Development of functional gastrointestinal disorders after Giardia lambliainfection

Hanevik, Kurt; Dizdar, Vernesa; Langeland, Nina; Hausken, Trygve

doi:10.1186/1471-230x-9-27

Cited by 148 publications

(118 citation statements)

References 26 publications

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“…The G. intestinalis infection has been found to trigger abdominal symptoms of functional gastrointestinal disorders such as irritable bowel syndrome and functional dyspepsia [16,17,18]. In Egypt, in which Giardia is endemic, the prevalence of G. intestinalis was 44% (96/220) among patients with dyspepsia [3].…”

Section: Discussionmentioning

confidence: 99%

Molecular Identification of Giardia intestinalis in Patients with Dyspepsia

Fouad¹,

Esmat²,

Basyoni

et al. 2014

Digestion

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Background/Aims:Giardia intestinalis triggers symptoms of functional dyspepsia. The aim of this study was to distinguish genotypes of G. intestinalis isolated from dyspeptic patients to evaluate their correlation with dyspeptic symptoms. Methods: In total, 120 dyspeptic subjects were investigated by upper endoscopy, including gastric and duodenal biopsies for histopathological examination, and parasitological examination of their stools and duodenal aspirates was performed. The patients were classified into five groups: group I (G. intestinalis) included 19 patients, group II (Helicobacter pylori) included 36 patients, group III (coeliac disease) included 3 patients, group IV (mixed G. intestinalis and H. pylori infection) included 4 patients, and group V (unexplained aetiology) included 58 patients. Genotyping of G. intestinalis was performed for groups I and IV using PCR-RFLP. The urease test was performed for H. pylori. Serum anti-gliadin, anti-endomysial and anti-transglutaminase antibody estimation was performed for the diagnosis of coeliac disease. Results: Genotype A of G. intestinalis was detected in the stool samples of 68.42% (13/19) and the duodenal aspirates of 42.1% (8/19) of dyspeptic patients harbouring the parasite. Genotype B was detected in 31.58% (6/19) of cases in stool samples and in 3 cases in duodenal aspirates. Conclusions:H. pylori, G. intestinalis and coeliac disease are common causes of dyspepsia. G. intestinalis genotype A demonstrated a greater association with dyspeptic symptoms.

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Section: Discussionmentioning

confidence: 99%

Molecular Identification of Giardia intestinalis in Patients with Dyspepsia

Fouad¹,

Esmat²,

Basyoni

et al. 2014

Digestion

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“…Porém, em alguns casos, pode causar danos à mucosa e consequentemente gerar distúrbios gastrointestinais, dos quais a diarreia disabsortiva é o sintoma mais relatado 6,7 . Ocasionalmente, tem sido relatada a associação de infecção por G. lamblia com urticária e prurido 8 , uveíte 9 e até mesmo com sensibilização para antígenos alimentares, o que fez surgir hipóteses de algum nexo causal entre essas doenças e as protozooses 7,10 .…”

Section: Introductionunclassified

Giardia lamblia and respiratory allergies: a study of children from an urban area with a high incidence of protozoan infections

Souza¹,

Sales²,

Peixoto³

et al. 2012

J Pediatr (Rio J)

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Objectives: There is a high incidence of intestinal parasite infection in urban areas in the Northeast of Brazil. Giardia lamblia infections have been associated with increased prevalence of cutaneous allergies and gastrointestinal disorders. However, little is known about the relationship between giardiasis and allergic diseases of the airways. The present study aimed to investigate the possible association between respiratory allergic diseases and infections by G. lamblia in children from urban areas. Methods:This study recruited 110 patients of both sexes aged 5-15 years. Patients were administered a questionnaire evaluating clinical symptoms and were given skin tests, parasite tests and serum tests. Results:A high incidence of G. lamblia was observed (45%, 50/110). Infections by this protozoan were not associated with increased risk of respiratory allergy (p = 0.075), high total IgE levels (p = 0.701), positive specific IgE tests (p = 0.250), or positive skin tests for a range of environmental allergens (p = 0.239). Conclusion:This study demonstrated that symptoms of asthma, skin allergy and serum markers were not associated with G. lamblia infections in this sample of children from urban areas.J Pediatr (Rio J). 2012;88(3):233-8: Giardia lamblia, rhinitis, asthma, skin prick test. ResumoObjetivo: Uma elevada incidência de enteroparasitoses é encontrada em regiões urbanas do nordeste brasileiro. As infecções por Giardia lamblia têm sido relacionadas com aumento da prevalência de alergias cutâneas e gastrointestinais. Contudo, ainda existe pouca informação sobre a associação entre a giardíase e doenças alérgicas das vias aéreas. Diante disso, o presente estudo se propôs a verificar a relação entre a infecção por G.lamblia em crianças de área urbana e reatividade alérgica respiratória.Métodos: O estudo incluiu 110 pacientes, de ambos os sexos e idades, entre 5 e 15 anos. Os pacientes foram submetidos a questionários de avaliação dos sintomas clínicos, testes cutâneos de leitura imediata e exames coproparasitológicos e sorológicos.Resultados: Foi verificada uma frequência elevada de crianças infectadas por G. lamblia (45%, 50/110). A infecção pelo protozoário não foi associada com maior risco de alergias respiratórias (p = 0,075), elevação de IgE total (p = 0,701), IgE específica (p = 0,250) ou teste cutâneo positivo para diferentes alérgenos ambientais (p = 0,239). Conclusão:O estudo demonstrou que a presença dos sintomas de asma, atopia cutânea e marcadores sorológicos não foram associados com a presença de infecção pela G. lamblia nessa amostra de crianças.J Pediatr (Rio J). 2012;88(3):233-8: Giardia lamblia, rinite, asma, teste cutâneo.

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“…However, this is unsupported, since many long-term infections are suspected to represent either persisting abdominal symptoms elicited post-Giardia infection or reinfections (176,196,484). The fecal-oral route still remains the most important mode of infection (33), and various studies have found evidence of zoonotic transmission (89,118,237).…”

Section: Giardia Intestinalismentioning

confidence: 99%

Enteric Protozoa in the Developed World: a Public Health Perspective

et al. 2012

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SUMMARY Several enteric protozoa cause severe morbidity and mortality in both humans and animals worldwide. In developed settings, enteric protozoa are often ignored as a cause of diarrheal illness due to better hygiene conditions, and as such, very little effort is used toward laboratory diagnosis. Although these protozoa contribute to the high burden of infectious diseases, estimates of their true prevalence are sometimes affected by the lack of sensitive diagnostic techniques to detect them in clinical and environmental specimens. Despite recent advances in the epidemiology, molecular biology, and treatment of protozoan illnesses, gaps in knowledge still exist, requiring further research. There is evidence that climate-related changes will contribute to their burden due to displacement of ecosystems and human and animal populations, increases in atmospheric temperature, flooding and other environmental conditions suitable for transmission, and the need for the reuse of alternative water sources to meet growing population needs. This review discusses the common enteric protozoa from a public health perspective, highlighting their epidemiology, modes of transmission, prevention, and control. It also discusses the potential impact of climate changes on their epidemiology and the issues surrounding waterborne transmission and suggests a multidisciplinary approach to their prevention and control.

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Development of functional gastrointestinal disorders after Giardia lambliainfection

Cited by 148 publications

References 26 publications

Molecular Identification of <b><i>Giardia intestinalis</i></b> in Patients with Dyspepsia

Molecular Identification of <b><i>Giardia intestinalis</i></b> in Patients with Dyspepsia

<i>Giardia lamblia</i> and respiratory allergies: a study of children from an urban area with a high incidence of protozoan infections

Enteric Protozoa in the Developed World: a Public Health Perspective

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