DEVELOPMENT OF LONG-LASTING ANTIMICROBIAL AND POTENTIAL HEMOSTATIC NANOCOMPOSITES (pyrophyllite based) WITH PVP-coated COLLOIDAL SILVER NANOPARTICLES

Abstract

Pyrophyllite clay, modified with PVP coated silver nanoparticles (PYRO-PVP/AgNPs), with recently proved antibacterial activity was prepared. Silver nanoparticles were synthesized by the chemical reduction method of AgNO3 using NaBH4 and poly(vinyl pyrrolidone) (PVP) as a stabilizer and excellent dispersant. This research aimed to elucidate the mechanisms and kinetics of AgNPs, along with the PVP protective mechanism responsible for antibacterial activity towards the microorganisms. Pioneering steps were made toward coagulation studies due to the potential of aluminosilicate layered clays to serve as alternatives to hemostatic agents currently in use. The isoelectric point of pyrophyllite samples with 5, 20, and 45 μm diameter particles and PYRO/PVP/AgNPs sample (Ag25mg/L) was evaluated to understand how the anticoagulant or procoagulant properties of the pyrophyllite varied according to the pH of the isoelectric point. Characterization of the PYRO-PVP/AgNPs samples was performed using FTIR spectroscopy, while the release mechanism and kinetics of silver ions were monitored using atomic absorption spectroscopy (AAS). Additionally, AAS was used for the evaluation of heavy metals content in pyrophyllite clay and a simple, cost-effective procedure was proposed for the extraction of heavy metals.

Influence of Thermal Water Types on the Properties of Pyrophilite Peloids

“…Pyrophyllite and other aluminosilicates have wide applications in medicine due to their antiseptic, antitoxic and antibacterial properties [8]. Physical-chemical properties of pyrophylliteshale from the "Parsovići" deposit fulfil many of the requirements for use in pelotherapy [9,10]. The aim of this study was to analyze the main mineralogical related changes during the maturation process of pyrophyllite in four different mineral waters from Bosnia and Herzegovina and to determine the physicochemical properties of maturated peloids.…”