Development of localized cul-de-sac endometrioid carcinoma associated with deep infiltrating endometriosis during remission of early endometrial cancer

Seki, Katsura; Ishikawa, Hiroshi; Hashimoto, Rei; Mitsuhashi, Akira; Ikeda, Jun‐ichiro; Shozu, Makio

doi:10.1016/j.gore.2019.100526

Cited by 3 publications

(3 citation statements)

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“…Ferrari et al 14 reported a case of clear cell carcinoma in a parietal endometriosis lesion (post‐cesarean section and transverse laparotomy), while Chen et al 15 reported two cases of high‐grade serous cancer (HGSC) in an endometriosis of the utero‐sacral ligament, followed by Johnson et al 16 and Song et al, 17 each of whom reported a case of HGSC from in a rectal endometriosis. If we add the cases of cervical and rectal degeneration associated with Lynch syndrome, 18 and vaginal degeneration associated with endometrial cancer, 19 , 20 there are less than 10 cases of degeneration described in the literature (Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

An exceptional case of degenerative endometriosis of the uterine torus

Merviel

Rebahi

James

et al. 2023

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

An exceptional case of degenerative endometriosis of the uterine torus

Merviel

Rebahi

James

et al. 2023

Clinical Case Reports

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“…Most malignant tumors arising from endometriosis are derived from the ovarian endometrioma. However, malignant tumors arising from superficial peritoneal endometriosis lesions or DIEs are rare and standard therapy has not yet been established [ 6 – 9 ]. Hence, endometriosis can be malignant not only in the ovarian endometrioma but also in extra-gonadal endometriosis; nevertheless, there have been few reports of malignant tumors occurring as metachronous tumors in these endometriosis lesions [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Primary endometrioid carcinoma of the uterosacral ligament arising from deep infiltrating endometriosis 6 years after bilateral salpingo-oophorectomy due to atypical proliferative endometrioid tumor of the ovary: a rare case report

Ota

Takahashi

et al. 2020

World J Surg Onc

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Background Endometriosis can potentially lead to the development of a malignant tumor. Most malignant tumors arising from the endometriosis originate from the ovarian endometrioma, whereas those arising from extragonadal lesions are rare. We report a rare case of endometrioid carcinoma that developed from deep infiltrating endometriosis in the uterosacral ligament 6 years after treatment for atypical proliferative endometrioid tumor of the ovary in a 48-year-old woman. Case presentation Six years ago, the patient underwent laparoscopic bilateral salpingo-oophorectomy for her right ovarian tumor with atypical proliferative (borderline) endometrioid tumor accompanied by ovarian endometrioma. The solid tumor in the cul-de-sac was detected during follow-up using magnetic resonance imaging. Positron emission tomography/computed tomography revealed an abnormal accumulation of 18F-fluorodeoxyglucose at the tumor site. Thus, tumor recurrence with borderline malignancy was suspected. The patient underwent diagnostic laparoscopy followed by hysterectomy and partial omentectomy. Retroperitoneal pelvic lymphadenectomy and para-aortic lymphadenectomy were also performed. The cul-de-sac tumor at the left uterosacral ligament was microscopically diagnosed as invasive endometrioid carcinoma arising from deep infiltrating endometriosis. The final diagnosis was primary stage IIB peritoneal carcinoma. The patient received six courses of monthly paclitaxel and carboplatin as adjuvant chemotherapy. The patient showed no evidence of recurrence for 2 years after the treatments. Conclusion This study reports a rare case of metachronous endometriosis-related malignancy that developed 6 years after treatment for borderline ovarian tumor. If endometriosis lesions remain after bilateral salpingo-oophorectomy, the physician should keep the malignant nature of endometriosis in mind.

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“…Most malignant tumors arising from endometriosis are derived from the ovarian endometrioma. However, malignant tumors arising from super cial peritoneal endometriosis lesions or DIEs are rare and standard therapy has not yet been established [6][7][8][9]. Hence, endometriosis can be malignant not only in the ovarian endometrioma but also in extra-gonadal endometriosis; nevertheless, there have been few reports of malignant tumors occurring as metachronous tumors in these endometriosis lesions [10].…”

Section: Introductionmentioning

confidence: 99%

Primary endometrioid carcinoma of the uterosacral ligament arising from deep infiltrating endometriosis after 6 years bilateral salpingo-oophorectomy due to atypical proliferative endometrioid tumor of the ovary: a rare case report

Ota

Ota²,

Takahashi³

et al. 2020

Preprint

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Background: Endometriosis can potentially lead to the development of a malignant tumor. Most malignant tumors arising from the endometriosis originate from the ovarian endometrioma, whereas those arising from extragonadal lesions are rare. We report a rare case of endometrioid carcinoma that developed from deep infiltrating endometriosis in the uterosacral ligament 6 years after treatment for atypical proliferative endometrioid tumor of the ovary in a 48-year-old woman.Case presentation: Six years ago, the patient underwent laparoscopic bilateral salpingo-oophorectomy for her right ovarian tumor with atypical proliferative (borderline) endometrioid tumor accompanied by ovarian endometrioma. The solid tumor in the cul-de-sac was detected during follow-up using magnetic resonance imaging. Positron emission tomography/computed tomography revealed an abnormal accumulation of 18F-fluorodeoxyglucose at the tumor site. Thus, tumor recurrence with borderline malignancy was suspected. The patient underwent diagnostic laparoscopy followed by hysterectomy and partial omentectomy. Retroperitoneal pelvic lymphadenectomy and para-aortic lymphadenectomy were also performed. The cul-de-sac tumor at the left uterosacral ligament was microscopically diagnosed as invasive endometrioid carcinoma arising from deep infiltrating endometriosis. The final diagnosis was primary stage IIB peritoneal carcinoma. The patient received six courses of monthly paclitaxel and carboplatin as adjuvant chemotherapy. The patient showed no evidence of recurrence for 2 years after the treatments.Conclusion: This study reports a rare case of metachronous endometriosis-related malignancy that developed 6 years after treatment for borderline ovarian tumor. If endometriosis lesions remain after bilateral salpingo-oophorectomy, the physician should keep the malignant nature of endometriosis in mind.

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Development of localized cul-de-sac endometrioid carcinoma associated with deep infiltrating endometriosis during remission of early endometrial cancer

Cited by 3 publications

References 11 publications

An exceptional case of degenerative endometriosis of the uterine torus

An exceptional case of degenerative endometriosis of the uterine torus

Primary endometrioid carcinoma of the uterosacral ligament arising from deep infiltrating endometriosis 6 years after bilateral salpingo-oophorectomy due to atypical proliferative endometrioid tumor of the ovary: a rare case report

Primary endometrioid carcinoma of the uterosacral ligament arising from deep infiltrating endometriosis after 6 years bilateral salpingo-oophorectomy due to atypical proliferative endometrioid tumor of the ovary: a rare case report

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