Development of Gold-PAGE: towards the electrophoretic analysis of sulphurous biopolymers

Taylor, Emerald; Cavuoto, Silvia; Béal, David; Caujolle, Sophie; Podoleanu, Adrian Gh.; Serpell, Christopher J.

doi:10.1039/c9tb00665f

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…85 The use of human SA as drug carrier is based on the fact that SA is an important carrier of endogenous and exogenous hydrophobic molecules in the human circulation. 138 Studies have demonstrated that the SA-bound paclitaxel formulation differs favorably from unbound paclitaxel in terms of tumor accumulation of SA, patient toleration, response rate, and extends the time to tumor progression. 139 Besides Abraxane, an active-targeted NP, Rexin-G, is commercially available outside of the USA (Table 1) and there are other drug nanocarriers that incorporate an active targeting ligand in clinical trials (eg, HA-Irinotecan in phase III and RGD-PET-CT in phase II).…”

Section: Lectinsmentioning

confidence: 99%

<p>Smart Targeting To Improve Cancer Therapeutics</p>

Morales‐Cruz¹,

Delgado²,

Castillo³

et al. 2019

DDDT

109

101

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Cancer is the second largest cause of death worldwide with the number of new cancer cases predicted to grow significantly in the next decades. Biotechnology and medicine can and should work hand-in-hand to improve cancer diagnosis and treatment efficacy. However, success has been frequently limited, in particular when treating late-stage solid tumors. There still is the need to develop smart and synergistic therapeutic approaches to achieve the synthesis of strong and effective drugs and delivery systems. Much interest has been paid to the development of smart drug delivery systems (drug-loaded particles) that utilize passive targeting, active targeting, and/or stimulus responsiveness strategies. This review will summarize some main ideas about the effect of each strategy and how the combination of some or all of them has shown to be effective. After a brief introduction of current cancer therapies and their limitations, we describe the biological barriers that nanoparticles need to overcome, followed by presenting different types of drug delivery systems to improve drug accumulation in tumors. Then, we describe cancer cell membrane targets that increase cellular drug uptake through active targeting mechanisms. Stimulusresponsive targeting is also discussed by looking at the intra-and extracellular conditions for specific drug release. We include a significant amount of information summarized in tables and figures on nanoparticle-based therapeutics, PEGylated drugs, different ligands for the design of active-targeted systems, and targeting of different organs. We also discuss some still prevailing fundamental limitations of these approaches, eg, by occlusion of targeting ligands.

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Section: Lectinsmentioning

confidence: 99%

<p>Smart Targeting To Improve Cancer Therapeutics</p>

Morales‐Cruz¹,

Delgado²,

Castillo³

et al. 2019

DDDT

109

101

View full text Add to dashboard Cite

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Efficient multiphoton absorption of near-infrared emitting Cu-doped ZnInS/ZnS nanocrystals

Gao

Liu

et al. 2020

J. Phys. D: Appl. Phys.

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Due to their unique optoelectronic properties, doped semiconductor nanocrystals (NCs) are promising fluorescent probes for deep-tissue bioimaging applications. However, studies on the photophysical properties of cadmium-free doped NCs are scarce. In this study, we synthesized and studied the photophysical properties of one type of cadmium-free doped NCs (Cu: ZnInS/ZnS NCs), which exhibit near infrared-I (NIR-I) emission at 730 nm and long emission lifetime up to 1.38 μs. Femtosecond transient absorption spectra revealed a strong exciton coupling effect between the Cu2+ ions and the ZnInS/ZnS host, with a fast energy transfer time of ≈100 ps. More importantly, Cu: ZnInS/ZnS NCs exhibit efficient volume-normalized two- and three-photon absorption cross-sections in NIR-I (800–900 nm) and NIR-III regions (1600–1990 nm), with maximum values up to 6.9 GM nm−3 at 800 nm and 1.1 × 10−80 cm6 s2 photon−2 nm−3 at 1600 nm, respectively. This study can shed light on the exploration of novel environmentally friendly doped NCs for deep-tissue bioimaging applications.

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Development of Gold-PAGE: towards the electrophoretic analysis of sulphurous biopolymers

Abstract: Gold nanoparticles, encapsulated within polyacrylamide electrophoresis gels, can discriminate between number of type of sulphur modifications in DNA strands.

Cited by 2 publications

References 26 publications

<p>Smart Targeting To Improve Cancer Therapeutics</p>

<p>Smart Targeting To Improve Cancer Therapeutics</p>

Efficient multiphoton absorption of near-infrared emitting Cu-doped ZnInS/ZnS nanocrystals

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