Pertussis

Gabutti, Giovanni; Azzari, Chiara; Bonanni, Paolo; Prato, Rosa; Tozzi, Alberto Eugenio; Zanetti, Alessandro; Zuccotti, Gian Vincenzo

doi:10.4161/hv.34364

Cited by 49 publications

(52 citation statements)

References 101 publications

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“…Recently, more sensitive detection methods, including PCRs or serological assays of antibody titers against pertussis antigens, have allowed for a more sensitive measure of pertussis in adults. Using these methods, several studies identified pertussis as a frequent cause of prolonged cough in adults, supporting further the concept that pertussis burden in this age group is underappreciated and under-diagnosed [26,27].…”

Section: Discussionmentioning

confidence: 87%

“…Furthermore, pertussis in this age group may have been largely ignored due to lack of awareness on adult pertussis as well as diagnostic facilities and the reliance on clinical diagnosis [26]. From an epidemiological point of view regarding pertussis being important public-health issue, a major role is played by this age group who is a significant source of infection for unvaccinated or incompletely immunized newborns/infants in whom the severity of the disease can be serious [26]. Recently, more sensitive detection methods, including PCRs or serological assays of antibody titers against pertussis antigens, have allowed for a more sensitive measure of pertussis in adults.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Recurrent Cough Syncope Due to Pertussis in Adults: Report of Three Cases and Review of the Literature

et al. 2016

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Cough syncope, also called "tussive syncope", is a well-recognized syndrome for about 70 years, in which loss of consciousness usually occurs immediately after a violent cough or prolonged bouts of violent coughing, lasting for seconds with rapid restoration of full consciousness. Its precise pathophysiologic mechanism is not fully understood and remains a matter of debate. Although pertussis is a frequent cause of prolonged cough in adults, still its burden in this age group is under-appreciated and under-diagnosed worldwide. This is well reflected by the fact that despite cough syncope is definitely not rare, until yet only six cases of cough syncope related to pertussis have been reported in the medical literature, one of them by us. We describe additional three adults with recurrent cough syncope due to pertussis who were diagnosed during a period of 3 months which completely resolved by treatment with azithromycin. Diagnosing four cases of cough syncope in adults due to pertussis during a short period in one Department of Internal Medicine, while only five cases were reported from the rest of the world, reflects the great lack of awareness on adult pertussis worldwide. Our four cases indicate that physicians should be much more aware of pertussis as a cause of cough and cough syncope in adults in order to terminate the attacks of cough and cough syncope and its serious complications by adequate antibiotic treatment, as happened with our four patients.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Recurrent Cough Syncope Due to Pertussis in Adults: Report of Three Cases and Review of the Literature

et al. 2016

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“…[48] An advantage of whole-cell vaccines is that they include molecules that act as pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide (LPS), which are recognized by host antigen presenting cells, and present antigens in their natural configuration. [49,50] Children immunized with the whole-cell pertussis vaccine mainly generate a Th1 response that may in part be due to the presence of LPS and/or peptidoglycan, TLR agonists. [49] Therefore, it is no surprise that whole-cell pertussis vaccines induce immune responses similar to what is observed during natural infection.…”

Section: Pneumococcal Whole Cell Vaccinementioning

confidence: 99%

“…[49,50] Children immunized with the whole-cell pertussis vaccine mainly generate a Th1 response that may in part be due to the presence of LPS and/or peptidoglycan, TLR agonists. [49] Therefore, it is no surprise that whole-cell pertussis vaccines induce immune responses similar to what is observed during natural infection. [51] Although both whole-cell and acellular purified protein-based pertussis vaccines provide good protection, whole-cell pertussis vaccine are more efficacious and produce longer lasting immunity than acellular vaccines.…”

Section: Pneumococcal Whole Cell Vaccinementioning

confidence: 99%

Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

Pichichero

2017

Expert Review of Vaccines

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Introduction. Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future formulations of pneumococcal conjugate vaccines (PCVs) are needed and there may need to be continued reformulations because there are many new emerging serotypes expressed by pneumococci. Areas Covered: Mechanisms of protection by next-generation whole-cell vaccine (WCV) and/or multi-component pneumococcal purified protein vaccines (PPVs) in development for prevention of pneumococcal infections. Expert Commentary: A long-term strategy for prevention of pneumococcal disease will likely include WCV and PPVs. However these vaccines will impact disease pathogenesis in a different manner than PCVs. Prevention of pneumococcal NP colonization should not be expected, nor is it desirable because risks for NP colonization by other replacement organisms into the ecological niche vacated by all pneumococci may have consequences. The expression biology of capsule and surface protein antigens are phase dependent. Therefore, the immune response will be different and the mechanism of protection divergent. WCVs and PPVs may be alternative strategies in low income developing countries to protect against invasive disease and reduce NP carriage load.

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“…La coqueluche est une infection des voies respiratoires causée par les bactéries Bordetella pertussis et B. parapertussis. Les patients qui en sont atteints peuvent manifester un large éventail de symptômes en fonction de l'âge, de l'état vaccinal et des co-infections, ce qui complique souvent le diagnostic (1,2).…”

Section: Introductionunclassified

Caractéristiques cliniques des cas pédiatriques de coqueluche au Québec, 2015 à 2017

Desjardins¹,

Iachimov²,

Mousseau³

et al. 2018

RMTC

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Contexte : L'introduction du vaccin anticoquelucheux acellulaire pourrait avoir modifié les caractéristiques épidémiologiques et cliniques de la coqueluche chez les enfants canadiens. Objectif : Décrire les données démographiques, les manifestations clinique et les issues cliniques chez les enfants et les adolescents atteints de coqueluche s'étant présentés dans un hôpital de soins tertiaires. Méthodologie : Étude de cohorte rétrospective menée chez des patients consécutifs examinés au Centre hospitalier universitaire Sainte-Justine (CHUSJ) et soumis à une recherche par amplification en chaîne par polymérase (polymerase chain reaction [PCR]) multiplex en temps réel pour les bactéries Bordetella pertussis ou B. parapertussis entre juin 2015 et mars 2017. Les données démographiques, les manifestations cliniques et les issues ont été décrites pour les résultats positifs. L'échelle modifiée de Preziosi a servi à évaluer la gravité de la maladie; une forme grave de la maladie correspond à un score de sept et plus. Résultats : La distribution par âge des 144 patients dont les résultats de PCR étaient positifs et qui ont été reçus en consultation au CHUSJ s'établissait comme suit : moins de trois mois (n = 25/144, 17,4 %), de quatre mois à neuf ans (n = 63/144, 43,8 %) et de dix à 18 ans (n = 56/144, 38,9 %). Les symptômes les plus courants comprenaient la toux paroxystique (70,1 %), la toux émétisante (47,2 %) et la rhinorrhée (33,3 %). Chez les nourrissons de moins de trois mois, plus de 84,0 % des cas consistaient en une coqueluche grave (92,0 % ont nécessité une hospitalisation et 28,0 % ont été admis aux soins intensifs). Chez les enfants de quatre mois à neuf ans, 22,2 % étaient atteints d'une coqueluche grave et 11,1 % ont été hospitalisés. Seulement deux (3,6 %) enfants de plus de dix ans présentaient une forme grave de la maladie. Conclusion : La coqueluche touche encore des enfants de tous âges au Québec. Chez les enfants plus âgés, la maladie est plus souvent bénigne. Chez les nourrissons qui ne bénéficient pas encore de la protection complète offerte par la vaccination, la maladie est souvent grave, en particulier chez ceux de moins de trois mois. Ces données probantes viennent appuyer la mise en oeuvre d'un programme de vaccination contre la coqueluche chez les femmes enceintes.

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Pertussis

Cited by 49 publications

References 101 publications

Recurrent Cough Syncope Due to Pertussis in Adults: Report of Three Cases and Review of the Literature

Recurrent Cough Syncope Due to Pertussis in Adults: Report of Three Cases and Review of the Literature

Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

Caractéristiques cliniques des cas pédiatriques de coqueluche au Québec, 2015 à 2017

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