Development of hydrophilic nanocarriers for the charged form of the local anesthetic articaine

Melo, Nathalie Ferreira Silva de; Campos, Estefânia Vangelie Ramos; Gonçalves, Camila Morais; Paula, Eneida de; Pasquoto, Tatiane; Lima, Renata de; Rosa, André Henrique; Fraceto, Leonardo Fernandes

doi:10.1016/j.colsurfb.2014.05.035

Cited by 33 publications

(36 citation statements)

References 46 publications

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“…The results were shown as the means of five measures (mean ± SD). The physicochemical stability of the nanoparticles was evaluated as a function of time, analyzing the suspension over 120 days [15,21,24]. …”

Section: Methodsmentioning

confidence: 99%

15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation

et al. 2016

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15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has physiological properties including pronounced anti-inflammatory activity, though it binds strongly to serum albumin. The use of solid lipid nanoparticles (SLN) can improve therapeutic properties increasing drug efficiency and availability. 15d-PGJ2-SLN was therefore developed and investigated in terms of its immunomodulatory potential. 15d-PGJ2-SLN and unloaded SLN were physicochemically characterized and experiments in vivo were performed. Animals were pretreated with 15d-PGJ2-SLN at concentrations of 3, 10 or 30 μg·kg-1 before inflammatory stimulus with carrageenan (Cg), lipopolysaccharide (LPS) or mBSA (immune response). Interleukins (IL-1β, IL-10 and IL-17) levels were also evaluated in exudates. The 15d-PGJ2-SLN system showed good colloidal parameters and encapsulation efficiency of 96%. The results showed that the formulation was stable for up to 120 days with low hemolytic effects. The 15d-PGJ2-SLN formulation was able to reduce neutrophil migration in three inflammation models tested using low concentrations of 15d-PGJ2. Additionally, 15d-PGJ2-SLN increased IL-10 levels and reduced IL-1β as well as IL-17 in peritoneal fluid. The new 15d-PGJ2-SLN formulation highlights perspectives of a potent anti-inflammatory system using low concentrations of 15d-PGJ2.

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Section: Methodsmentioning

confidence: 99%

15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation

et al. 2016

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“…1A)exhibited 7 sharp peaks for both PEG and PCL block, which indicates that there is fast molecular motion of 8 each block without molecular motion restriction. By contrast, in D2O appearance of sharp peaks 9 of the PEG (b) moiety were found, but the PCL peaks were collapsed and broadened (c, d, e, f)10 implying that the molecular motion of PCL chains in water is restricted, and a micelle structure11 with a PCL core and PEG shell is formed in water (Fig. 1B).…”

mentioning

confidence: 90%

“…CD spectrum confirmed that the secondary structure of insulin remains stable after preparation of nanoparticles. These results indicate that PEG-PCL block copolymer micelles prepared via heat-chill method may potentially be used for sustained release of labile proteins and secured delivery of similar biomolecules.Authors are thankful to Mr. Bodhisatwa Das, Mr. Prabhash Dadhich and Nantu Dogra for their10 assistance in cytotoxicity measurement. We wish to thank Ms. Sayanti Datta for her assistance in11 sample preparations.…”

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confidence: 99%

“…Insulin was used as a model protein to determine the protein release behavior of the micelles. 10 The dialysis bag diffusion technique was used to assay in vitro release behavior as reported …”

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confidence: 99%

“…At 25 present, these molecules are administered to the body by frequent subcutaneous and 26 intramuscular injections. Amphiphilic block copolymer based nanocarriers have been extensively 27 studied for drug delivery, protein delivery, gene delivery and in medical diagnosis [8][9][10]. 28 Amphiphilic nanoparticles prepared from polyethylene glycol and polycaprolactone (PCL) are 29 well studied and found to be incredibly useful for drug and protein delivery applications [11][12][13][14].…”

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confidence: 99%

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Organic solvent-free low temperature method of preparation for self assembled amphiphilic poly(ϵ-caprolactone)–poly(ethylene glycol) block copolymer based nanocarriers for protein delivery

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Nanomedicine and voltage-gated sodium channel blockers in pain management: a game changer or a lost cause?

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Development of hydrophilic nanocarriers for the charged form of the local anesthetic articaine

Cited by 33 publications

References 46 publications

15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation

15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation

Organic solvent-free low temperature method of preparation for self assembled amphiphilic poly(ϵ-caprolactone)–poly(ethylene glycol) block copolymer based nanocarriers for protein delivery

Nanomedicine and voltage-gated sodium channel blockers in pain management: a game changer or a lost cause?

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