Development of Inspired Therapeutics Pediatric VAD: Benchtop Evaluation of Impeller Performance and Torques for MagLev Motor Design

Tompkins, Landon H; Prina, Steven R; Gellman, Barry; Morello, Gino; Roussel, Thomas J.; Kopechek, Jonathan A.; Williams, Stuart J.; Petit, Priscilla C; Slaughter, Mark S.; Koenig, Steven C.; Dasse, Kurt A.

doi:10.1007/s13239-021-00578-z

Cited by 2 publications

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“…The impeller/rotor’s motor is a slot-less brushless DC design and operates over the rotational speed range of 500 RPM to 6000 RPM. After calculating and empirically confirming the torque requirements of the pump to achieve the required flows and pressures [ 14 ], a full-custom motor and linear VCA were designed. The system’s power supply is a commercial-off-the-shelf (COTS) design with a universal AC input and 24 VDC output, which provided the current required for longitudinal position control during lift-off and for operating the motor over the required speed range.…”

Section: Methodsmentioning

confidence: 99%

Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

et al. 2022

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Inspired Therapeutics (Merritt Island, FL) is developing a mechanical circulatory support (MCS) system designed as a single driver with interchangeable, extracorporeal, magnetically levitated pumps. The NeoMate system design features an integrated centrifugal rotary pump, motor, and controller that will be housed in a single compact unit. Conceptually, the primary innovation of this technology will be the combination of disposable, low-cost pumps for use with a single, multi-functional, universal controller to support multiple pediatric cardiopulmonary indications. In response to the paucity of clinically available pediatric devices, Inspired Therapeutics is specifically targeting the underserved neonate and infant heart failure (HF) patient population first. In this article, we present the development of the prototype Inspired Therapeutics NeoMate System for pediatric left ventricular assist device (LVAD) support, and feasibility testing in static mock flow loops (H-Q curves), dynamic mock flow loops (hemodynamics), and in an acute healthy ovine model (hemodynamics and clinical applicability). The resultant hydrodynamic and hemodynamic data demonstrated the ability of this prototype pediatric LVAD and universal controller to function over a range of rotary pump speeds (500–6000 RPM), to provide pump flow rates of up to 2.6 L/min, and to volume unload the left ventricle in acute animals. Key engineering challenges observed and proposed solutions for the next design iteration are also presented.

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Section: Methodsmentioning

confidence: 99%

Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

et al. 2022

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Effect of Blade Thickness on Hemodynamics and Hemolysis: A Case Study of Pediatric Centrifugal Blood Pumps

Abbasnezhad,

Bakir

2024

Journal of Biomechanical Engineering

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Blood pumps have become popular whether for use as an implantable ventricular assist device or as extracorporeal membrane oxygenation. The quality of these pumps is assessed according to their ability to reduce the risk of blood damage thanks to an optimal choice of their geometric and operating properties. Lack of the research focused on the geometrical optimization of impellers has prompted this study. This study evaluated a computational and experimental analysis comparing the hemolytic performance of three centrifugal pumps. For this purpose, methods of Eulerian and Lagrangian are respectively used for hemodynamic and hemocompatibility investigations. Referring to the pediatric demands, these pumps function under clinically applicable pressure-flow conditions: 1 l/min of blood flow and a pressure differential of 60 mm Hg. These three pumps all use the same volute, but their impellers differ in terms of blade thickness. The objective is to examine how surface area affects the generation of hemolysis. In silico simulations were employed for both of the following tasks: first, identifying the distributions of velocities, pressures, and shear stresses; second, applying the Lagrangian approach to estimate the hemolysis index. Results showed the importance of the flow passage and the surface of the clearance on the hemocompatibility of the pumps. However, it was observed that there is not a linear effect of the blade thickness on the shear stress or index of hemolysis. Additionally, this work can provide information to develop an optimal design of a more hemocompatible blood pump.

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Development of Inspired Therapeutics Pediatric VAD: Benchtop Evaluation of Impeller Performance and Torques for MagLev Motor Design

Cited by 2 publications

References 20 publications

Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

Effect of Blade Thickness on Hemodynamics and Hemolysis: A Case Study of Pediatric Centrifugal Blood Pumps

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