designed in recent years to treat cancer, the complexity of the disease manifested by each patient has prevented the development of a highly effective disease management strategy. However, over the past decade, artificial miRNAs (i.e., anti-miRNAs and miRNA mimics) have shown promising results against various cancer types; nevertheless, their targeted delivery could be challenging. Notably, numerous reports have shown that nanotechnology-based delivery of miRNAs can greatly contribute to hindering cancer initiation and development processes, representing an innovative disease-modifying strategy against cancer. Hence, in this review, we evaluate recently developed nanotechnology-based miRNA drug delivery systems for cancer therapeutics and discuss the potential challenges and future directions, such as the promising use of plant-made nanoparticles, phytochemical-mediated modulation of miRNAs, and nanozymes.

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“…Fullerene, a carbonaceous nanomaterial with significant penetration into solid tumors and strong chemical reactivity, has received substantial attention in cancer theranostics 18 , 19 . In addition, it is possible to functionalize fullerenes to give them unique physicochemical properties including biocompatibility and water solubility 20 , 21 . Moreover, a combined application of the fullerene nanocore's photodynamic action can be employed to increase the effectiveness of chemotherapy 20 .…”

Section: Introductionmentioning

confidence: 99%

Nanocomposite fibers based on cellulose acetate loaded with fullerene for cancer therapy: preparation, characterization and in-vitro evaluation

El Fawal,

Abu-Serie,

Ali

et al. 2023

Sci Rep

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The current prevalence of cancerous diseases necessitates the exploration of materials that can effectively treat these conditions while minimizing the occurrence of adverse side effects. This study aims to identify materials with the potential to inhibit the metastasis of cancerous diseases within the human body while concurrently serving as therapeutic agents for their treatment. A novel approach was employed to enhance the anti-cancer properties of electrospun cellulose fibers by incorporating fullerene nanoparticles (NPs) into cellulose acetate (CA) fibers, resulting in a composite material called Fullerene@CA. This development aimed at utilizing the anti-cancer properties of fullerenes for potential therapeutic applications. This process has been demonstrated in vitro against various types of cancer, and it was found that Fullerene@CA nanocomposite fibers displayed robust anticancer activity. Cancer cells (Caco-2, MDA-MB 231, and HepG-2 cells) were inhibited by 0.3 and 0.5 mg.g−1 fullerene doses by 58.62–62.87%, 47.86–56.43%, and 48.60–57.73%, respectively. The tested cancer cells shrink and lose their spindle shape due to morphological changes. The investigation of the prepared nanocomposite reveals its impact on various genes, such as BCL2, NF-KB, p53, Bax, and p21, highlighting the therapeutic compounds' effectiveness. The experimental results demonstrated that the incorporation of NPs into CA fibers resulted in a significant improvement in their anti-cancer efficacy. Therefore, it is suggested that these modified fibers could be utilized as a novel therapeutic approach for the treatment and prevention of cancer metastasis.

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Development of fullerene nanospherical miRNA and application in overcoming resistant breast cancer

Cited by 8 publications

References 40 publications

Asymmetric Cyclodextrin-Dimer-Involved Nanoassemblies by Selective Host–Guest Interactions: Concentration-Dependent Morphology Evolution and Light-Regulated Biomedical Applications

Asymmetric Cyclodextrin-Dimer-Involved Nanoassemblies by Selective Host–Guest Interactions: Concentration-Dependent Morphology Evolution and Light-Regulated Biomedical Applications

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

Nanocomposite fibers based on cellulose acetate loaded with fullerene for cancer therapy: preparation, characterization and in-vitro evaluation

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