Development of inter-polymeric complex of anionic polysaccharides, alginate/k-carrageenan bio-platform for burn dressing

Zia, Tahmina; Usman, Muhammad; Sabir, Aneela; Shafiq, Muhammad; Khan, Rafi Ullah

doi:10.1016/j.ijbiomac.2020.04.157

Cited by 30 publications

(6 citation statements)

References 53 publications

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“…The liquid mixture of AgNPs and SA contained solid deposits, which was attributed to the crosslinking of SA and AgNPs. 30,31 Therefore, to obtain stable colloidal solutions, AgNPs were coated with SF. The colloidal solution stably mixed with the SA solution.…”

Section: Discussionmentioning

confidence: 99%

Biocompatible sodium alginate–silk fibroin antibacterial microspheres from a microfluidic platform for infected wound repair

Liu,

Zhou,

Yang

et al. 2024

Journal of Bioactive and Compatible Polymers

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Micro/nano drug delivery systems can provide ideal controlled drug release. Microfluidic chip technology plays an important role in the preparation of microspheres. Sodium alginate (SA) has been used to prepare microspheres as drug carriers owing to its good biosafety and easy preparation. However, these microspheres lack antimicrobial activity and drug loading efficiency, which prevent their application for infected wound repair. Although silver nanoparticles (AgNPs) possess broad-spectrum antibiotic activity, liquid mixtures of AgNPs and SA are too unstable to fabricate drug-loaded microspheres using microfluidic chip technology. In this study, AgNPs were coated with silk fibroin (SF) and then dispersed in SA solution to fabricate antibacterial microspheres (denoted SA-SF-Ag) using microfluidic chip technology. SA-SF-Ag effectively inhibited the growth of microorganisms and gradually released AgNPs. Moreover, in vivo results showed that SA-SF-Ag promoted infected wound healing and angiogenesis by killing Pseudomonas aeruginosa on the surface of infected skin wounds of mouse models. This study offers a new method to integrate AgNPs into organic polymeric microspheres for the treatment of infected wounds.

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Section: Discussionmentioning

confidence: 99%

Biocompatible sodium alginate–silk fibroin antibacterial microspheres from a microfluidic platform for infected wound repair

Liu,

Zhou,

Yang

et al. 2024

Journal of Bioactive and Compatible Polymers

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“…Enrichment of the ALG formulations with CAR most frequently resulted in swelling increases [ 236 , 237 ], although a decrease was also demonstrated [ 240 ]. Reduction of the absorption capacity with the addition of CAR was noted [ 237 ], however, an improvement in the healing process was reported [ 238 ]. CAR was also considered in the use in encapsulating probiotic bacteria and bacteriophages [ 239 , 240 ] to increase the stability and protection of microorganisms.…”

Section: Discussionmentioning

confidence: 99%

“…The addition of CAR increased the pore size of the dressing. On the other hand, Zia T. et al [ 238 ] observed an improvement in tensile strength and Young’s modulus with increasing κ-CAR content in ALG–CAR dressings enriched by silver with antibacterial properties. In addition, an improvement in wound healing was observed with an increase in CAR content in the formulation after the dressing was applied to the rat wound; thus, increasing the concentration of CAR might lead to faster wound healing.…”

Section: Utilization Of Alg Mixed With Selected Naturally Derived Pol...mentioning

confidence: 99%

Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms

Kruk

Winnicka

2022

Marine Drugs

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Alginates (ALG) have been used in biomedical and pharmaceutical technologies for decades. ALG are natural polymers occurring in brown algae and feature multiple advantages, including biocompatibility, low toxicity and mucoadhesiveness. Moreover, ALG demonstrate biological activities per se, including anti-hyperlipidemic, antimicrobial, anti-reflux, immunomodulatory or anti-inflammatory activities. ALG are characterized by gelling ability, one of the most frequently utilized properties in the drug form design. ALG have numerous applications in pharmaceutical technology that include micro- and nanoparticles, tablets, mucoadhesive dosage forms, wound dressings and films. However, there are some shortcomings, which impede the development of modified-release dosage forms or formulations with adequate mechanical strength based on pure ALG. Other natural polymers combined with ALG create great potential as drug carriers, improving limitations of ALG matrices. Therefore, in this paper, ALG blends with pectins, chitosan, gelatin, and carrageenans were critically reviewed.

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“…Penggunaan dalam formulasi obat dapat dimanfaatkan untuk mengenkapsulasi bahan aktif yang bertujuan untuk memproteksi dari degradasi (60) , mengontrol pelepasan zat aktif, meningkatkan absorpsi air selama swelling (20) , meningkatkan sifat mekanik mikrobeads (61) , memproteksi dari cairan lambung, serta meningkatkan efisiensi enkapsulasi (62) . Kombinasi alginat dengan karagenan telah banyak digunakan dalam formulasi mengenkapsulasi bahan aktif yang bertujuan untuk meningkatkan efektivitas zat aktif (47,63) , meningkatkan kekuatan mekanik (19,64) , memiliki kapasitas adsorpsi yang baik (64) , mengontrol lipid digesti (65) , mengontrol pelepasan zat aktif (6,(66)(67)(68)(69)(70)(71)(72)(73) , meningkatkan stabilitas (74)(75)(76) , meningkatkan stabilitas tekstur (77) , meningkatkan efesiensi enkapsulasi (74,78) , meningkatkan kekuatan mekanik dan biologis (79,80) , serta sebagai pembawa obat tertarget (73) .…”

Section: Pemanfaatan Kombinasi Polimerunclassified

Review Sinergisitas Kombinasi Polimer Alami Serta Pemanfaatan dalam Formulasi Obat

et al. 2021

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Pengetahuan tentang sinergisme bermanfaat untuk menentukan kombinasi polimer alami yang memberikan efek menguntungkan ketika dikombinasikan. Interaksi yang saling menguntungkan antar polimer alami dapat dilihat dari nilai sinergisitas dari data pengujian viskositas. Kombinasi polimer yang memiliki efek sinergi dapat memberikan banyak kegunaan serta manfaat yang besar dalam pengembangan teknologi formulasi obat sehingga dapat mengatasi kekurangan yang dimiliki oleh masing-masing zat aktif obat. Pada studi ini, dilakukan review artikel tentang sinergisme kombinasi polimer, pengaruh kation sebagai cross-linker, serta aplikasi kombinasi alginat dengan polimer alami dalam formulasi sediaan obat dan aspek farmakologinya. Database yang digunakan untuk mengambil referensi, meliputi Scopus, PubMed, dan Google Schoolar. Tipe data dari database meliputi jurnal, artikel review, maupun buku tanpa ada pembatasan tahun. Referensi yang diperoleh dari database lalu diidentifikasi, dianalisis, dan dipilih yang sesuai dengan topik yang akan direview. Formulasi dengan polimer menghasilkan obat dengan pelepasan terkontrol, yang memiliki keuntungan, yakni dapat menurunkan frekuensi pemberian dosis, menurunkan efek samping obat, meningkatkan tingkat kepatuhan pasien, menurunkan fluktuasi, serta memperlama durasi aksi obat, dan memastikan respon farmakokinetik dan farmakodinamik dapat reprodusibel dan diprediksi. Selain itu, polimer dapat pula dimodifikasi sedemikian rupa untuk menjadi sistem penghantaran obat tertarget pada organ tertentu. Polimer alami yang paling banyak digunakan dan dikombinasikan dengan polimer lain adalah alginat karena memiliki struktur dengan banyak gugus negatif berupa karboksil dan hidroksil sehingga memiliki berbagai keuntungan, seperti dapat meningkatkan kelarutan obat, meningkatkan kemampuan mukoadesif, melepaskan obat secara terkontrol, serta menghantarkan obat pada target organ tertentu.

show abstract

Development of inter-polymeric complex of anionic polysaccharides, alginate/k-carrageenan bio-platform for burn dressing

Cited by 30 publications

References 53 publications

Biocompatible sodium alginate–silk fibroin antibacterial microspheres from a microfluidic platform for infected wound repair

Biocompatible sodium alginate–silk fibroin antibacterial microspheres from a microfluidic platform for infected wound repair

Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms

Review Sinergisitas Kombinasi Polimer Alami Serta Pemanfaatan dalam Formulasi Obat

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