Development of improved vaccines against whooping cough: Current status

Marzouqi, Ibrahim; Richmond, Peter; Fry, Scott; Wetherall, J. D.; Mukkur, T.K.S.

doi:10.4161/hv.6.7.11413

Cited by 29 publications

(28 citation statements)

References 138 publications

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“…Even with the use of pertussis vaccines, the incidence of Bordetella infections is very high, with 40-50 million cases reported worldwide each year (Marzouqi et al, 2010). Of these, 300,000-400,000 result in death, mostly in children living in developing countries (Marzouqi et al, 2010). This makes whooping cough the most common vaccine-preventable disease in the world (Marzouqi et al, 2010).…”

Section: Bordetellamentioning

confidence: 99%

“…In addition to the cough itself, other symptoms can include fever, nausea, convulsions, pneumonia, and, in severe cases, encephalopathy (Marzouqi et al, 2010). Even with the use of pertussis vaccines, the incidence of Bordetella infections is very high, with 40-50 million cases reported worldwide each year (Marzouqi et al, 2010).…”

Section: Bordetellamentioning

confidence: 99%

“…Of these, 300,000-400,000 result in death, mostly in children living in developing countries (Marzouqi et al, 2010). This makes whooping cough the most common vaccine-preventable disease in the world (Marzouqi et al, 2010).…”

Section: Bordetellamentioning

confidence: 99%

“…Bordetella pertussis is the bacterium responsible for whooping cough, a disease that can afflict all age groups, but which is especially predominant and dangerous in children (Dunne et al, 2009;Marzouqi et al, 2010). In addition to the cough itself, other symptoms can include fever, nausea, convulsions, pneumonia, and, in severe cases, encephalopathy (Marzouqi et al, 2010).…”

Section: Bordetellamentioning

confidence: 99%

See 3 more Smart Citations

The Contrasting Roles of T Regulatory Cells in Bacterial Lung Diseases

Odeh¹,

Simecka²

2012

Respiratory Diseases

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Section: Bordetellamentioning

confidence: 99%

Section: Bordetellamentioning

confidence: 99%

Section: Bordetellamentioning

confidence: 99%

Section: Bordetellamentioning

confidence: 99%

See 2 more Smart Citations

The Contrasting Roles of T Regulatory Cells in Bacterial Lung Diseases

Odeh¹,

Simecka²

2012

Respiratory Diseases

View full text Add to dashboard Cite

“…Basic manufacturing procedures are similar, however vaccines elicit very diverse antibody responses against different B. pertussis antigens. 40 The clinical efficacy of the different whole-cell vaccines was evaluated in a number of experimental studies leading to extremely variable results (36-96%) and this wide variability, associated with high reactogenicity, was the main limitation to the use of this type of vaccine. [41][42][43] Cellular vaccines were evaluated in controlled clinical trials that demonstrated their impact in terms of reduction of incidence and mortality rates whenever they were used on a large scale.…”

Section: Prevention: Currently Available Vaccinesmentioning

confidence: 99%

Pertussis

Gabutti

Azzari

Bonanni

et al. 2014

Human Vaccines & Immunotherapeutics

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Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance

Dorji

Mooi

Yantorno

et al. 2017

Med Microbiol Immunol

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Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced the mortality due to pertussis. Despite induction of both antibody and cell-mediated immune (CMI) responses by aP and wP vaccines, there has been resurgence of pertussis in many countries in recent years. Possible reasons hypothesised for resurgence have ranged from incompliance with the recommended vaccination programmes with the currently used aP vaccine to infection with a resurged clinical isolates characterised by mutations in the virulence factors, resulting in antigenic divergence with vaccine strain, and increased production of pertussis toxin, resulting in dampening of immune responses. While use of these vaccines provide varying degrees of protection against whooping cough, protection against infection and transmission appears to be less effective, warranting continuation of efforts in the development of an improved pertussis vaccine formulations capable of achieving this objective. Major approaches currently under evaluation for the development of an improved pertussis vaccine include identification of novel biofilm-associated antigens for incorporation in current aP vaccine formulations, development of live attenuated vaccines and discovery of novel non-toxic adjuvants capable of inducing both antibody and CMI. In this review, the potential roles of different accredited virulence factors, including novel biofilm-associated antigens, of B. pertussis in the evolution, formulation and delivery of improved pertussis vaccines, with potential to block the transmission of whooping cough in the community, are discussed.

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Development of improved vaccines against whooping cough: Current status

Cited by 29 publications

References 138 publications

The Contrasting Roles of T Regulatory Cells in Bacterial Lung Diseases

The Contrasting Roles of T Regulatory Cells in Bacterial Lung Diseases

Pertussis

Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance

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