Development of Inositol Trisphosphate-Induced Calcium Release Mechanism during Maturation of Hamster Oocytes

Fujiwara, Toshihiro; Nakada, Ken; Shirakawa, Hideki; Miyazaki, Shunichi

doi:10.1006/dbio.1993.1059

Cited by 158 publications

(109 citation statements)

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“…This was expected by data on myoIns uptake in mouse preimplantation embryos and its incorporation into phosphatidylinositides (PtdIns) [22]. A higher availability of PtdIns may increase the production of intracellular second messengers and upregulate a number of cellular functions including proliferation [3,15,38,43]. Since myoIns has been reported to increase PKB/Akt phosphorylation in mouse skeletal muscle cells [8], among signal transduction mechanisms possibly induced as a consequence of myoIns medium supplementation and by increased PtdIns availability, is the phosphorylation of this enzyme [27], the activation and nuclear mobilitation of which promotes proliferation activity of mouse embryo blastomeres [14].…”

Section: Discussionmentioning

confidence: 92%

Improvement of mouse embryo quality by myo-inositol supplementation of IVF media

Colazingari

Fiorenza

Carlomagno³

et al. 2014

J Assist Reprod Genet

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Objective Myo-inositol (myoIns) has a positive role in mammalian development and human reproduction. Since experiments on farming species suggest a similar role in preimplantation development, we evaluated the hypothesis that the inclusion of myoIns in human embryo culture media would produce an increase in embryo quality in IVF cycles, using the mouse embryo assay. Methods To determine the effect of myoIns on completion of preimplantation development in vitro, one-cell embryos of the inbred C57BL/6N mouse strain were produced by ICSI, cultured in human fertilization media in the presence of myoIns (myoIns+) or in its absence (myoIns-) and evaluated morphologically. Daily progression through cleavage stages, blastocyst production and expansion and blastomere number at 96 hours post fertilization were assessed. Results Compared to myoIns-embryos, myoIns+ embryos displayed a faster cleavage rate and by the end of preimplantation development, the majority of myoIns+ blastocysts was expanded and formed by a higher number of blastomeres. Conclusion The presence of myoIns resulted in both an increase in proliferation activity and developmental rate of in vitro cultured early mouse embryos, representing a substantial improvement of culture conditions. These data may identify myoIns as an important supplement for human embryo preimplantation culture.

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Section: Discussionmentioning

confidence: 92%

Improvement of mouse embryo quality by myo-inositol supplementation of IVF media

Colazingari

Fiorenza

Carlomagno³

et al. 2014

J Assist Reprod Genet

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“…2). The first Ca 2þ transient in mammals is larger and more sustained then the ensuing Ca 2þ spikes, and occurs as a Ca 2þ wave as is the case in Xenopus (Fujiwara et al, 1993;Shiraishi et al, 1995;Carroll et al, 1996). Some Ca 2þ oscillations are apparent during the plateau phase in mouse, but are absent in Xenopus (Fig.…”

Section: Spatial and Temporal Dynamics Of Ca 2r Signals During Maturamentioning

confidence: 86%

“…An increase in the sensitivity of IP 3 -dependent Ca 2þ release during oocyte maturation is a hallmark of Ca 2þ signaling differentiation in many species, including starfish (Chiba et al, 1990), hamster (Fujiwara et al, 1993), mouse (Jones et al, 1994;Mehlmann and Kline, 1994), and Xenopus (Terasaki et al, 2001;Machaca, 2004). However, the mechanisms underlying this enhanced Ca 2þ release are vaguely defined in the literature.…”

Section: Physiological Roles Of Ca 2r At Fertilizationmentioning

confidence: 99%

Ca²⁺ signaling differentiation during oocyte maturation

Machaca

2007

Journal Cellular Physiology

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Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca 2þ signaling pathways endowing the egg with the capacity to produce a specialized Ca 2þ transient at fertilization that is necessary and sufficient for egg activation. Consequently, mechanistic elucidation of Ca 2þ signaling differentiation during oocyte maturation is fundamental to our understanding of egg activation, and offers a glimpse into Ca 2þ signaling regulation during the cell cycle.

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“…Nevertheless, some processes of cytoplasmic maturation are coordinated with, and in some cases might actually depend upon, the initial events of nuclear maturation. For example, the sensitivity of the intracellular calcium release system to inositol trisphosphate (IPS) is acquired gradually during the progression of nuclear maturation (Fujiwara et al, 1993). Similarly, the ability of the oocyte to undergo localized sperm-induced release of cortical granules is acquired before metaphase I, but the propagation of a normal wave of cortical granule release can only occur when sperm entry takes place between the first and second metaphase (Ducibella and Buetow, 1994).…”

Section: Coordination Of Nuclear and Cytoplasmic Maturationmentioning

confidence: 99%

Mammalian oocyte growth and development in vitro

1996

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This paper is a review of the current status of technology for mammalian oocyte growth and development in vitro. It compares and contrasts the characteristics of the various culture systems that have been devised for the culture of either isolated preantral follicles or the oocyte-granulosa cell complexes from preantral follicles. The advantages and disadvantages of these various systems are discussed. Endpoints for the evaluation of oocyte development in vitro, including oocyte maturation and embryogenesis, are described. Considerations for the improvement of the culture systems are also presented. These include discussions of the possible effects of apoptosis and inappropriate differentiation of oocyte-associated granulosa cells on oocyte development. Finally, the potential applications of the technology for oocyte growth and development in vitro are discussed. For example, studies of oocyte development in vitro could help to identify specific molecules produced during oocyte development that are essential for normal early embryogenesis and perhaps recognize defects leading to infertility or abnormalities in embryonic development. Moreover, the culture systems may provide the methods necessary to enlarge the populations of valuable agricultural, pharmaceutical product-producing, and endangered animals, and to rescue the oocytes of women about to undergo clinical procedures that place oocytes at risk. o 1996 WiIey-Liss, Inc.

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Development of Inositol Trisphosphate-Induced Calcium Release Mechanism during Maturation of Hamster Oocytes

Cited by 158 publications

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Improvement of mouse embryo quality by myo-inositol supplementation of IVF media

Improvement of mouse embryo quality by myo-inositol supplementation of IVF media

Ca²⁺ signaling differentiation during oocyte maturation

Mammalian oocyte growth and development in vitro

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Development of Inositol Trisphosphate-Induced Calcium Release Mechanism during Maturation of Hamster Oocytes

Cited by 158 publications

References 0 publications

Improvement of mouse embryo quality by myo-inositol supplementation of IVF media

Improvement of mouse embryo quality by myo-inositol supplementation of IVF media

Ca2+ signaling differentiation during oocyte maturation

Mammalian oocyte growth and development in vitro

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Ca²⁺ signaling differentiation during oocyte maturation