Development of fully‐automated synthesissystems

Sugawara, Tohru; Katō, Susumu; Okamoto, Shunya

doi:10.1155/s1463924694000039

Cited by 21 publications

(6 citation statements)

References 3 publications

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“…However, developing new chemical processes, or modifying established manual ones, is also very important for us to increase the scope, efficiency and reliability of automated synthesis. 10) were used to synthesize oligopeptide derivatives in solution. Optical rotation values (in MeOH) were measured with a Nihon Bunko DIP-370 spectrometer.…”

Section: Resultsmentioning

confidence: 99%

Solution-Phase Automated Synthesis of Tripeptide Derivatives.

Kuroda

Hattori

Kitada

et al. 2001

CHEMICAL & PHARMACEUTICAL BULLETIN

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An improved general method for automated synthesis of tripeptides was developed, in which methanesulfonic acid (MSA) was used in place of trifluoroacetic acid (TFA), thus making it possible to avoid, 1) corrosion of the apparatus by strong acid vapor, 2) formation of emulsions, and 3) use of the restricted solvent, dichloromethane. As an application of the automated synthesis apparatus, 216 fragment tripeptide derivatives were synthesized systematically using the MSA method, in excellent yield and with increased efficiency.

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Section: Resultsmentioning

confidence: 99%

Solution-Phase Automated Synthesis of Tripeptide Derivatives.

Kuroda

Hattori

Kitada

et al. 2001

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…MEDLEY has not yet been installed in the workup and analysis units. We did not lay the priority on these technologies at the first stage of this project because technical problems for these goals have been fully cleared already. 1c, The utilization of the apparatus in synthetic processes will be described in the following paper.…”

Section: Resultsmentioning

confidence: 99%

Automated Synthesis: Development of a New Apparatus Friendly to Synthetic Chemists (MEDLEY)

Orita

Yasui

Otera

2000

Org. Process Res. Dev.

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A new type of automated synthesizer has been developed on which a variety of synthetic reactions can be conducted. Since the apparatus is completely sealed, reactions which require an inert atmosphere are feasible without difficulty. The reaction temperature is changeable from the temperature of dry ice to room temperature. The temperature is controlled within ±0.1 °C. The amount of reagents added is accurate within ±0.01 mL. With the advanced control function, the process time is minimized. Thus, the apparatus is particularly convenient for running multifold reactions sequentially.

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“…In each of the foregoing conventional auto- Automated experiment devices of this kind can be broadly classified into five categories, as shown in Table 1: (1) systems that control reaction conditions by controlling parameters such as temperature, pressure, and flow, precision measuring of heat balance, and analyzing reaction parameters; (2) sequential apparatus for synthesizing samples of small quantity by performing tasks such as synthesis, post-processing, and refinement [2,3]; and (3) devices to perform synthesis, post-processing, and analysis for optimization of reaction conditions; (4) systems for combinatorial chemistry, or high-throughput screening, and (5) microreactors based on microreaction technology.…”

Section: Laboratory Automationmentioning

confidence: 99%

Design of a robotic workstation for automated organic synthesis

Okamoto

Deuchi

2000

Lab. Robotics Autom.

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A robotic workstation for automated organic synthesis was developed. The system consists of a computer, robot, and several devices (reaction device, separation device, dispense device, etc.). The reaction device has four temperature-regulation units, each of which can freely change its set reaction temperature. Since each of the four can handle four reaction containers, 16 reactions under different conditions can be done simultaneously. The range of reaction temperature is from ‫03מ‬ЊC to 160ЊC. Reactions beyond the boiling points of solvents are possible by using reflux condensers. The separation processing device automatically performs solution extraction operations based on the detected liquid levels and interface positions. The dispensing device automatically pumps various kinds and amounts of reagents and/or solvents at various speeds into the reaction containers by switching valves through the digital syringe pump. This system can automate all synthesis and analysis process and can perform at least 3000 experiments (3000 containers) per year.

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Development of fully‐automated synthesissystems

Cited by 21 publications

References 3 publications

Solution-Phase Automated Synthesis of Tripeptide Derivatives.

Solution-Phase Automated Synthesis of Tripeptide Derivatives.

Automated Synthesis: Development of a New Apparatus Friendly to Synthetic Chemists (MEDLEY)

Design of a robotic workstation for automated organic synthesis

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